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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

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                                SCHEDULE 13E-4

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                         ISSUER TENDER OFFER STATEMENT
                     (Pursuant to Section 13(e)(1) of the
                       Securities Exchange Act of 1934)
                               (AMENDMENT NO. 1)

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                             ELI LILLY AND COMPANY
                               (Name of Issuer)

                             ELI LILLY AND COMPANY
                     (Name of Person(s) Filing Statement)

                             COMMON STOCK, WITHOUT
                                   PAR VALUE
                        (Title of Class of Securities)

                                  532457 10 8
                     (CUSIP Number of Class of Securities)

                                REBECCA O. GOSS
                             ELI LILLY AND COMPANY
                            LILLY CORPORATE CENTER
                          INDIANAPOLIS, INDIANA 46285
                                (317) 276-2000

                                   -Copy to-

                                BERNARD E. KURY
                               DEWEY BALLANTINE
                          1301 AVENUE OF THE AMERICAS
                         NEW YORK, NEW YORK 10019-6092
                                (212) 259-8000

          (Name, Address and Telephone Number of Person Authorized to
                Receive Notices and Communications on Behalf of
                          Person(s) Filing Statement)

                                AUGUST 21, 1995
                   (Date Tender Offer First Published, Sent
                         or Given to Security Holders)

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          This statement amends Item 9 of the Rule 13e-4 Issuer Tender Offer 
Statement on Schedule 13E-4, filed with the Securities and Exchange Commission 
on August 21, 1995 (File No. 005-17885) ("Schedule 13E-4") relating to an offer 
by Eli Lilly and Company (the "Company") to exchange (the "Exchange Offer") 
57,600,000 shares of Common Stock, without par value, of Guidant Corporation 
(the "Guidant Common Stock") which the Company owns for shares of the Company's 
Common Stock, without par value, upon the terms and subject to the conditions 
stated in the Offering Circular - Prospectus dated August 21, 1995 (the 
"Offering Circular - Prospectus") attached to the Schedule 13E-4 as Exhibit 
(a)(2) and the related Letter of Transmittal attached to the Schedule 13E-4 as 
Exhibit (a)(4).

ITEM 9.   MATERIAL TO BE FILED AS EXHIBITS.

          (a)(11)  Letter to Shareholders dated September 6, 1995.

          (a)(12)  Press Release dated September 6, 1995.



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                                   SIGNATURE

        After due inquiry and to the best of my knowledge and belief, I certify 
that the information set forth in this statement is true, complete and correct.


Dated: September 6, 1995


                                           ELI LILLY AND COMPANY
         
         
         
                                           By  /s/  EDWIN W. MILLER
                                             -------------------------
                                             Name:  EDWIN W. MILLER
                                             Title: VICE PRESIDENT AND TREASURER



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                                 EXHIBIT INDEX


Exhibit No.             Description                     Page No.
- -----------             -----------                     --------

(a)(11)                 Letter to Shareholders
                        dated September 6, 1995

(a)(12)                 Press Release dated
                        September 6, 1995




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                                                                 EXHIBIT (a)(11)

                       [LOGO OF ELI LILLY AND COMPANY]
 
                             ELI LILLY AND COMPANY
                            LILLY CORPORATE CENTER
                          INDIANAPOLIS, INDIANA 46285
 
                                                              September 6, 1995
 
Dear Shareholder:
 
  By now you should have received a packet of documents relating to the
Exchange Offer commenced on August 21, 1995 by Eli Lilly and Company ("Lilly")
to its shareholders to exchange 3.49 shares of the common stock of Guidant
Corporation ("Guidant") owned by Lilly for each share of common stock of Lilly
up to an aggregate of 16,504,298 shares of Lilly common stock. Included in the
packet is an Offering Circular-Prospectus that describes the Exchange Offer
and the business of Guidant and Lilly.
 
  The purpose of this letter is to update certain portions of the Offering
Circular-Prospectus that describe Guidant's business.
 
  First, under the heading "New Products" on page 67, the third paragraph is
supplemented as follows:
 
    In August 1995, Guidant began human implants of the ACS MULTI-
  LINK (TM)coronary stent as part of its U.S. clinical trials. Stents are
  metal tubes or coils that are mounted on a dilatation catheter, which is
  inflated to expand the stent in the artery. When the catheter is removed
  from the artery, the stent stays in place, which provides a "mechanical"
  way of keeping the artery open. The ACS MULTI-LINK Stent is designed for
  optimal radial strength, and features multiple linked rings for flexibility
  and conformity. It is an expandable stent that is 15mm long, and has been
  mounted on a delivery system that incorporates a selection of low-profile,
  low-compliant PE-600 (R) balloons. The delivery system utilizes distinct
  markers to position and deploy the stent. Between the ACS MULTI-LINK Stent
  and the catheter is a specially designed elastomeric membrane, which
  distributes the dilatation force evenly--ensuring complete concentric
  expansion of the stent, and producing a streamlined profile on retraction.
  A flexible, retractable sleeve covers the entire catheter, including the
  stent. This protects both the stent and the artery while the stent is being
  maneuvered through the coronary artery.
 
  Second, under the heading "Implantable Tachy Products," beginning on page
69, the second to last paragraph (pp. 70-71) is supplemented as follows:
 
    The first human implants of the VENTAK (R) MINI (TM) family of AICD (TM)
  Automatic Cardioverter Defibrillator devices occurred in August 1995. The
  VENTAK MINI includes Guidant's biphasic waveform, 6 minutes of diagnostic-
  quality stored electrograms, and comprehensive therapy and diagnostics,
  making it the world's smallest full-featured implantable defibrillator. The
  VENTAK MINI pulse generator is 68 cc in size and weighs 125 grams, making
  it 30 percent smaller than the VENTAK PRx III, Guidant's most recently
  market-released predecessor.
 
  Third, under the heading "Patents, Trademarks, Proprietary Rights and
Licenses," beginning on page 79, the fourth paragraph is supplemented as
follows:
 
    On August 28, 1995, Guidant received a letter from Pacesetter, Inc.
  advising Guidant that Pacesetter believes that certain Pacesetter patents
  are being used by Guidant in connection with Guidant's VIGOR
  pacemaker/programmer combination. The letter requests that Guidant cease
  using

 
  such patents. The Pacesetter letter also advises that it appears to
  Pacesetter that Guidant may also be using two patents licensed to
  Pacesetter in connection with Guidant's VENTAK MINI. Pacesetter has
  suggested in its letter that it believes it is in the parties' mutual
  interest to enter into a cross license agreement.
 
    Guidant is currently evaluating the patents presented by Pacesetter,
  particularly in the light of Guidant's own portfolio of patents and patent
  applications covering implantable defibrillators, pacemakers, leads and
  programmers (including the Mirowski basic tachycardia patent portfolio). To
  date, Guidant's evaluation of Pacesetter's patents and the two patents
  licensed to Pacesetter has not established any improper use of these
  patents. Litigation by Pacesetter seeking injunctive and monetary relief is
  a possibility. However, Guidant believes that any outcome of this matter
  will not have a material adverse effect on Guidant.
 
  The Exchange Offer expires at midnight, New York City time, on Monday,
September 18, 1995. If you have any questions about the Exchange Offer or would
like additional copies of any of the Exchange Offer documents, please call the
Information Agent, D.F. King & Co., Inc., at one of the following numbers:
 
            United States           (800) 207-3158
            Europe                  (44) 171-600-5005 (collect)
            Outside U.S. and Europe (212) 269-5550 (collect)
 
                                          Sincerely,
 
                                          /s/ Randall L. Tobias

                                          Randall L. Tobias
                                          Chairman and Chief Executive Officer
 
This is a supplement to the Offering Circular-Prospectus dated August 21, 1995.
 
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                                                                 EXHIBIT (a)(12)

      SUPPLEMENT TO OFFERING CIRCULAR-PROSPECTUS FILED FOR LILLY/GUIDANT
                                EXCHANGE OFFER

Eli Lilly and Company and Guidant Corporation today announced that they have 
filed a supplement to the Offering Circular-Prospectus of August 21, 1995 in 
connection with the exchange offer of 3.49 shares of common stock of Guidant 
for each share of Lilly.  The supplement, a copy of which is attached to this 
release, updates certain portions of the description of Guidant's business to 
reflect developments since August 21.  The supplement will be mailed to all 
Lilly shareholders this week.

The exchange offer expires at midnight, New York City time, on Monday, September
18, 1995.  Questions regarding the exchange offer may be addressed to the 
Information Agent, D.F. King & Co., Inc., at the phone numbers listed on the 
attachment.

Lilly is a global research-based pharmaceutical corporation headquartered in 
Indianapolis, Ind., that is dedicated to creating and delivering superior health
care solutions--by combining pharmaceutical innovation, existing pharmaceutical 
technology, disease prevention and management and information technologies--in 
order to provide customers worldwide with optimal clinical and economic 
outcomes.

A leader in the medical device industry, Guidant Corporation provides 
innovative, cost-effective products and services to the global cardiology and
minimally invasive surgery marketplaces. Guidant comprises Advanced
Cardiovascular Systems, Inc. (ACS), Cardiac Pacemakers, Inc. (CPI), Devices for
Vascular Intervention, Inc. (DVI), Heart Rhythm Technologies Incorporated (HRT),
Origin Medsystems, Inc. and the company's international affiliates.