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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-A

               For Registration of Certain Classes of Securities
                   Pursuant to Section 12(b) or 12(g) of the
                        Securities Exchange Act of 1934





                             ELI LILLY AND COMPANY
       ----------------------------------------------------------------
             (Exact name of registrant as specified in its charter)


          Indiana                                           35-0470950
  ------------------------                           -------------------------
  (State of incorporation                                 (I.R.S. Employer
         or organization)                                Identification No.)

  Lilly Corporate Center
   Indianapolis, Indiana                                        46285
  ------------------------                           -------------------------
  (Address of principal                                       (Zip Code)
    executive offices)




Securities to be registered pursuant to Section 12(b) of the
Act:


Title of each class                              Name of each exchange on
to be so registered                              which each class is to be
                                                 listed



6.57% Notes Due 2016                             New York Stock Exchange, Inc.
- ------------------------------                   -----------------------------

6.77% Notes Due 2036                             New York Stock Exchange, Inc.
- ------------------------------                   -----------------------------

Securities to be registered pursuant to Section 12(g) of the
Act:  None.

If this Form relates to the registration of a class of debt
securities and is effective upon filing pursuant to General
Instruction A.(c)(1), please check the following box. [X]













Item 1.           Description of Registrant's Securities to be Registered.

                  The description of the Registrant's 6.57% Notes Due
                  January 1, 2016 and the Registrant's 6.77% Notes Due
                  January 1, 2036 to be registered hereby is contained
                  on pages S-4 and S-5 of the Prospectus Supplement
                  dated January 5, 1996 and pages 3 through 11,
                  inclusive, of the Prospectus dated June 1, 1995, which
                  are filed with the Commission under Rule 424 as a
                  supplement to the Registrant's registration statement
                  on Form S-3 (File No. 33-58977), and such description
                  is incorporated herein by this reference.


Item 2.           Exhibits.

  1.1             Certificates evidencing Registrant's 6.57% Notes Due
                  January 1, 2016.

  1.2             Certificates evidencing Registrant's 6.77% Notes Due
                  January 1, 2036.

  2.1             Indenture dated as of February 1, 1991 between the
                  Registrant and Citibank, N.A., Trustee, with respect
                  to the 6.57% Notes Due January 1, 2016 and the 6.77%
                  Notes Due January 1, 2036 was filed with the
                  Commission as Exhibit 4.1 to registration statement on
                  Form S-3 (File No. 33-58977) and is incorporated
                  herein by this reference.






                                       2










                                   SIGNATURE

         Pursuant to the requirements of Section 12 of the
Securities Exchange Act of 1934, the Registrant has duly caused
this Registration Statement to be signed on its behalf by the
undersigned, thereto duly authorized, on January 10, 1996.


                                            ELI LILLY AND COMPANY


                                            By: /s/ Sidney Taurel
                                                ---------------------------
                                                Sidney Taurel
                                                Executive Vice President
                                                and Acting Chief Financial
                                                Officer








                                       3





                                 EXHIBIT INDEX

Exhibit Number Description of Exhibit - ------- ---------------------- 1.1 Certificates evidencing Registrant's 6.57% Notes Due January 1, 2016. 1.2 Certificates evidencing Registrant's 6.77% Notes Due January 1, 2036. 2.1 Indenture dated as of February 1, 1991 between the Registrant and Citibank, N.A., Trustee, with respect to the 6.57% Notes Due January 1, 2016 and the 6.77% Notes Due January 1, 2036 was filed with the Commission as Exhibit 4.1 to registration statement on Form S-3 (File No. 33-58977) and is incorporated herein by this reference.
4



                                                             CUSIP NO. 532457AN8

                  UNLESS THIS GLOBAL NOTE IS PRESENTED BY
                  AN AUTHORIZED REPRESENTATIVE OF THE
                  DEPOSITORY TRUST COMPANY ("DTC") TO THE
                  COMPANY OR ITS AGENT FOR REGISTRATION OF
                  TRANSFER, EXCHANGE OR PAYMENT, AND ANY
                  NOTE ISSUED IS REGISTERED IN THE NAME OF
                  CEDE & CO. OR SUCH OTHER NAME AS
                  REQUESTED BY AN AUTHORIZED
                  REPRESENTATIVE OF DTC AND ANY PAYMENT IS
                  MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
                  OR OTHER USE HEREOF FOR VALUE OR
                  OTHERWISE BY OR TO ANY PERSON IS
                  WRONGFUL SINCE THE REGISTERED OWNER
                  HEREOF, CEDE & CO., HAS AN INTEREST
                  HEREIN.

                  UNLESS AND UNTIL IT IS EXCHANGED IN
                  WHOLE OR IN PART FOR NOTES IN DEFINITIVE
                  FORM, THIS GLOBAL NOTE MAY NOT BE
                  TRANSFERRED EXCEPT AS A WHOLE BY DTC TO
                  A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
                  TO DTC OR ANOTHER NOMINEE OF DTC, OR BY
                  DTC OR ANY SUCH NOMINEE TO A SUCCESSOR
                  DEPOSITARY OR A NOMINEE OF SUCH
                  SUCCESSOR DEPOSITARY.


                                           ELI LILLY AND COMPANY

                                            6.57% Note Due 2016


REGISTERED NO. R-1                                               $200,000,000.00


                  ELI LILLY AND COMPANY, an Indiana corporation
(herein called the "Company"), for value received, hereby
promises to pay to CEDE & CO. or registered assigns, the
principal sum of TWO HUNDRED MILLION DOLLARS
($200,000,000.00) on January 1, 2016, upon surrender of this
Global Note at the office or agency of the Company for such
payment in The City of New York, in such coin or currency of
the United States of America as at the time of payment shall
be legal tender for the payment of public and private debts,
and to pay interest on said principal sum until maturity at
the rate of 6.57% per annum, at such office or agency, in
like coin or currency, semi-annually on January 1 and July 1
of each year, commencing July 1, 1996, until the date on
which payment of said principal sum has been made or duly












provided for; provided, however, that at the option of the
Company, payment of interest may be made by check mailed to
the address of the person entitled thereto as such address
shall appear in the Note Register.  Such interest shall be
payable from the January 1 or the July 1, as the case may
be, next preceding the date hereof to which interest has
been paid, unless the date hereof is a January 1 or July 1
to which interest has been paid, in which case from the date
hereof, or unless the date hereof is prior to the payment of
any interest on the Notes, in which case from January 1,
1996; provided, however, that if the Company shall default
in payment of the interest due on such January 1 or July 1,
then from the preceding January 1 or July 1 to which
interest has been paid or, if no interest has been paid on
the Notes, from January 1, 1996.  The interest payable
hereon on any interest payment date shall be payable to the
person in whose name this Note is registered at the close of
business on the fifteenth day of the calendar month
preceding the month in which such interest payment is due,
except as otherwise provided in the Indenture hereinafter
referred to.

                  The provisions of this Note are continued on the
reverse hereof and such continued provisions shall for all
purposes have the same effect as though fully set forth at
this place.

                  This Note shall not be valid or become obligatory
for any purpose until the certificate of authentication
hereon shall have been signed by the Trustee under the
Indenture.





                      [THIS SPACE INTENTIONALLY LEFT BLANK]





                                                   2









                  IN WITNESS WHEREOF, ELI LILLY AND COMPANY has
caused this Instrument to be signed manually or by facsimile
signature of its President or one of its Vice Presidents and
by its Secretary or one of its Assistant Secretaries, and a
facsimile of its corporate seal to be affixed hereto or
imprinted hereon.


Dated:  January 10, 1996.

                                                     ELI LILLY AND COMPANY


                                                     By: /s/ Edwin W. Miller
                                                         ---------------------
                                                         Edwin W. Miller
                                                         Vice President and
                                                         Treasurer


                                                 By: /s/ Daniel P. Carmichael
                                                         ---------------------
                                                         Daniel P. Carmichael
                                                         Secretary






                                                   3









                  This is one of the Notes of the series designated
herein issued under the Indenture described herein.


                                                     CITIBANK, N.A.,
                                                        as Trustee


                                                     By: /s/ Robert Kirchner
                                                         ---------------------
                                                           Authorized Officer





                             FORM OF REVERSE OF NOTE

                  This Note is one of a duly authorized issue of a
series of debt securities (the "Securities") of the Company,
designated as its 6.57% Notes Due 2016 (the "Notes").  The
Notes are limited to $200,000,000 aggregate principal amount
and the Securities, including the Notes, are all issued or
to be issued under and pursuant to the Indenture dated as of
February 1, 1991 (herein called the "Indenture"), duly
executed and delivered by the Company to Citibank, N.A., as
Trustee (herein called the "Trustee"), to which Indenture
and all Board Resolutions (as defined in the Indenture) as
provided therein, reference is hereby made for a description
of the rights, limitation of rights, obligations, duties and
immunities thereunder of the Trustee, the Company and
holders of the Notes.

                  In case an Event of Default, as defined in the
Indenture, shall have occurred and be continuing with
respect to the Notes, the principal hereof may be declared,
and upon such declaration shall become, due and payable, in
the manner, with the effect and subject to the conditions
provided in the Indenture.  The Indenture provides that the
holders of the majority in aggregate principal amount of the
Notes at the time outstanding may on behalf of the holders
of all of the Notes waive any past default under the
Indenture and its consequences, except a default in the
payment of the principal of or interest on any of the Notes,
in the manner and to the extent provided in the Indenture.

                  The Indenture contains provisions permitting the
Company and the Trustee, with consent of the holders of not
less than a majority of the aggregate principal amount of the Notes
at the time outstanding, evidenced as in the Indenture
provided, to execute supplemental indentures adding any
provisions to or changing in any manner or eliminating any
of the provisions of the Indenture or of any supplemental





                                                   4








indenture with respect to the Notes, or modifying in any
manner the rights of the holders of the Notes; provided,
however, that no supplemental indenture shall (i) extend the
maturity of any Note, or reduce the principal amount
thereof, or reduce the rate or extend the time of payment of
interest thereon, or make the principal thereof or interest
thereon payable in any coin or currency other than as provided in
the Notes, without the consent of the holder of
each Note so affected, or (ii) reduce the aforesaid
percentage of Notes, the holders of which are required to
consent to any such supplemental indenture, without the
consent of the holders of all Notes then outstanding.

                  The Notes do not have a sinking fund.

                  The Notes will be redeemable as a whole or in
part, at the option of the Company at any time, at a
Redemption Price equal to the greater of (i) 100% of their
principal amount or (ii) the sum of the present values of
the remaining scheduled payments of principal and interest
thereon discounted to the date of redemption (the
"Redemption Date") on a semiannual basis (assuming a 360-
day-year consisting of twelve 30-day months) at the Treasury
Yield, plus in each case accrued interest to the Redemption
Date.

                  "Treasury Yield" means, with respect to any
Redemption Date, the rate per annum equal to the semiannual
equivalent yield to maturity of the Comparable Treasury
Issue, assuming a price for the Comparable Treasury Issue
(expressed as a percentage of its principal amount) equal to
the Comparable Treasury Price for such Redemption Date.

                  "Comparable Treasury Issue" means the United
States Treasury security selected by an Independent
Investment Banker as having a maturity comparable to the
remaining term of the Notes that would be utilized, at the
time of selection and in accordance with customary financial
practice, in pricing new issues of corporate debt securities
of comparable maturity to the remaining term of the Notes.
"Independent Investment Banker" means Morgan Stanley & Co.
Incorporated or, if such firm is unwilling or unable to
select the Comparable Treasury Issue, an independent
investment banking institution of national standing
appointed by the Trustee.

                  "Comparable Treasury Price" means, with respect to
any Redemption Date, (i) the average of the bid and asked
prices for the Comparable Treasury Issue (expressed in each
case as a percentage of its principal amount) on the third
business day preceding such Redemption Date, as set forth in
the daily statistical release (or any successor release)
published by the Federal Reserve Bank of New York and





                                                   5








designated "Composite 3:30 p.m. Quotations for U.S.
Government Securities" or (ii) if such release (or any
successor release) is not published or does not contain such
prices on such business day, the average of the Reference
Treasury Dealer Quotations for such Redemption Date.
"Reference Treasury Dealer Quotations" means, with respect
to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Trustee, of the bid and
asked prices for the Comparable Treasury Issue (expressed in
each case as a percentage of its principal amount) quoted in
writing to the Trustee by such Reference Treasury Dealer at
5:00 p.m. on the third business day preceding such
Redemption Date.

                  "Reference Treasury Dealer" means each of Morgan
Stanley & Co. Incorporated, Goldman, Sachs & Co. and J.P.
Morgan Securities Inc. and their respective successors;
provided however, that if any of the foregoing shall cease
to be a primary U.S. Government securities dealer in New
York City (a "Primary Treasury Dealer"), the Company shall
substitute therefor another Primary Treasury Dealer.

                  Holders of Notes to be redeemed will receive
notice thereof by first-class mail at least 30 and not more
than 60 days prior to the date fixed for redemption.

                  No reference herein to the Indenture and no
provision of this Note or of the Indenture or of any Board
Resolution shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the
principal of and interest on this Note at the time and place
and at the rate and in the coin or currency herein
prescribed.

                  This Note is transferable by the registered holder
hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency
to be maintained by the Company for that purpose in The City
of New York, but only in the manner, subject to the
limitations and upon payment of any tax or governmental
charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and
cancellation of this Note.  Upon any registration of
transfer, a new registered Note or Notes, of authorized
denomination or denominations, and in the same aggregate
principal amount, will be issued to the transferee in
exchange therefor.

                  The Company, the Trustee, any paying agent and any
Note registrar may deem and treat the registered holder
hereof as the absolute owner of this Note (whether or not
this Note shall be overdue and notwithstanding any notations
of ownership or other writing hereon made by anyone other





                                                   6








than the Note registrar) for the purpose of receiving
payment of or on account of the principal hereof and
interest due hereon as herein provided and for all other
purposes, and neither the Company nor the Trustee nor any
paying agent nor any Note registrar shall be affected by any
notice to the contrary.

                  No recourse shall be had for the payment of the
principal of or interest on this Note, or for any claim
based hereon, or otherwise in respect hereof, or based on or
in respect of the Indenture or any indenture supplemental
thereto or any Board Resolution, against an incorporator,
stockholder, officer or director, as such, past, present or
future, of the Company or of any successor corporation,
whether by virtue of any constitution, statute or rule of
law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance
hereof and as part of the consideration for the issue
hereof, expressly waived and released.








                                                   7








                                                             CUSIP NO. 532457AP3
                                                             -------------------


                  UNLESS THIS GLOBAL NOTE IS PRESENTED BY
                  AN AUTHORIZED REPRESENTATIVE OF THE
                  DEPOSITORY TRUST COMPANY ("DTC") TO THE
                  COMPANY OR ITS AGENT FOR REGISTRATION OF
                  TRANSFER, EXCHANGE OR PAYMENT, AND ANY
                  NOTE ISSUED IS REGISTERED IN THE NAME OF
                  CEDE & CO. OR SUCH OTHER NAME AS
                  REQUESTED BY AN AUTHORIZED
                  REPRESENTATIVE OF DTC AND ANY PAYMENT IS
                  MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
                  OR OTHER USE HEREOF FOR VALUE OR
                  OTHERWISE BY OR TO ANY PERSON IS
                  WRONGFUL SINCE THE REGISTERED OWNER
                  HEREOF, CEDE & CO., HAS AN INTEREST
                  HEREIN.

                  UNLESS AND UNTIL IT IS EXCHANGED IN
                  WHOLE OR IN PART FOR NOTES IN DEFINITIVE
                  FORM, THIS GLOBAL NOTE MAY NOT BE
                  TRANSFERRED EXCEPT AS A WHOLE BY DTC TO
                  A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
                  TO DTC OR ANOTHER NOMINEE OF DTC, OR BY
                  DTC OR ANY SUCH NOMINEE TO A SUCCESSOR
                  DEPOSITARY OR A NOMINEE OF SUCH
                  SUCCESSOR DEPOSITARY.


                              ELI LILLY AND COMPANY

                               6.77% Note Due 2036


  REGISTERED NO. R-1                                            $200,000,000.00


                  ELI LILLY AND COMPANY, an Indiana corporation
(herein called the "Company"), for value received, hereby
promises to pay to CEDE & CO. or registered assigns, the
principal sum of TWO HUNDRED MILLION DOLLARS
($200,000,000.00) on January 1, 2036, upon surrender of this
Global Note at the office or agency of the Company for such
payment in The City of New York, in such coin or currency of
the United States of America as at the time of payment shall
be legal tender for the payment of public and private debts,
and to pay interest on said principal sum until maturity at
the rate of 6.77% per annum, at such office or agency, in
like coin or currency, semi-annually on January 1 and July 1
of each year, commencing July 1, 1996, until the date on
which payment of said principal sum has been made or duly












provided for; provided, however, that at the option of the
Company, payment of interest may be made by check mailed to
the address of the person entitled thereto as such address
shall appear in the Note Register.  Such interest shall be
payable from the January 1 or the July 1, as the case may
be, next preceding the date hereof to which interest has
been paid, unless the date hereof is a January 1 or July 1
to which interest has been paid, in which case from the date
hereof, or unless the date hereof is prior to the payment of
any interest on the Notes, in which case from January 1,
1996; provided, however, that if the Company shall default
in payment of the interest due on such January 1 or July 1,
then from the preceding January 1 or July 1 to which
interest has been paid or, if no interest has been paid on
the Notes, from January 1, 1996.  The interest payable
hereon on any interest payment date shall be payable to the
person in whose name this Note is registered at the close of
business on the fifteenth day of the calendar month
preceding the month in which such interest payment is due,
except as otherwise provided in the Indenture hereinafter
referred to.

                  The provisions of this Note are continued on the
reverse hereof and such continued provisions shall for all
purposes have the same effect as though fully set forth at
this place.

                  This Note shall not be valid or become obligatory
for any purpose until the certificate of authentication
hereon shall have been signed by the Trustee under the
Indenture.





                      [THIS SPACE INTENTIONALLY LEFT BLANK]





                                        2









                  IN WITNESS WHEREOF, ELI LILLY AND COMPANY has
caused this Instrument to be signed manually or by facsimile
signature of its President or one of its Vice Presidents and
by its Secretary or one of its Assistant Secretaries, and a
facsimile of its corporate seal to be affixed hereto or
imprinted hereon.


Dated:  January 10, 1996.

                                                     ELI LILLY AND COMPANY

                                                 By: /s/ Edwin W. Miller
                                                     ----------------------
                                                     Edwin W. Miller
                                                     ----------------------
                                                     Vice President and
                                                     Treasurer


                                                 By: /s/ Daniel P. Carmichael
                                                     ----------------------
                                                     Daniel P. Carmichael
                                                     Secretary






                                        3









                  This is one of the Notes of the series designated
herein issued under the Indenture described herein.


                                                 CITIBANK, N.A.,
                                                    as Trustee


                                                 By: /s/ Robert Kirchner
                                                     ------------------------
                                                     Authorized Officer





                             FORM OF REVERSE OF NOTE

                  This Note is one of a duly authorized issue of a
series of debt securities (the "Securities") of the Company,
designated as its 6.77% Notes Due 2036 (the "Notes").  The
Notes are limited to $300,000,000 aggregate principal amount
and the Securities, including the Notes, are all issued or
to be issued under and pursuant to the Indenture dated as of
February 1, 1991 (herein called the "Indenture"), duly
executed and delivered by the Company to Citibank, N.A., as
Trustee (herein called the "Trustee"), to which Indenture
and all Board Resolutions (as defined in the Indenture) as
provided therein, reference is hereby made for a description
of the rights, limitation of rights, obligations, duties and
immunities thereunder of the Trustee, the Company and
holders of the Notes.

                  In case an Event of Default, as defined in the
Indenture, shall have occurred and be continuing with
respect to the Notes, the principal hereof may be declared,
and upon such declaration shall become, due and payable, in
the manner, with the effect and subject to the conditions
provided in the Indenture.  The Indenture provides that the
holders of the majority in aggregate principal amount of the
Notes at the time outstanding may on behalf of the holders
of all of the Notes waive any past default under the
Indenture and its consequences, except a default in the
payment of the principal of or interest on any of the Notes,
in the manner and to the extent provided in the Indenture.

                  The Indenture contains provisions permitting the
Company and the Trustee, with consent of the holders of not
less than a majority of the aggregate principal amount of the Notes
at the time outstanding, evidenced as in the Indenture
provided, to execute supplemental indentures adding any
provisions to or changing in any manner or eliminating any
of the provisions of the Indenture or of any supplemental





                                        4








indenture with respect to the Notes, or modifying in any
manner the rights of the holders of the Notes; provided,
however, that no supplemental indenture shall (i) extend the
maturity of any Note, or reduce the principal amount
thereof, or reduce the rate or extend the time of payment of
interest thereon, or make the principal thereof or interest
thereon payable in any coin or currency other than as provided in
the Notes, without the consent of the holder of
each Note so affected, or (ii) reduce the aforesaid
percentage of Notes, the holders of which are required to
consent to any such supplemental indenture, without the
consent of the holders of all Notes then outstanding.

                  The Notes do not have a sinking fund.

                  The Notes will be redeemable as a whole or in
part, at the option of the Company at any time, at a
Redemption Price equal to the greater of (i) 100% of their
principal amount or (ii) the sum of the present values of
the remaining scheduled payments of principal and interest
thereon discounted to the date of redemption (the
"Redemption Date") on a semiannual basis (assuming a 360-
day-year consisting of twelve 30-day months) at the Treasury
Yield, plus in each case accrued interest to the Redemption
Date.

                  "Treasury Yield" means, with respect to any
Redemption Date, the rate per annum equal to the semiannual
equivalent yield to maturity of the Comparable Treasury
Issue, assuming a price for the Comparable Treasury Issue
(expressed as a percentage of its principal amount) equal to
the Comparable Treasury Price for such Redemption Date.

                  "Comparable Treasury Issue" means the United
States Treasury security selected by an Independent
Investment Banker as having a maturity comparable to the
remaining term of the Notes, which prior to 2007 will be
deemed to be a 30-year Treasury security, that would be
utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of
corporate debt securities of comparable maturity to the
remaining term of the Notes.  "Independent Investment
Banker" means Morgan Stanley & Co. Incorporated or, if such
firm is unwilling or unable to select the Comparable
Treasury Issue, an independent investment banking
institution of national standing appointed by the Trustee.

                  "Comparable Treasury Price" means, with respect to
any Redemption Date, (i) the average of the bid and asked
prices for the Comparable Treasury Issue (expressed in each
case as a percentage of its principal amount) on the third
business day preceding such Redemption Date, as set forth in
the daily statistical release (or any successor release)





                                        5








published by the Federal Reserve Bank of New York and
designated "Composite 3:30 p.m. Quotations for U.S.
Government Securities" or (ii) if such release (or any
successor release) is not published or does not contain such
prices on such business day the average of the Reference
Treasury Dealer Quotations for such Redemption Date.
"Reference Treasury Dealer Quotations" means, with respect
to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Trustee, of the bid and
asked prices for the Comparable Treasury Issue (expressed in
each case as a percentage of its principal amount) quoted in
writing to the Trustee by such Reference Treasury Dealer at
5:00 p.m. on the third business day preceding such
Redemption Date.

                  "Reference Treasury Dealer" means each of Morgan
Stanley & Co. Incorporated, Goldman, Sachs & Co. and J.P.
Morgan Securities Inc. and their respective successors;
provided however, that if any of the foregoing shall cease
to be a primary U.S. Government securities dealer in New
York City (a "Primary Treasury Dealer"), the Company shall
substitute therefor another Primary Treasury Dealer.

                  Holders of Notes to be redeemed will receive
notice thereof by first-class mail at least 30 and not more
than 60 days prior to the date fixed for redemption.

                  No reference herein to the Indenture and no
provision of this Note or of the Indenture or of any Board
Resolution shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the
principal of and interest on this Note at the time and place
and at the rate and in the coin or currency herein
prescribed.

                  This Note is transferable by the registered holder
hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency
to be maintained by the Company for that purpose in The City
of New York, but only in the manner, subject to the
limitations and upon payment of any tax or governmental
charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and
cancellation of this Note.  Upon any registration of
transfer, a new registered Note or Notes, of authorized
denomination or denominations, and in the same aggregate
principal amount, will be issued to the transferee in
exchange therefor.

                  The Company, the Trustee, any paying agent and any
Note registrar may deem and treat the registered holder
hereof as the absolute owner of this Note (whether or not
this Note shall be overdue and notwithstanding any notations





                                        6








of ownership or other writing hereon made by anyone other
than the Note registrar) for the purpose of receiving
payment of or on account of the principal hereof and
interest due hereon as herein provided and for all other
purposes, and neither the Company nor the Trustee nor any
paying agent nor any Note registrar shall be affected by any
notice to the contrary.

                  No recourse shall be had for the payment of the
principal of or interest on this Note, or for any claim
based hereon, or otherwise in respect hereof, or based on or
in respect of the Indenture or any indenture supplemental
thereto or any Board Resolution, against an incorporator,
stockholder, officer or director, as such, past, present or
future, of the Company or of any successor corporation,
whether by virtue of any constitution, statute or rule of
law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance
hereof and as part of the consideration for the issue
hereof, expressly waived and released.


                                        7










                                                             CUSIP NO. 532457AP3

                  UNLESS THIS GLOBAL NOTE IS PRESENTED BY
                  AN AUTHORIZED REPRESENTATIVE OF THE
                  DEPOSITORY TRUST COMPANY ("DTC") TO THE
                  COMPANY OR ITS AGENT FOR REGISTRATION OF
                  TRANSFER, EXCHANGE OR PAYMENT, AND ANY
                  NOTE ISSUED IS REGISTERED IN THE NAME OF
                  CEDE & CO. OR SUCH OTHER NAME AS
                  REQUESTED BY AN AUTHORIZED
                  REPRESENTATIVE OF DTC AND ANY PAYMENT IS
                  MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
                  OR OTHER USE HEREOF FOR VALUE OR
                  OTHERWISE BY OR TO ANY PERSON IS
                  WRONGFUL SINCE THE REGISTERED OWNER
                  HEREOF, CEDE & CO., HAS AN INTEREST
                  HEREIN.

                  UNLESS AND UNTIL IT IS EXCHANGED IN
                  WHOLE OR IN PART FOR NOTES IN DEFINITIVE
                  FORM, THIS GLOBAL NOTE MAY NOT BE
                  TRANSFERRED EXCEPT AS A WHOLE BY DTC TO
                  A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
                  TO DTC OR ANOTHER NOMINEE OF DTC, OR BY
                  DTC OR ANY SUCH NOMINEE TO A SUCCESSOR
                  DEPOSITARY OR A NOMINEE OF SUCH
                  SUCCESSOR DEPOSITARY.


                                 ELI LILLY AND COMPANY

                                  6.77% Note Due 2036




REGISTERED NO. R-2                                    $100,000,000.00


                  ELI LILLY AND COMPANY, an Indiana corporation
(herein called the "Company"), for value received, hereby
promises to pay to CEDE & CO. or registered assigns, the
principal sum of ONE HUNDRED MILLION DOLLARS
($100,000,000.00) on January 1, 2036, upon surrender of this
Global Note at the office or agency of the Company for such
payment in The City of New York, in such coin or currency of
the United States of America as at the time of payment shall
be legal tender for the payment of public and private debts,
and to pay interest on said principal sum until maturity at
the rate of 6.77% per annum, at such office or agency, in
like coin or currency, semi-annually on January 1 and July 1
of each year, commencing July 1, 1996, until the date on
which payment of said principal sum has been made or duly












provided for; provided, however, that at the option of the
Company, payment of interest may be made by check mailed to
the address of the person entitled thereto as such address
shall appear in the Note Register.  Such interest shall be
payable from the January 1 or the July 1, as the case may
be, next preceding the date hereof to which interest has
been paid, unless the date hereof is a January 1 or July 1
to which interest has been paid, in which case from the date
hereof, or unless the date hereof is prior to the payment of
any interest on the Notes, in which case from January 1,
1996; provided, however, that if the Company shall default
in payment of the interest due on such January 1 or July 1,
then from the preceding January 1 or July 1 to which
interest has been paid or, if no interest has been paid on
the Notes, from January 1, 1996.  The interest payable
hereon on any interest payment date shall be payable to the
person in whose name this Note is registered at the close of
business on the fifteenth day of the calendar month
preceding the month in which such interest payment is due,
except as otherwise provided in the Indenture hereinafter
referred to.

                  The provisions of this Note are continued on the
reverse hereof and such continued provisions shall for all
purposes have the same effect as though fully set forth at
this place.

                  This Note shall not be valid or become obligatory
for any purpose until the certificate of authentication
hereon shall have been signed by the Trustee under the
Indenture.





                     [THIS SPACE INTENTIONALLY LEFT BLANK]





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                  IN WITNESS WHEREOF, ELI LILLY AND COMPANY has
caused this Instrument to be signed manually or by facsimile
signature of its President or one of its Vice Presidents and
by its Secretary or one of its Assistant Secretaries, and a
facsimile of its corporate seal to be affixed hereto or
imprinted hereon.


Dated:  January 10, 1996.

                                              ELI LILLY AND COMPANY


                                              By: /s/ Edwin W. Miller
                                                  ---------------------------
                                                  Edwin W. Miller
                                                  Vice President and
                                                  Treasurer


                                              By: /s/ Daniel P. Carmichael
                                                  ---------------------------
                                                  Daniel P. Carmichael
                                                  Secretary






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                  This is one of the Notes of the series designated
herein issued under the Indenture described herein.


                                              CITIBANK, N.A.,
                                                 as Trustee


                                              By: /s/ Robert Kirchner
                                                  ---------------------------
                                                  Authorized Officer





                            FORM OF REVERSE OF NOTE

                  This Note is one of a duly authorized issue of a
series of debt securities (the "Securities") of the Company,
designated as its 6.77% Notes Due 2036 (the "Notes").  The
Notes are limited to $300,000,000 aggregate principal amount
and the Securities, including the Notes, are all issued or
to be issued under and pursuant to the Indenture dated as of
February 1, 1991 (herein called the "Indenture"), duly
executed and delivered by the Company to Citibank, N.A., as
Trustee (herein called the "Trustee"), to which Indenture
and all Board Resolutions (as defined in the Indenture) as
provided therein, reference is hereby made for a description
of the rights, limitation of rights, obligations, duties and
immunities thereunder of the Trustee, the Company and
holders of the Notes.

                  In case an Event of Default, as defined in the
Indenture, shall have occurred and be continuing with
respect to the Notes, the principal hereof may be declared,
and upon such declaration shall become, due and payable, in
the manner, with the effect and subject to the conditions
provided in the Indenture.  The Indenture provides that the
holders of the majority in aggregate principal amount of the
Notes at the time outstanding may on behalf of the holders
of all of the Notes waive any past default under the
Indenture and its consequences, except a default in the
payment of the principal of or interest on any of the Notes,
in the manner and to the extent provided in the Indenture.

                  The Indenture contains provisions permitting the
Company and the Trustee, with consent of the holders of not
less than a majority of the aggregate principal amount of the Notes
at the time outstanding, evidenced as in the Indenture
provided, to execute supplemental indentures adding any
provisions to or changing in any manner or eliminating any
of the provisions of the Indenture or of any supplemental





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indenture with respect to the Notes, or modifying in any
manner the rights of the holders of the Notes; provided,
however, that no supplemental indenture shall (i) extend the
maturity of any Note, or reduce the principal amount
thereof, or reduce the rate or extend the time of payment of
interest thereon, or make the principal thereof or interest
thereon payable in any coin or currency other than as provided in
the Notes, without the consent of the holder of
each Note so affected, or (ii) reduce the aforesaid
percentage of Notes, the holders of which are required to
consent to any such supplemental indenture, without the
consent of the holders of all Notes then outstanding.

                  The Notes do not have a sinking fund.

                  The Notes will be redeemable as a whole or in
part, at the option of the Company at any time, at a
Redemption Price equal to the greater of (i) 100% of their
principal amount or (ii) the sum of the present values of
the remaining scheduled payments of principal and interest
thereon discounted to the date of redemption (the
"Redemption Date") on a semiannual basis (assuming a 360-
day-year consisting of twelve 30-day months) at the Treasury
Yield, plus in each case accrued interest to the Redemption
Date.

                  "Treasury Yield" means, with respect to any
Redemption Date, the rate per annum equal to the semiannual
equivalent yield to maturity of the Comparable Treasury
Issue, assuming a price for the Comparable Treasury Issue
(expressed as a percentage of its principal amount) equal to
the Comparable Treasury Price for such Redemption Date.

                  "Comparable Treasury Issue" means the United
States Treasury security selected by an Independent
Investment Banker as having a maturity comparable to the
remaining term of the Notes, which prior to 2007 will be
deemed to be a 30-year Treasury security, that would be
utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of
corporate debt securities of comparable maturity to the
remaining term of the Notes.  "Independent Investment
Banker" means Morgan Stanley & Co. Incorporated or, if such
firm is unwilling or unable to select the Comparable
Treasury Issue, an independent investment banking
institution of national standing appointed by the Trustee.

                  "Comparable Treasury Price" means, with respect to
any Redemption Date, (i) the average of the bid and asked
prices for the Comparable Treasury Issue (expressed in each
case as a percentage of its principal amount) on the third
business day preceding such Redemption Date, as set forth in
the daily statistical release (or any successor release)





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published by the Federal Reserve Bank of New York and
designated "Composite 3:30 p.m. Quotations for U.S.
Government Securities" or (ii) if such release (or any
successor release) is not published or does not contain such
prices on such business day, the average of the Reference
Treasury Dealer Quotations for such Redemption Date.
"Reference Treasury Dealer Quotations" means, with respect
to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Trustee, of the bid and
asked prices for the Comparable Treasury Issue (expressed in
each case as a percentage of its principal amount) quoted in
writing to the Trustee by such Reference Treasury Dealer at
5:00 p.m. on the third business day preceding such
Redemption Date.

                  "Reference Treasury Dealer" means each of Morgan
Stanley & Co. Incorporated, Goldman, Sachs & Co. and J.P.
Morgan Securities Inc. and their respective successors;
provided however, that if any of the foregoing shall cease
to be a primary U.S. Government securities dealer in New
York City (a "Primary Treasury Dealer"), the Company shall
substitute therefor another Primary Treasury Dealer.

                  Holders of Notes to be redeemed will receive
notice thereof by first-class mail at least 30 and not more
than 60 days prior to the date fixed for redemption.

                  No reference herein to the Indenture and no
provision of this Note or of the Indenture or of any Board
Resolution shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the
principal of and interest on this Note at the time and place
and at the rate and in the coin or currency herein
prescribed.

                  This Note is transferable by the registered holder
hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency
to be maintained by the Company for that purpose in The City
of New York, but only in the manner, subject to the
limitations and upon payment of any tax or governmental
charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and
cancellation of this Note.  Upon any registration of
transfer, a new registered Note or Notes, of authorized
denomination or denominations, and in the same aggregate
principal amount, will be issued to the transferee in
exchange therefor.

                  The Company, the Trustee, any paying agent and any
Note registrar may deem and treat the registered holder
hereof as the absolute owner of this Note (whether or not
this Note shall be overdue and notwithstanding any notations





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of ownership or other writing hereon made by anyone other
than the Note registrar) for the purpose of receiving
payment of or on account of the principal hereof and
interest due hereon as herein provided and for all other
purposes, and neither the Company nor the Trustee nor any
paying agent nor any Note registrar shall be affected by any
notice to the contrary.

                  No recourse shall be had for the payment of the
principal of or interest on this Note, or for any claim
based hereon, or otherwise in respect hereof, or based on or
in respect of the Indenture or any indenture supplemental
thereto or any Board Resolution, against an incorporator,
stockholder, officer or director, as such, past, present or
future, of the Company or of any successor corporation,
whether by virtue of any constitution, statute or rule of
law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance
hereof and as part of the consideration for the issue
hereof, expressly waived and released.





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