<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:8ed454f3-10a5-4b10-aa87-04b39809a8a7,g:6277c55c-582f-466b-8f7d-959b35d7630b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.lilly.com/role/CoverPage" xlink:type="simple" xlink:href="lly-20230930.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_6665f9ba-a955-4732-be8c-20b9bb53bc26" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentType_6665f9ba-a955-4732-be8c-20b9bb53bc26" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_a156266e-092b-4c43-a912-50ea8c01377e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentPeriodEndDate_a156266e-092b-4c43-a912-50ea8c01377e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_a35dc833-f551-4f84-9292-45ca5c8ca1e6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityFileNumber_a35dc833-f551-4f84-9292-45ca5c8ca1e6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_9d0f9139-059b-4a35-8929-5f4dfe62cbcf" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityRegistrantName_9d0f9139-059b-4a35-8929-5f4dfe62cbcf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_032e60b0-b694-43e8-8d89-36346f0da7da" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityIncorporationStateCountryCode_032e60b0-b694-43e8-8d89-36346f0da7da" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_ab47766a-fd3f-460b-b7a9-88afefe4695c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityTaxIdentificationNumber_ab47766a-fd3f-460b-b7a9-88afefe4695c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_c709fda9-5b4e-47de-9865-9ce6fab550bc" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityAddressAddressLine1_c709fda9-5b4e-47de-9865-9ce6fab550bc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_481140d9-67f9-40c9-9653-0f04d12d3148" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityAddressCityOrTown_481140d9-67f9-40c9-9653-0f04d12d3148" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_b9476990-83d0-436d-9376-dd22b14b9021" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityAddressStateOrProvince_b9476990-83d0-436d-9376-dd22b14b9021" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_53dc12a3-949b-4a07-8f09-227e292c3a72" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityAddressPostalZipCode_53dc12a3-949b-4a07-8f09-227e292c3a72" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_bb398ee4-aac6-4416-90ee-f1338174d24e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_CityAreaCode_bb398ee4-aac6-4416-90ee-f1338174d24e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_0b64cad3-e53b-4bd3-ab2f-d1491d93881c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_LocalPhoneNumber_0b64cad3-e53b-4bd3-ab2f-d1491d93881c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_0f636a55-6ce9-46ea-bb35-2a987f8c3599" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_Security12bTitle_0f636a55-6ce9-46ea-bb35-2a987f8c3599" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_a99123ec-c82d-4618-b28b-c44442732fde" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_TradingSymbol_a99123ec-c82d-4618-b28b-c44442732fde" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_16b1a5f4-25ec-49a2-9a5d-c5e57c1d89f5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_SecurityExchangeName_16b1a5f4-25ec-49a2-9a5d-c5e57c1d89f5" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_413198ce-ec97-44d0-967a-643fc7d61568" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityCurrentReportingStatus_413198ce-ec97-44d0-967a-643fc7d61568" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_78d929f3-8ee3-4e48-b0bd-6cb31f660648" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityInteractiveDataCurrent_78d929f3-8ee3-4e48-b0bd-6cb31f660648" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_012aaea9-5643-4785-a7b8-664af058d731" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityFilerCategory_012aaea9-5643-4785-a7b8-664af058d731" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_8ff67b36-edff-4ebc-a311-755a95f8013b" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntitySmallBusiness_8ff67b36-edff-4ebc-a311-755a95f8013b" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_18d96e77-4536-4107-b685-f397d89c99a1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityEmergingGrowthCompany_18d96e77-4536-4107-b685-f397d89c99a1" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_bcbd8f99-d127-40d5-8728-f776c996ac36" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityShellCompany_bcbd8f99-d127-40d5-8728-f776c996ac36" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_4226eda7-e2c0-4384-8c70-94661aa9460e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_4226eda7-e2c0-4384-8c70-94661aa9460e" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_f29dc4c1-1fec-4639-84be-e4672254bc58" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_AmendmentFlag_f29dc4c1-1fec-4639-84be-e4672254bc58" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_e7d3a15d-40da-4fad-b4a4-0dafc84fe1c4" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentFiscalYearFocus_e7d3a15d-40da-4fad-b4a4-0dafc84fe1c4" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_c6e3eeef-68b5-42da-b249-973743450c70" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentFiscalPeriodFocus_c6e3eeef-68b5-42da-b249-973743450c70" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_70609f1a-f121-46b4-8912-ec120d7bed34" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_EntityCentralIndexKey_70609f1a-f121-46b4-8912-ec120d7bed34" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_586e1c76-b972-4b01-9091-25f502edad22" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_CurrentFiscalYearEndDate_586e1c76-b972-4b01-9091-25f502edad22" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_a3c97232-0cfd-45fc-a3b8-69bb0a9cb11d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentQuarterlyReport_a3c97232-0cfd-45fc-a3b8-69bb0a9cb11d" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_27e06ea2-1c82-4027-8b36-734924a27081" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentTransitionReport_27e06ea2-1c82-4027-8b36-734924a27081" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_a4ca5a48-9381-4876-bbf6-50181902cf8c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_4a834199-ec5c-41d8-887a-fbf0348efbb0" xlink:to="loc_dei_DocumentInformationTable_a4ca5a48-9381-4876-bbf6-50181902cf8c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_93afa8cb-ed49-4cd1-81a4-64600de2aaa5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_a4ca5a48-9381-4876-bbf6-50181902cf8c" xlink:to="loc_us-gaap_StatementClassOfStockAxis_93afa8cb-ed49-4cd1-81a4-64600de2aaa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_93afa8cb-ed49-4cd1-81a4-64600de2aaa5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_93afa8cb-ed49-4cd1-81a4-64600de2aaa5" xlink:to="loc_us-gaap_ClassOfStockDomain_93afa8cb-ed49-4cd1-81a4-64600de2aaa5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_93afa8cb-ed49-4cd1-81a4-64600de2aaa5" xlink:to="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_ca7ecce4-d163-4c7f-ac3f-e362de808fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_us-gaap_CommonClassAMember_ca7ecce4-d163-4c7f-ac3f-e362de808fe3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A718NotesDueJune12025Member_1bd65d07-9e99-4cee-b07a-f1c105dc1bca" xlink:href="lly-20230930.xsd#lly_A718NotesDueJune12025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A718NotesDueJune12025Member_1bd65d07-9e99-4cee-b07a-f1c105dc1bca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1.625NotesDueJune22026Member_f231acfe-23b2-445c-8700-b7399f93d3a5" xlink:href="lly-20230930.xsd#lly_A1.625NotesDueJune22026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A1.625NotesDueJune22026Member_f231acfe-23b2-445c-8700-b7399f93d3a5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A2.125NotesDueJune32030Member_084bd34b-a9ce-403a-938d-0612ab7f925e" xlink:href="lly-20230930.xsd#lly_A2.125NotesDueJune32030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A2.125NotesDueJune32030Member_084bd34b-a9ce-403a-938d-0612ab7f925e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A625NotesDue2031Member_5df9a97d-6998-48fd-8faf-b58dbd91673f" xlink:href="lly-20230930.xsd#lly_A625NotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A625NotesDue2031Member_5df9a97d-6998-48fd-8faf-b58dbd91673f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A500NotesDue2033Member_ee635a4a-4542-4601-b838-3116af089bff" xlink:href="lly-20230930.xsd#lly_A500NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A500NotesDue2033Member_ee635a4a-4542-4601-b838-3116af089bff" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A6.77NotesDueJanuary12036Member_aed84da7-f04a-4bb4-9941-09687406230f" xlink:href="lly-20230930.xsd#lly_A6.77NotesDueJanuary12036Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A6.77NotesDueJanuary12036Member_aed84da7-f04a-4bb4-9941-09687406230f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1625NotesDue2043Member_6edf1221-df98-495c-b1d5-6b9f553829b9" xlink:href="lly-20230930.xsd#lly_A1625NotesDue2043Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A1625NotesDue2043Member_6edf1221-df98-495c-b1d5-6b9f553829b9" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1700NotesDue2049Member_254457e1-6eec-4b71-bc9d-ecec56e039c7" xlink:href="lly-20230930.xsd#lly_A1700NotesDue2049Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A1700NotesDue2049Member_254457e1-6eec-4b71-bc9d-ecec56e039c7" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1125NotesDue2051Member_021cb93a-57b5-41ea-8e74-9182808db7d4" xlink:href="lly-20230930.xsd#lly_A1125NotesDue2051Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A1125NotesDue2051Member_021cb93a-57b5-41ea-8e74-9182808db7d4" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1375NotesDue2061Member_367e0dce-ab53-4a53-a05b-58fdf8345b00" xlink:href="lly-20230930.xsd#lly_A1375NotesDue2061Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b6327c9-09f0-4799-ba7b-ffa1bad17870" xlink:to="loc_lly_A1375NotesDue2061Member_367e0dce-ab53-4a53-a05b-58fdf8345b00" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsofEquity" xlink:type="simple" xlink:href="lly-20230930.xsd#ConsolidatedCondensedStatementsofEquity"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsofEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_1590602f-346f-4089-9972-ca705500564e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1590602f-346f-4089-9972-ca705500564e" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_2fb23bf0-cef6-46fe-bbaa-e32d511deecb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_CommonStockSharesIssued_2fb23bf0-cef6-46fe-bbaa-e32d511deecb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_6e3c9733-7555-403d-84de-bfa16d948445" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_TreasuryStockCommonShares_6e3c9733-7555-403d-84de-bfa16d948445" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_fb8167e3-1646-4367-a2d7-be0ffb1eb152" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_fb8167e3-1646-4367-a2d7-be0ffb1eb152" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_58a89663-6004-4983-88da-81ca96c6ea8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_ProfitLoss_58a89663-6004-4983-88da-81ca96c6ea8f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_9307c109-ef1f-431f-abbf-5a6457a7c9bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_9307c109-ef1f-431f-abbf-5a6457a7c9bd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Dividends_ef22f3d8-9938-4642-a73c-c75e82bd2bb0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Dividends"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_Dividends_ef22f3d8-9938-4642-a73c-c75e82bd2bb0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_c8bd7f04-146d-41dc-84f5-ae799adf152b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockSharesRetired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_c8bd7f04-146d-41dc-84f5-ae799adf152b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_d9ee5c00-bf5f-474b-bec2-f0d52db06d67" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_d9ee5c00-bf5f-474b-bec2-f0d52db06d67" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_4a461fd1-53ca-4b4a-bddf-2cfd7ae3fe43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_4a461fd1-53ca-4b4a-bddf-2cfd7ae3fe43" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_e870f328-8eee-42e0-a22a-70cc9c0ed4ea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_e870f328-8eee-42e0-a22a-70cc9c0ed4ea" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_1e933548-5a8b-4fb8-a80b-aac3ae8ba038" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_1e933548-5a8b-4fb8-a80b-aac3ae8ba038" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_8d3bdfe9-71bc-4dc1-a1f6-a79520fd93d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_8d3bdfe9-71bc-4dc1-a1f6-a79520fd93d6" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_442f2d0e-779c-4bb6-81c7-5ffd693e86cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_442f2d0e-779c-4bb6-81c7-5ffd693e86cd" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_e7cad0c9-959d-4d66-a4d9-996fb230e209" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_bd4fe1ad-b5be-4139-82b1-9296f32ff709" xlink:to="loc_us-gaap_StockholdersEquityOther_e7cad0c9-959d-4d66-a4d9-996fb230e209" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_64800f2d-6dbd-4e56-a469-3a1e284c2d56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_68b4bc40-cd27-4346-9bad-63f45c7b38b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3aa6fbb7-a7d0-40e4-9680-7a74cf080578" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_980822b8-ba9c-49b6-add4-d3def44e0ed5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_1590602f-346f-4089-9972-ca705500564e" xlink:to="loc_us-gaap_StatementTable_980822b8-ba9c-49b6-add4-d3def44e0ed5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_762d8476-22fe-4a32-aa99-f5944243f338" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_980822b8-ba9c-49b6-add4-d3def44e0ed5" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_762d8476-22fe-4a32-aa99-f5944243f338" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_762d8476-22fe-4a32-aa99-f5944243f338_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_762d8476-22fe-4a32-aa99-f5944243f338" xlink:to="loc_us-gaap_EquityComponentDomain_762d8476-22fe-4a32-aa99-f5944243f338_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_762d8476-22fe-4a32-aa99-f5944243f338" xlink:to="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_38ea1a9c-0354-4214-8439-5b9dbbc73910" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_CommonStockMember_38ea1a9c-0354-4214-8439-5b9dbbc73910" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_386f3daf-6581-4d4c-a88c-1c789043ac9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_386f3daf-6581-4d4c-a88c-1c789043ac9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_f89f359f-8be1-4cb9-8d0d-6f719bd9829a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_RetainedEarningsMember_f89f359f-8be1-4cb9-8d0d-6f719bd9829a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_71f90866-4317-4cff-98e1-fff0f4651164" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TrustForBenefitOfEmployeesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_71f90866-4317-4cff-98e1-fff0f4651164" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_84841b3d-69ab-4512-b5ee-655bdfc4fa5b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_84841b3d-69ab-4512-b5ee-655bdfc4fa5b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_9d455260-e89d-4942-a494-fbade4e817bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_TreasuryStockCommonMember_9d455260-e89d-4942-a494-fbade4e817bc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_92cb98a8-dab2-4124-855b-dde00134f5a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_952a9e85-065d-4835-a4c6-ecfce0177423" xlink:to="loc_us-gaap_NoncontrollingInterestMember_92cb98a8-dab2-4124-855b-dde00134f5a9" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/BasisofPresentationDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#BasisofPresentationDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/BasisofPresentationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationLineItems_4a710a62-5989-48d4-b153-d216ab93c462" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_63352c63-57c0-4c44-9ba2-a06c7be56d62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationLineItems_4a710a62-5989-48d4-b153-d216ab93c462" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_63352c63-57c0-4c44-9ba2-a06c7be56d62" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8b9f5687-daa8-4d9c-946f-a3d95cdbd858" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationLineItems_4a710a62-5989-48d4-b153-d216ab93c462" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8b9f5687-daa8-4d9c-946f-a3d95cdbd858" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationTable_0d54f1e3-969a-4984-b24d-464f449eacc2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationLineItems_4a710a62-5989-48d4-b153-d216ab93c462" xlink:to="loc_us-gaap_ReclassificationTable_0d54f1e3-969a-4984-b24d-464f449eacc2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementAxis_91319380-4330-4282-8a87-d55395019808" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RestatementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationTable_0d54f1e3-969a-4984-b24d-464f449eacc2" xlink:to="loc_srt_RestatementAxis_91319380-4330-4282-8a87-d55395019808" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_91319380-4330-4282-8a87-d55395019808_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RestatementDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RestatementAxis_91319380-4330-4282-8a87-d55395019808" xlink:to="loc_srt_RestatementDomain_91319380-4330-4282-8a87-d55395019808_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_95adfc35-a5ad-4d23-82bd-272117533f0c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RestatementDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RestatementAxis_91319380-4330-4282-8a87-d55395019808" xlink:to="loc_srt_RestatementDomain_95adfc35-a5ad-4d23-82bd-272117533f0c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RevisionOfPriorPeriodReclassificationAdjustmentMember_8fe1391d-a407-45f6-9ee7-8ad7aa8a2f04" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RevisionOfPriorPeriodReclassificationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RestatementDomain_95adfc35-a5ad-4d23-82bd-272117533f0c" xlink:to="loc_srt_RevisionOfPriorPeriodReclassificationAdjustmentMember_8fe1391d-a407-45f6-9ee7-8ad7aa8a2f04" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueScheduleofRevenueRecognizedDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#RevenueScheduleofRevenueRecognizedDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueScheduleofRevenueRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_60babeb4-a9e4-4ac9-acd6-5690222cac62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_3449ebc1-1717-4831-8d90-e9d28dcf3ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_60babeb4-a9e4-4ac9-acd6-5690222cac62" xlink:to="loc_us-gaap_Revenues_3449ebc1-1717-4831-8d90-e9d28dcf3ffa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_ef407bc9-7be5-40c0-bbc8-16ce1461f4f6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_60babeb4-a9e4-4ac9-acd6-5690222cac62" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_ef407bc9-7be5-40c0-bbc8-16ce1461f4f6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_808ada89-2645-412a-82f3-27225dc69e0f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ef407bc9-7be5-40c0-bbc8-16ce1461f4f6" xlink:to="loc_srt_ProductOrServiceAxis_808ada89-2645-412a-82f3-27225dc69e0f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_808ada89-2645-412a-82f3-27225dc69e0f_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_808ada89-2645-412a-82f3-27225dc69e0f" xlink:to="loc_srt_ProductsAndServicesDomain_808ada89-2645-412a-82f3-27225dc69e0f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e45a807a-a09b-48e1-98c7-bd6e9443db8b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_808ada89-2645-412a-82f3-27225dc69e0f" xlink:to="loc_srt_ProductsAndServicesDomain_e45a807a-a09b-48e1-98c7-bd6e9443db8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_63508c56-2abe-4bac-a6ef-10b10980684d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_e45a807a-a09b-48e1-98c7-bd6e9443db8b" xlink:to="loc_us-gaap_ProductMember_63508c56-2abe-4bac-a6ef-10b10980684d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborationandOtherRevenueMember_0642f246-8f20-45ce-9e54-53deb6dce0c9" xlink:href="lly-20230930.xsd#lly_CollaborationandOtherRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_e45a807a-a09b-48e1-98c7-bd6e9443db8b" xlink:to="loc_lly_CollaborationandOtherRevenueMember_0642f246-8f20-45ce-9e54-53deb6dce0c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_f47a2679-96ac-47bf-a311-71c34fae1413" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_e45a807a-a09b-48e1-98c7-bd6e9443db8b" xlink:to="loc_us-gaap_RoyaltyMember_f47a2679-96ac-47bf-a311-71c34fae1413" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueAdjustmentstoRevenueDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#RevenueAdjustmentstoRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueAdjustmentstoRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateLineItems_563d95a9-d022-4423-820b-92c66f382d51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInAccountingEstimateLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_008faeca-e082-4293-a666-bde77f8e013a" xlink:href="lly-20230930.xsd#lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_563d95a9-d022-4423-820b-92c66f382d51" xlink:to="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_008faeca-e082-4293-a666-bde77f8e013a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_c45a60df-3df2-41fb-b0a4-9ead1a6fcf51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfChangeInAccountingEstimateTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_563d95a9-d022-4423-820b-92c66f382d51" xlink:to="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_c45a60df-3df2-41fb-b0a4-9ead1a6fcf51" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_4c74c7b5-e92f-479c-8a69-22de511f394e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_c45a60df-3df2-41fb-b0a4-9ead1a6fcf51" xlink:to="loc_srt_StatementGeographicalAxis_4c74c7b5-e92f-479c-8a69-22de511f394e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4c74c7b5-e92f-479c-8a69-22de511f394e_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_4c74c7b5-e92f-479c-8a69-22de511f394e" xlink:to="loc_srt_SegmentGeographicalDomain_4c74c7b5-e92f-479c-8a69-22de511f394e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_421dd18b-3d44-4324-bd27-6d14ee23e9c1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_4c74c7b5-e92f-479c-8a69-22de511f394e" xlink:to="loc_srt_SegmentGeographicalDomain_421dd18b-3d44-4324-bd27-6d14ee23e9c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_9e4a1316-821a-4662-bd8f-0448b8efa77f" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_421dd18b-3d44-4324-bd27-6d14ee23e9c1" xlink:to="loc_country_US_9e4a1316-821a-4662-bd8f-0448b8efa77f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_bf5be3c4-8848-4f1b-8265-c7a2dec498bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_c45a60df-3df2-41fb-b0a4-9ead1a6fcf51" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_bf5be3c4-8848-4f1b-8265-c7a2dec498bb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_bf5be3c4-8848-4f1b-8265-c7a2dec498bb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_bf5be3c4-8848-4f1b-8265-c7a2dec498bb" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_bf5be3c4-8848-4f1b-8265-c7a2dec498bb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_99942994-a220-4a96-8716-047f4c14d296" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_bf5be3c4-8848-4f1b-8265-c7a2dec498bb" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_99942994-a220-4a96-8716-047f4c14d296" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesReturnsAndAllowancesMember_4d1f8f9e-c9c7-47af-8804-f5d153ea2d82" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SalesReturnsAndAllowancesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_99942994-a220-4a96-8716-047f4c14d296" xlink:to="loc_us-gaap_SalesReturnsAndAllowancesMember_4d1f8f9e-c9c7-47af-8804-f5d153ea2d82" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyProductDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#RevenueDisaggregationofRevenuebyProductDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyProductDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_c0c267fa-54ce-4752-b600-56b38ef25903" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_f658923d-935a-4ad7-af34-f24518ff65d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_c0c267fa-54ce-4752-b600-56b38ef25903" xlink:to="loc_us-gaap_Revenues_f658923d-935a-4ad7-af34-f24518ff65d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_736e1972-f06d-42c7-bc97-e39e2b1bd3e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_c0c267fa-54ce-4752-b600-56b38ef25903" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_736e1972-f06d-42c7-bc97-e39e2b1bd3e8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_736e1972-f06d-42c7-bc97-e39e2b1bd3e8" xlink:to="loc_srt_ProductOrServiceAxis_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0" xlink:to="loc_srt_ProductsAndServicesDomain_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_6c782f72-25e0-42b9-b3bf-a6ec2f2846b0" xlink:to="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:href="lly-20230930.xsd#lly_DiabetesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:to="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TrulicityMember_841871c9-ac65-4c7d-81c6-160651005ba6" xlink:href="lly-20230930.xsd#lly_TrulicityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_TrulicityMember_841871c9-ac65-4c7d-81c6-160651005ba6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MounjaroMember_47599e1d-4a03-45cd-9d5f-bfda0022d477" xlink:href="lly-20230930.xsd#lly_MounjaroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_MounjaroMember_47599e1d-4a03-45cd-9d5f-bfda0022d477" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_JardianceMember_a56d686c-cd28-4d4b-a5d1-45ca7eb6ce9d" xlink:href="lly-20230930.xsd#lly_JardianceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_JardianceMember_a56d686c-cd28-4d4b-a5d1-45ca7eb6ce9d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HumalogMember_62318563-9816-4a0a-a9ca-6d4d937ea188" xlink:href="lly-20230930.xsd#lly_HumalogMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_HumalogMember_62318563-9816-4a0a-a9ca-6d4d937ea188" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HumulinMember_4e6447cf-02c7-4f14-bdb4-496206e60809" xlink:href="lly-20230930.xsd#lly_HumulinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_HumulinMember_4e6447cf-02c7-4f14-bdb4-496206e60809" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BasaglarMember_f81d9080-f459-4a9e-bf12-f92737885671" xlink:href="lly-20230930.xsd#lly_BasaglarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_BasaglarMember_f81d9080-f459-4a9e-bf12-f92737885671" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BaqsimiMember_3ca10df1-6ff0-4440-acb3-fbe34a1d3358" xlink:href="lly-20230930.xsd#lly_BaqsimiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_BaqsimiMember_3ca10df1-6ff0-4440-acb3-fbe34a1d3358" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherDiabetesMember_4944e574-c460-4daf-856d-11fd28549130" xlink:href="lly-20230930.xsd#lly_OtherDiabetesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_DiabetesMember_447ff548-a8e6-4dfd-8978-7fe80e7f865a" xlink:to="loc_lly_OtherDiabetesMember_4944e574-c460-4daf-856d-11fd28549130" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:href="lly-20230930.xsd#lly_OncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:to="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_VerzenioMember_e4507ede-2c6a-4868-8bf6-93078f2d0f6d" xlink:href="lly-20230930.xsd#lly_VerzenioMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:to="loc_lly_VerzenioMember_e4507ede-2c6a-4868-8bf6-93078f2d0f6d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CyramzaMember_acec5483-485d-4c77-a158-2332bd8c1119" xlink:href="lly-20230930.xsd#lly_CyramzaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:to="loc_lly_CyramzaMember_acec5483-485d-4c77-a158-2332bd8c1119" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ErbituxMember_d668130c-a43c-46d5-bf30-efb51c59a223" xlink:href="lly-20230930.xsd#lly_ErbituxMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:to="loc_lly_ErbituxMember_d668130c-a43c-46d5-bf30-efb51c59a223" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_AlimtaMember_e5d78b7c-2379-4a4f-ad4d-a86233448e2b" xlink:href="lly-20230930.xsd#lly_AlimtaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:to="loc_lly_AlimtaMember_e5d78b7c-2379-4a4f-ad4d-a86233448e2b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherOncologyMember_aa8f2b94-594a-42d7-88eb-e21b3bf535d4" xlink:href="lly-20230930.xsd#lly_OtherOncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_a5429f61-9a75-471e-9fee-52438035b373" xlink:to="loc_lly_OtherOncologyMember_aa8f2b94-594a-42d7-88eb-e21b3bf535d4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ImmunologyMember_ede8de2b-73eb-4be6-9f7a-ff0b1dacc002" xlink:href="lly-20230930.xsd#lly_ImmunologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:to="loc_lly_ImmunologyMember_ede8de2b-73eb-4be6-9f7a-ff0b1dacc002" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TaltzMember_b1c95c0a-7914-41bd-b51d-8de90ae155fa" xlink:href="lly-20230930.xsd#lly_TaltzMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_ede8de2b-73eb-4be6-9f7a-ff0b1dacc002" xlink:to="loc_lly_TaltzMember_b1c95c0a-7914-41bd-b51d-8de90ae155fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_db2b4383-ac02-4b66-b53c-6d6695195866" xlink:href="lly-20230930.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_ede8de2b-73eb-4be6-9f7a-ff0b1dacc002" xlink:to="loc_lly_OlumiantMember_db2b4383-ac02-4b66-b53c-6d6695195866" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherImmunologyMember_b04e93be-3358-498e-b794-90629b487c31" xlink:href="lly-20230930.xsd#lly_OtherImmunologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_ede8de2b-73eb-4be6-9f7a-ff0b1dacc002" xlink:to="loc_lly_OtherImmunologyMember_b04e93be-3358-498e-b794-90629b487c31" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_NeuroscienceMember_95fad3c6-5394-4294-b4a4-04c81e245968" xlink:href="lly-20230930.xsd#lly_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:to="loc_lly_NeuroscienceMember_95fad3c6-5394-4294-b4a4-04c81e245968" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ZyprexaMember_912217e6-739a-48a9-8e77-528b3259e6ab" xlink:href="lly-20230930.xsd#lly_ZyprexaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_95fad3c6-5394-4294-b4a4-04c81e245968" xlink:to="loc_lly_ZyprexaMember_912217e6-739a-48a9-8e77-528b3259e6ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmgalityMember_0d8709fe-1a2b-4cb4-a3ec-cb211e3a768d" xlink:href="lly-20230930.xsd#lly_EmgalityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_95fad3c6-5394-4294-b4a4-04c81e245968" xlink:to="loc_lly_EmgalityMember_0d8709fe-1a2b-4cb4-a3ec-cb211e3a768d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherNeuroscienceMember_5787c6dc-5099-4efd-9394-43ce03a58711" xlink:href="lly-20230930.xsd#lly_OtherNeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_95fad3c6-5394-4294-b4a4-04c81e245968" xlink:to="loc_lly_OtherNeuroscienceMember_5787c6dc-5099-4efd-9394-43ce03a58711" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:href="lly-20230930.xsd#lly_OtherProductTotalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_93d54c5b-3dc5-4eed-8bc7-75bca5c06d47" xlink:to="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ForteoMember_ee2b78eb-baa7-46ba-871d-50674213b2f2" xlink:href="lly-20230930.xsd#lly_ForteoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:to="loc_lly_ForteoMember_ee2b78eb-baa7-46ba-871d-50674213b2f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CialisMember_7f306d69-e71c-4720-8d0e-036c91c892ed" xlink:href="lly-20230930.xsd#lly_CialisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:to="loc_lly_CialisMember_7f306d69-e71c-4720-8d0e-036c91c892ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_COVID19AntibodiesMember_730e1454-f85b-4568-9dbd-194e93de4b94" xlink:href="lly-20230930.xsd#lly_COVID19AntibodiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:to="loc_lly_COVID19AntibodiesMember_730e1454-f85b-4568-9dbd-194e93de4b94" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherProductMember_26049102-8e08-4585-93e3-7c6f2dbc7571" xlink:href="lly-20230930.xsd#lly_OtherProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_8b3f41de-c70f-49f9-8365-49f45babd148" xlink:to="loc_lly_OtherProductMember_26049102-8e08-4585-93e3-7c6f2dbc7571" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_f40c465d-6d28-4265-80fe-da3c82fc34b5" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_736e1972-f06d-42c7-bc97-e39e2b1bd3e8" xlink:to="loc_srt_StatementGeographicalAxis_f40c465d-6d28-4265-80fe-da3c82fc34b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_f40c465d-6d28-4265-80fe-da3c82fc34b5_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_f40c465d-6d28-4265-80fe-da3c82fc34b5" xlink:to="loc_srt_SegmentGeographicalDomain_f40c465d-6d28-4265-80fe-da3c82fc34b5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d1003793-5d6d-41fd-801a-cd09b4d0db95" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_f40c465d-6d28-4265-80fe-da3c82fc34b5" xlink:to="loc_srt_SegmentGeographicalDomain_d1003793-5d6d-41fd-801a-cd09b4d0db95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_e9198967-7e9c-40e5-97fe-1a4682d15b61" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d1003793-5d6d-41fd-801a-cd09b4d0db95" xlink:to="loc_country_US_e9198967-7e9c-40e5-97fe-1a4682d15b61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_68d4fef3-a61c-457a-980d-2ce865d17253" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d1003793-5d6d-41fd-801a-cd09b4d0db95" xlink:to="loc_us-gaap_NonUsMember_68d4fef3-a61c-457a-980d-2ce865d17253" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyGeographicalAreaDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#RevenueDisaggregationofRevenuebyGeographicalAreaDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyGeographicalAreaDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_a8394767-53bd-4113-b918-0963a3c63062" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_c2785f49-f091-4320-b9f6-4199c36a0708" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_a8394767-53bd-4113-b918-0963a3c63062" xlink:to="loc_us-gaap_Revenues_c2785f49-f091-4320-b9f6-4199c36a0708" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_e8146163-ec46-4e91-95b4-ca645fa4ffe5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_a8394767-53bd-4113-b918-0963a3c63062" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_e8146163-ec46-4e91-95b4-ca645fa4ffe5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_869939d0-02e2-405c-884d-fe42be88c0c7" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_e8146163-ec46-4e91-95b4-ca645fa4ffe5" xlink:to="loc_srt_StatementGeographicalAxis_869939d0-02e2-405c-884d-fe42be88c0c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_869939d0-02e2-405c-884d-fe42be88c0c7_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_869939d0-02e2-405c-884d-fe42be88c0c7" xlink:to="loc_srt_SegmentGeographicalDomain_869939d0-02e2-405c-884d-fe42be88c0c7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_869939d0-02e2-405c-884d-fe42be88c0c7" xlink:to="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_cc98b79e-6bff-499e-94c5-f2b7fc0c6c73" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:to="loc_country_US_cc98b79e-6bff-499e-94c5-f2b7fc0c6c73" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_b13db9e7-c9a5-41dc-a46a-f974bc76c1b3" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:to="loc_srt_EuropeMember_b13db9e7-c9a5-41dc-a46a-f974bc76c1b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_JP_f1c10563-7894-4c62-9da6-9c2d6b366a04" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_JP"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:to="loc_country_JP_f1c10563-7894-4c62-9da6-9c2d6b366a04" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CN_10f7b60d-6591-4907-8439-4737f99be0a5" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_CN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:to="loc_country_CN_10f7b60d-6591-4907-8439-4737f99be0a5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherForeignCountriesMember_30639f35-1d45-4c88-8bf0-00ac4fde25ed" xlink:href="lly-20230930.xsd#lly_OtherForeignCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9b9404c8-66e1-42ff-b363-df7cb561bf58" xlink:to="loc_lly_OtherForeignCountriesMember_30639f35-1d45-4c88-8bf0-00ac4fde25ed" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_6521c3a9-c4ec-4958-9984-a86020a8e1dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_6521c3a9-c4ec-4958-9984-a86020a8e1dd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_86185c3c-cacd-4483-a6f8-8a08fd8d5b10" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionSharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_BusinessAcquisitionSharePrice_86185c3c-cacd-4483-a6f8-8a08fd8d5b10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_02da36c9-cba1-4069-bbcf-c9b9c31e3485" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_02da36c9-cba1-4069-bbcf-c9b9c31e3485" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BusinessCombinationConsiderationTransferredNumberOfContingentValueRights_2acd3599-5f85-4580-a4a7-90c2246b47da" xlink:href="lly-20230930.xsd#lly_BusinessCombinationConsiderationTransferredNumberOfContingentValueRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_lly_BusinessCombinationConsiderationTransferredNumberOfContingentValueRights_2acd3599-5f85-4580-a4a7-90c2246b47da" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BusinessAcquisitionContingentValueRightAdditionalPricePerShare_509f2525-f1e5-4c89-af46-96a38ed7bb38" xlink:href="lly-20230930.xsd#lly_BusinessAcquisitionContingentValueRightAdditionalPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_lly_BusinessAcquisitionContingentValueRightAdditionalPricePerShare_509f2525-f1e5-4c89-af46-96a38ed7bb38" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_3b64290f-6d21-45d4-8a91-9ac64674e477" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsRangeOfOutcomesValueHigh_3b64290f-6d21-45d4-8a91-9ac64674e477" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_PaymentsForAssetAcquisitions_b98e2971-bef1-4357-badb-5d05564baafd" xlink:href="lly-20230930.xsd#lly_PaymentsForAssetAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_lly_PaymentsForAssetAcquisitions_b98e2971-bef1-4357-badb-5d05564baafd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_6f31b3e5-a016-4c24-acb8-134af1e6f9e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_6f31b3e5-a016-4c24-acb8-134af1e6f9e5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e248b7bb-68e8-47dc-9042-1068b5021ccc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_47da1d59-6b47-4817-91f0-a48f45f3dcaa" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e248b7bb-68e8-47dc-9042-1068b5021ccc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d2d59c76-6f28-4085-b107-b07e251d9846" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e248b7bb-68e8-47dc-9042-1068b5021ccc" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d2d59c76-6f28-4085-b107-b07e251d9846" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d2d59c76-6f28-4085-b107-b07e251d9846_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d2d59c76-6f28-4085-b107-b07e251d9846" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d2d59c76-6f28-4085-b107-b07e251d9846_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22c3f350-0420-4f3f-80f9-4a894f853f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d2d59c76-6f28-4085-b107-b07e251d9846" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22c3f350-0420-4f3f-80f9-4a894f853f5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_AkouosAcquisitionMember_38ddae56-4ac7-4828-b017-33c3efb9aa45" xlink:href="lly-20230930.xsd#lly_AkouosAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22c3f350-0420-4f3f-80f9-4a894f853f5c" xlink:to="loc_lly_AkouosAcquisitionMember_38ddae56-4ac7-4828-b017-33c3efb9aa45" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BiopharmaGlobalIncMember_4d7e6e03-9c44-44d7-83a7-b4a5a8036baa" xlink:href="lly-20230930.xsd#lly_BiopharmaGlobalIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22c3f350-0420-4f3f-80f9-4a894f853f5c" xlink:to="loc_lly_BiopharmaGlobalIncMember_4d7e6e03-9c44-44d7-83a7-b4a5a8036baa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_875d80d8-5217-4042-aa4e-b4766a98958a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e248b7bb-68e8-47dc-9042-1068b5021ccc" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_875d80d8-5217-4042-aa4e-b4766a98958a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_875d80d8-5217-4042-aa4e-b4766a98958a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_875d80d8-5217-4042-aa4e-b4766a98958a" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_875d80d8-5217-4042-aa4e-b4766a98958a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_0cc693ac-f9b9-4304-82e9-c237bdbc3221" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_875d80d8-5217-4042-aa4e-b4766a98958a" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_0cc693ac-f9b9-4304-82e9-c237bdbc3221" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_a29fd120-6bd6-4e40-a399-c0ae36e8cd08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_0cc693ac-f9b9-4304-82e9-c237bdbc3221" xlink:to="loc_us-gaap_SubsequentEventMember_a29fd120-6bd6-4e40-a399-c0ae36e8cd08" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3a72388c-10c0-4246-b14e-121619f08743" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3a72388c-10c0-4246-b14e-121619f08743" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_3ac63ead-0687-4f5e-9ffb-ee687b365247" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_3ac63ead-0687-4f5e-9ffb-ee687b365247" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_59dc800b-00f5-45de-b532-784aa5aed961" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_Goodwill_59dc800b-00f5-45de-b532-784aa5aed961" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_6787d2bd-35d7-43d7-ae12-96c1b23fac08" xlink:href="lly-20230930.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_6787d2bd-35d7-43d7-ae12-96c1b23fac08" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_ccd3f1a4-3f4e-4384-97fe-a9fc1108f591" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_ccd3f1a4-3f4e-4384-97fe-a9fc1108f591" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAcquiredFromAcquisition_95c69075-7cfb-4b22-9065-8e2900f3aa15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAcquiredFromAcquisition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_CashAcquiredFromAcquisition_95c69075-7cfb-4b22-9065-8e2900f3aa15" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_3173e3ed-5bdb-49a8-9b1f-14435e5640cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_3173e3ed-5bdb-49a8-9b1f-14435e5640cb" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_db464c56-64a5-4068-9d0f-8e80c4b3f214" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_db464c56-64a5-4068-9d0f-8e80c4b3f214" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_59e44b80-3a17-41a4-a43f-418f8e692976" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_70f0162d-79ca-45a1-b9fd-ae142094873c" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_59e44b80-3a17-41a4-a43f-418f8e692976" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_a80ee4b4-001a-4163-ac35-78de04b855c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_59e44b80-3a17-41a4-a43f-418f8e692976" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_a80ee4b4-001a-4163-ac35-78de04b855c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_a80ee4b4-001a-4163-ac35-78de04b855c9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_a80ee4b4-001a-4163-ac35-78de04b855c9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_a80ee4b4-001a-4163-ac35-78de04b855c9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ee1bbc33-37d4-4c3b-bff7-c627ea982352" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_a80ee4b4-001a-4163-ac35-78de04b855c9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ee1bbc33-37d4-4c3b-bff7-c627ea982352" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_AkouosAcquisitionMember_a99fbf68-5c49-45a8-a02c-503a9f8127bd" xlink:href="lly-20230930.xsd#lly_AkouosAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ee1bbc33-37d4-4c3b-bff7-c627ea982352" xlink:to="loc_lly_AkouosAcquisitionMember_a99fbf68-5c49-45a8-a02c-503a9f8127bd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAssetAcquisitionsDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#AcquisitionsAssetAcquisitionsDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAssetAcquisitionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_81a757cc-39ed-47ff-b459-b516e8cd180a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_PaymentsForAssetAcquisitions_fa030aa6-e5b4-49e9-9f20-028cf0b626a9" xlink:href="lly-20230930.xsd#lly_PaymentsForAssetAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_81a757cc-39ed-47ff-b459-b516e8cd180a" xlink:to="loc_lly_PaymentsForAssetAcquisitions_fa030aa6-e5b4-49e9-9f20-028cf0b626a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_e87ef81a-7e71-4855-aae5-7760ea584fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_81a757cc-39ed-47ff-b459-b516e8cd180a" xlink:to="loc_us-gaap_AssetAcquisitionTable_e87ef81a-7e71-4855-aae5-7760ea584fdf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_6942543d-189e-43d8-a936-7b1ecdf1e9a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_e87ef81a-7e71-4855-aae5-7760ea584fdf" xlink:to="loc_us-gaap_AssetAcquisitionAxis_6942543d-189e-43d8-a936-7b1ecdf1e9a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_6942543d-189e-43d8-a936-7b1ecdf1e9a7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_6942543d-189e-43d8-a936-7b1ecdf1e9a7" xlink:to="loc_us-gaap_AssetAcquisitionDomain_6942543d-189e-43d8-a936-7b1ecdf1e9a7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_6942543d-189e-43d8-a936-7b1ecdf1e9a7" xlink:to="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DICETherapeuticsIncMember_1e81c811-3ad8-49f9-a5e8-dd78fc4f38be" xlink:href="lly-20230930.xsd#lly_DICETherapeuticsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:to="loc_lly_DICETherapeuticsIncMember_1e81c811-3ad8-49f9-a5e8-dd78fc4f38be" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_VersanisBioIncMember_2b49e5da-e72b-4fa8-99e0-cb8fda20465c" xlink:href="lly-20230930.xsd#lly_VersanisBioIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:to="loc_lly_VersanisBioIncMember_2b49e5da-e72b-4fa8-99e0-cb8fda20465c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmergenceTherapeuticsMember_9f55fbdd-7bc3-4a3f-b793-e5b46243d162" xlink:href="lly-20230930.xsd#lly_EmergenceTherapeuticsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:to="loc_lly_EmergenceTherapeuticsMember_9f55fbdd-7bc3-4a3f-b793-e5b46243d162" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BioMarinPharmaceuticalIncMember_b62f6cb1-3a06-4e62-8908-5389c3214f41" xlink:href="lly-20230930.xsd#lly_BioMarinPharmaceuticalIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_3b56e837-e3e8-4a6d-812a-d63063012a53" xlink:to="loc_lly_BioMarinPharmaceuticalIncMember_b62f6cb1-3a06-4e62-8908-5389c3214f41" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsandOtherArrangementsMilestonesDeferredCapitalizedDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#CollaborationsandOtherArrangementsMilestonesDeferredCapitalizedDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsandOtherArrangementsMilestonesDeferredCapitalizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_bfc90e20-5ed0-4aac-afff-4e3ab77e1aa7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_934433bc-3f46-4301-99b9-2f9ebcfbedda" xlink:href="lly-20230930.xsd#lly_CollaborativeArrangementRightsAndObligationsRightsObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_bfc90e20-5ed0-4aac-afff-4e3ab77e1aa7" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_934433bc-3f46-4301-99b9-2f9ebcfbedda" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_ac7f09b7-2113-4159-9e5e-feeece3e6bf2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_bfc90e20-5ed0-4aac-afff-4e3ab77e1aa7" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_ac7f09b7-2113-4159-9e5e-feeece3e6bf2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_82a65a8e-072e-47de-b2de-603564705587" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_ac7f09b7-2113-4159-9e5e-feeece3e6bf2" xlink:to="loc_srt_ProductOrServiceAxis_82a65a8e-072e-47de-b2de-603564705587" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_82a65a8e-072e-47de-b2de-603564705587_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_82a65a8e-072e-47de-b2de-603564705587" xlink:to="loc_srt_ProductsAndServicesDomain_82a65a8e-072e-47de-b2de-603564705587_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_bcc7a2ff-af86-47e6-a612-e30ef5926624" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_82a65a8e-072e-47de-b2de-603564705587" xlink:to="loc_srt_ProductsAndServicesDomain_bcc7a2ff-af86-47e6-a612-e30ef5926624" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_JardianceMember_d5fab891-1904-4ff9-94e9-91081915818e" xlink:href="lly-20230930.xsd#lly_JardianceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_bcc7a2ff-af86-47e6-a612-e30ef5926624" xlink:to="loc_lly_JardianceMember_d5fab891-1904-4ff9-94e9-91081915818e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TrajentaBIMember_a50b8325-4361-42ca-b3de-4c2b59e83bab" xlink:href="lly-20230930.xsd#lly_TrajentaBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_bcc7a2ff-af86-47e6-a612-e30ef5926624" xlink:to="loc_lly_TrajentaBIMember_a50b8325-4361-42ca-b3de-4c2b59e83bab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BasaglarMember_644231e3-c1a3-4a37-9ea0-19e134d26720" xlink:href="lly-20230930.xsd#lly_BasaglarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_bcc7a2ff-af86-47e6-a612-e30ef5926624" xlink:to="loc_lly_BasaglarMember_644231e3-c1a3-4a37-9ea0-19e134d26720" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_0727ff5b-4228-46ab-943b-6910bd747a74" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_ac7f09b7-2113-4159-9e5e-feeece3e6bf2" xlink:to="loc_us-gaap_TypeOfArrangementAxis_0727ff5b-4228-46ab-943b-6910bd747a74" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0727ff5b-4228-46ab-943b-6910bd747a74_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_0727ff5b-4228-46ab-943b-6910bd747a74" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0727ff5b-4228-46ab-943b-6910bd747a74_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5a0398b7-8384-43e7-9ef4-0ceb1639ab31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_0727ff5b-4228-46ab-943b-6910bd747a74" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5a0398b7-8384-43e7-9ef4-0ceb1639ab31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_f9f54036-2a1f-4000-ba75-7c8208a90582" xlink:href="lly-20230930.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5a0398b7-8384-43e7-9ef4-0ceb1639ab31" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_f9f54036-2a1f-4000-ba75-7c8208a90582" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsandOtherArrangementsNetProductRevenueDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#CollaborationsandOtherArrangementsNetProductRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsandOtherArrangementsNetProductRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_691bbfac-818d-4132-bfb7-652b835cb2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_a514967f-b84d-43e4-b3da-2b8033c700ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_691bbfac-818d-4132-bfb7-652b835cb2fe" xlink:to="loc_us-gaap_Revenues_a514967f-b84d-43e4-b3da-2b8033c700ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_de9ed5d5-acb9-47ae-b35c-f77e359430e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_691bbfac-818d-4132-bfb7-652b835cb2fe" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_de9ed5d5-acb9-47ae-b35c-f77e359430e5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_8f8048f5-8176-47e2-a159-139d2bc89ea3" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_de9ed5d5-acb9-47ae-b35c-f77e359430e5" xlink:to="loc_srt_ProductOrServiceAxis_8f8048f5-8176-47e2-a159-139d2bc89ea3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_8f8048f5-8176-47e2-a159-139d2bc89ea3_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_8f8048f5-8176-47e2-a159-139d2bc89ea3" xlink:to="loc_srt_ProductsAndServicesDomain_8f8048f5-8176-47e2-a159-139d2bc89ea3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_8f8048f5-8176-47e2-a159-139d2bc89ea3" xlink:to="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_JardianceMember_0de35eba-242d-4e4c-bafd-3c5197308879" xlink:href="lly-20230930.xsd#lly_JardianceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:to="loc_lly_JardianceMember_0de35eba-242d-4e4c-bafd-3c5197308879" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BasaglarMember_d5398fc2-dee2-4b28-820d-4504def63224" xlink:href="lly-20230930.xsd#lly_BasaglarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:to="loc_lly_BasaglarMember_d5398fc2-dee2-4b28-820d-4504def63224" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TrajentaBIMember_9c1f516b-50c5-4805-83a3-747685959082" xlink:href="lly-20230930.xsd#lly_TrajentaBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:to="loc_lly_TrajentaBIMember_9c1f516b-50c5-4805-83a3-747685959082" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_0138a077-7a22-43da-b804-62b5bd9fd63e" xlink:href="lly-20230930.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1f81f849-3979-4729-8a31-270791a8a71b" xlink:to="loc_lly_OlumiantMember_0138a077-7a22-43da-b804-62b5bd9fd63e" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsandOtherArrangementsNarrativeDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#CollaborationsandOtherArrangementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsandOtherArrangementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_0b68b6f4-0e5a-4074-b78c-90a5b54ce363" xlink:href="lly-20230930.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_0b68b6f4-0e5a-4074-b78c-90a5b54ce363" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_0684be79-71ae-4bde-8e93-b83d134a965c" xlink:href="lly-20230930.xsd#lly_CollaborativeArrangementRightsAndObligationsRightsObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_0684be79-71ae-4bde-8e93-b83d134a965c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9be4172b-2eb0-48c4-a910-6be56f761936" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_us-gaap_Revenues_9be4172b-2eb0-48c4-a910-6be56f761936" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_688d2059-b1c2-4ba6-a9fc-8766ec3a1b78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_688d2059-b1c2-4ba6-a9fc-8766ec3a1b78" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_aa166f0f-eedc-43b0-a030-d63ef4cb5d31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_aa166f0f-eedc-43b0-a030-d63ef4cb5d31" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived_9d4a9c7f-7d4c-43ef-86db-8eb1456d1799" xlink:href="lly-20230930.xsd#lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived_9d4a9c7f-7d4c-43ef-86db-8eb1456d1799" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_e86b0cb9-3040-497e-8bf0-605c0089cdd5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_e86b0cb9-3040-497e-8bf0-605c0089cdd5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_910cb0be-c8ec-46b4-960d-4967dbe3c4b0" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:to="loc_us-gaap_TypeOfArrangementAxis_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_bfb9c7f1-b5e6-4f64-a9ff-17cbd9d932d1" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_ed4fadf9-4653-4aed-b12f-0dd8fb7518a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RoyaltyAgreementTermsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_ed4fadf9-4653-4aed-b12f-0dd8fb7518a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsCapitalizedAsIntangibleAssetsMember_129f25ad-a953-42c6-94e6-d640dd96c4d1" xlink:href="lly-20230930.xsd#lly_MilestonePaymentsCapitalizedAsIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:to="loc_lly_MilestonePaymentsCapitalizedAsIntangibleAssetsMember_129f25ad-a953-42c6-94e6-d640dd96c4d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_cb956290-1850-4eb4-8134-6c20703828f5" xlink:href="lly-20230930.xsd#lly_MilestonePaymentsSalesBasedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_cb956290-1850-4eb4-8134-6c20703828f5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_ffaacf76-b98a-42a4-b627-23e23734c216" xlink:href="lly-20230930.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_59c380dc-a5c0-4153-87ed-8afba6f695e3" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_ffaacf76-b98a-42a4-b627-23e23734c216" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_56c81994-217d-470d-824c-c2cff91f1f3f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:to="loc_srt_ProductOrServiceAxis_56c81994-217d-470d-824c-c2cff91f1f3f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_56c81994-217d-470d-824c-c2cff91f1f3f_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_56c81994-217d-470d-824c-c2cff91f1f3f" xlink:to="loc_srt_ProductsAndServicesDomain_56c81994-217d-470d-824c-c2cff91f1f3f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6b712aa5-a101-4d92-9570-7022cd86fd90" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_56c81994-217d-470d-824c-c2cff91f1f3f" xlink:to="loc_srt_ProductsAndServicesDomain_6b712aa5-a101-4d92-9570-7022cd86fd90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_d11daad1-0fc9-4dd5-9753-fe60d924d42e" xlink:href="lly-20230930.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6b712aa5-a101-4d92-9570-7022cd86fd90" xlink:to="loc_lly_OlumiantMember_d11daad1-0fc9-4dd5-9753-fe60d924d42e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_COVID19AntibodiesMember_5e2cb84d-56ff-437b-ad9a-38f095703edc" xlink:href="lly-20230930.xsd#lly_COVID19AntibodiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6b712aa5-a101-4d92-9570-7022cd86fd90" xlink:to="loc_lly_COVID19AntibodiesMember_5e2cb84d-56ff-437b-ad9a-38f095703edc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_LebrikizumabMember_fe01c869-8018-4b78-8fa7-93f8219c5631" xlink:href="lly-20230930.xsd#lly_LebrikizumabMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6b712aa5-a101-4d92-9570-7022cd86fd90" xlink:to="loc_lly_LebrikizumabMember_fe01c869-8018-4b78-8fa7-93f8219c5631" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_f76060de-b8be-4512-b9ba-6473457c4d27" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:to="loc_dei_LegalEntityAxis_f76060de-b8be-4512-b9ba-6473457c4d27" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_f76060de-b8be-4512-b9ba-6473457c4d27_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_f76060de-b8be-4512-b9ba-6473457c4d27" xlink:to="loc_dei_EntityDomain_f76060de-b8be-4512-b9ba-6473457c4d27_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_5421e378-2611-4198-abb0-7595b2619a65" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_f76060de-b8be-4512-b9ba-6473457c4d27" xlink:to="loc_dei_EntityDomain_5421e378-2611-4198-abb0-7595b2619a65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_RocheMember_70840b20-585e-4d8d-8928-df07f4c4e2dd" xlink:href="lly-20230930.xsd#lly_RocheMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5421e378-2611-4198-abb0-7595b2619a65" xlink:to="loc_lly_RocheMember_70840b20-585e-4d8d-8928-df07f4c4e2dd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_ffa12518-4456-4bbe-bcc1-51786c73b5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_ffa12518-4456-4bbe-bcc1-51786c73b5b3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_ffa12518-4456-4bbe-bcc1-51786c73b5b3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_ffa12518-4456-4bbe-bcc1-51786c73b5b3" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_ffa12518-4456-4bbe-bcc1-51786c73b5b3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_8c6abcb0-a2f7-4aeb-9830-b714885f4ec3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_ffa12518-4456-4bbe-bcc1-51786c73b5b3" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_8c6abcb0-a2f7-4aeb-9830-b714885f4ec3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_f44eb434-cb29-429c-9f87-5b41d9b4b1d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_8c6abcb0-a2f7-4aeb-9830-b714885f4ec3" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_f44eb434-cb29-429c-9f87-5b41d9b4b1d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ec352954-f1e5-40a8-a618-f9ca17b6471c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_813c3431-ebbd-43fc-875f-ae34c0a509ca" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ec352954-f1e5-40a8-a618-f9ca17b6471c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_ec352954-f1e5-40a8-a618-f9ca17b6471c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ec352954-f1e5-40a8-a618-f9ca17b6471c" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_ec352954-f1e5-40a8-a618-f9ca17b6471c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_df634c00-38bf-400f-b4ea-4d93860ff8da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ec352954-f1e5-40a8-a618-f9ca17b6471c" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_df634c00-38bf-400f-b4ea-4d93860ff8da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlanzapinePortfolioMember_1d1f2be4-8ea8-4571-ae3c-e0bb610e7a56" xlink:href="lly-20230930.xsd#lly_OlanzapinePortfolioMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_df634c00-38bf-400f-b4ea-4d93860ff8da" xlink:to="loc_lly_OlanzapinePortfolioMember_1d1f2be4-8ea8-4571-ae3c-e0bb610e7a56" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BaqsimiMember_0281e10d-00be-4c50-86ee-3e085ffac40f" xlink:href="lly-20230930.xsd#lly_BaqsimiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_df634c00-38bf-400f-b4ea-4d93860ff8da" xlink:to="loc_lly_BaqsimiMember_0281e10d-00be-4c50-86ee-3e085ffac40f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_7da3e1c9-d478-4f0a-a093-ada8ff690651" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_7da3e1c9-d478-4f0a-a093-ada8ff690651" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments_85a0302f-00d9-422c-9964-a3c98d0b9299" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments_85a0302f-00d9-422c-9964-a3c98d0b9299" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod_b284dff7-fb36-415f-851f-8444f0e0a0d4" xlink:href="lly-20230930.xsd#lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod_b284dff7-fb36-415f-851f-8444f0e0a0d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DebtSecuritiesAvailableForSaleUnrealizedLossPositionQualitativeDisclosureOtherPercentageOfNonperformingAssets_956e1274-5a21-434f-8f52-5f50ff0d68a2" xlink:href="lly-20230930.xsd#lly_DebtSecuritiesAvailableForSaleUnrealizedLossPositionQualitativeDisclosureOtherPercentageOfNonperformingAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_lly_DebtSecuritiesAvailableForSaleUnrealizedLossPositionQualitativeDisclosureOtherPercentageOfNonperformingAssets_956e1274-5a21-434f-8f52-5f50ff0d68a2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_a68e0a23-e520-4555-9bcb-b54b1ea409d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_a68e0a23-e520-4555-9bcb-b54b1ea409d4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_8e707d34-1828-4bd4-9e43-29204391c380" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_8e707d34-1828-4bd4-9e43-29204391c380" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_844cbdbd-68dc-4c25-834e-ccbf1e9d716e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_844cbdbd-68dc-4c25-834e-ccbf1e9d716e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_0b436f86-a088-4d3e-af27-18866eaed06b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_0b436f86-a088-4d3e-af27-18866eaed06b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_db0d2629-4822-49f7-98e2-25213b9a6ccb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DebtInstrumentTerm_db0d2629-4822-49f7-98e2-25213b9a6ccb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_65ec0ecc-340d-4d85-af45-2428fd5f0283" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_65ec0ecc-340d-4d85-af45-2428fd5f0283" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_8c55d2ed-3242-4b06-aa44-66c844b29a3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_8c55d2ed-3242-4b06-aa44-66c844b29a3e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_599b4c3a-35cf-4e56-a5ab-f52396ef5413" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_599b4c3a-35cf-4e56-a5ab-f52396ef5413" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_e0690fcc-5bd0-460b-8f6e-77c04e5422a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_LongTermDebt_e0690fcc-5bd0-460b-8f6e-77c04e5422a9" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_4c9e0a58-32b6-44b4-ac71-8d54e2ad396f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_4c9e0a58-32b6-44b4-ac71-8d54e2ad396f" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_93fc1c21-7f17-4527-a663-90c71f21345b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_93fc1c21-7f17-4527-a663-90c71f21345b" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_1b86b3d2-ec00-4b58-bc54-2982f0b13cca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_1b86b3d2-ec00-4b58-bc54-2982f0b13cca" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_49f2d127-a2d6-470c-838b-da69495d1277" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_49f2d127-a2d6-470c-838b-da69495d1277" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_2899f6c8-ee88-4d21-b0b5-8d944eaa92de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_DerivativeNotionalAmount_2899f6c8-ee88-4d21-b0b5-8d944eaa92de" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_d003a391-8f4d-4924-a93f-eff1c14d1b1f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_d003a391-8f4d-4924-a93f-eff1c14d1b1f" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a1bf5c73-b6a6-48e9-ba94-5933197952a1" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_4c967950-6d05-4d09-829f-9e108b4fef63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_DebtInstrumentAxis_4c967950-6d05-4d09-829f-9e108b4fef63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4c967950-6d05-4d09-829f-9e108b4fef63_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_4c967950-6d05-4d09-829f-9e108b4fef63" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4c967950-6d05-4d09-829f-9e108b4fef63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_4c967950-6d05-4d09-829f-9e108b4fef63" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A50NotesDue2026Member_9a0767b3-7825-4a78-9332-adb65d383af4" xlink:href="lly-20230930.xsd#lly_A50NotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_A50NotesDue2026Member_9a0767b3-7825-4a78-9332-adb65d383af4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A47NotesDue2033Member_e7596d7f-305a-4fd0-ab29-a4c784d97816" xlink:href="lly-20230930.xsd#lly_A47NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_A47NotesDue2033Member_e7596d7f-305a-4fd0-ab29-a4c784d97816" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A4875NotesDue2053Member_7c8a115f-1c80-42d7-9aa6-66d04df0732b" xlink:href="lly-20230930.xsd#lly_A4875NotesDue2053Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_A4875NotesDue2053Member_7c8a115f-1c80-42d7-9aa6-66d04df0732b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A495NotesDue2063Member_fb25f820-a77c-44b5-b722-c8d930284eeb" xlink:href="lly-20230930.xsd#lly_A495NotesDue2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_A495NotesDue2063Member_fb25f820-a77c-44b5-b722-c8d930284eeb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SeniorNotesDue202620332053And2063Member_fc7a46fe-f976-4051-a343-7d2d4ef53980" xlink:href="lly-20230930.xsd#lly_SeniorNotesDue202620332053And2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_SeniorNotesDue202620332053And2063Member_fc7a46fe-f976-4051-a343-7d2d4ef53980" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CreditFacility2024Member_3eb0cc7e-2303-48a5-b394-f52c1497af49" xlink:href="lly-20230930.xsd#lly_CreditFacility2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0f2f48cb-b5e2-48c4-8f84-381f02031213" xlink:to="loc_lly_CreditFacility2024Member_3eb0cc7e-2303-48a5-b394-f52c1497af49" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_28f9783d-8e53-4094-a3f1-366dd933f9a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c6a5ba8b-042d-4f42-ab9a-2c24cacb6f08" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_28f9783d-8e53-4094-a3f1-366dd933f9a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_38205fe3-725d-452f-a8e5-0fb061e53f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_28f9783d-8e53-4094-a3f1-366dd933f9a9" xlink:to="loc_us-gaap_SeniorNotesMember_38205fe3-725d-452f-a8e5-0fb061e53f7b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ForeignCurrencyDenominatedDebtMember_f89acd3c-3116-4f1e-a4f4-2ae360ec6fa9" xlink:href="lly-20230930.xsd#lly_ForeignCurrencyDenominatedDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_28f9783d-8e53-4094-a3f1-366dd933f9a9" xlink:to="loc_lly_ForeignCurrencyDenominatedDebtMember_f89acd3c-3116-4f1e-a4f4-2ae360ec6fa9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_7ffb1d54-2db3-4500-9a73-9d2a842f1099" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_7ffb1d54-2db3-4500-9a73-9d2a842f1099" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_7ffb1d54-2db3-4500-9a73-9d2a842f1099_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_7ffb1d54-2db3-4500-9a73-9d2a842f1099" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_7ffb1d54-2db3-4500-9a73-9d2a842f1099_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_7ffb1d54-2db3-4500-9a73-9d2a842f1099" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SwapU.S.DollarsToEuroMember_403e3485-264d-4661-a23b-a5816bc16780" xlink:href="lly-20230930.xsd#lly_SwapU.S.DollarsToEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:to="loc_lly_SwapU.S.DollarsToEuroMember_403e3485-264d-4661-a23b-a5816bc16780" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SwapSwissFrancsToU.S.DollarsMember_02e71a30-5f81-45f3-b64e-d7c4c57e4a7b" xlink:href="lly-20230930.xsd#lly_SwapSwissFrancsToU.S.DollarsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:to="loc_lly_SwapSwissFrancsToU.S.DollarsMember_02e71a30-5f81-45f3-b64e-d7c4c57e4a7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SellEuroMember_5cdf8d4c-32c4-4a0f-bf58-55d0d7323ccd" xlink:href="lly-20230930.xsd#lly_SellEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:to="loc_lly_SellEuroMember_5cdf8d4c-32c4-4a0f-bf58-55d0d7323ccd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SellChineseYuanMember_13858425-c177-4611-8634-a7db67abbe76" xlink:href="lly-20230930.xsd#lly_SellChineseYuanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:to="loc_lly_SellChineseYuanMember_13858425-c177-4611-8634-a7db67abbe76" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_f5f577d5-6800-4c21-96e9-2265e6169142" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_210e12df-da2c-4122-a097-d1747ecb8394" xlink:to="loc_us-gaap_InterestRateSwapMember_f5f577d5-6800-4c21-96e9-2265e6169142" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_535845b2-ea4c-4281-b0c3-5daf3421419d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_535845b2-ea4c-4281-b0c3-5daf3421419d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_535845b2-ea4c-4281-b0c3-5daf3421419d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_535845b2-ea4c-4281-b0c3-5daf3421419d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_535845b2-ea4c-4281-b0c3-5daf3421419d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_2b73c4cc-9d24-495f-a227-2a56e7bc00a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_535845b2-ea4c-4281-b0c3-5daf3421419d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_2b73c4cc-9d24-495f-a227-2a56e7bc00a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_3183628b-6e02-4113-826e-cab05d16ad2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_2b73c4cc-9d24-495f-a227-2a56e7bc00a6" xlink:to="loc_us-gaap_CashFlowHedgingMember_3183628b-6e02-4113-826e-cab05d16ad2f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_212c685d-f130-4b52-9e1c-f20a307fcb36" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_HedgingDesignationAxis_212c685d-f130-4b52-9e1c-f20a307fcb36" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_212c685d-f130-4b52-9e1c-f20a307fcb36_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_212c685d-f130-4b52-9e1c-f20a307fcb36" xlink:to="loc_us-gaap_HedgingDesignationDomain_212c685d-f130-4b52-9e1c-f20a307fcb36_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_6ad27044-9803-4238-8df5-9124573b8f71" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_212c685d-f130-4b52-9e1c-f20a307fcb36" xlink:to="loc_us-gaap_HedgingDesignationDomain_6ad27044-9803-4238-8df5-9124573b8f71" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2d1c5683-fe66-4043-bbac-ed7e9ddb8230" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_6ad27044-9803-4238-8df5-9124573b8f71" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2d1c5683-fe66-4043-bbac-ed7e9ddb8230" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_e7220a66-8ba3-4b30-b2b7-f27064eead72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_e7220a66-8ba3-4b30-b2b7-f27064eead72" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_e7220a66-8ba3-4b30-b2b7-f27064eead72_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_e7220a66-8ba3-4b30-b2b7-f27064eead72" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_e7220a66-8ba3-4b30-b2b7-f27064eead72_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_567db640-fc9e-4539-961c-2a07df4c758a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_e7220a66-8ba3-4b30-b2b7-f27064eead72" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_567db640-fc9e-4539-961c-2a07df4c758a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MaturityDate2024Member_da25c771-2de8-4cc0-b5be-e2b2c4c6bf1e" xlink:href="lly-20230930.xsd#lly_MaturityDate2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_567db640-fc9e-4539-961c-2a07df4c758a" xlink:to="loc_lly_MaturityDate2024Member_da25c771-2de8-4cc0-b5be-e2b2c4c6bf1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_231d02b8-7fe6-4c47-813e-1c4ef7de1646" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_7694e765-6167-4c24-aac5-de71ce0bfd94" xlink:to="loc_us-gaap_CreditFacilityAxis_231d02b8-7fe6-4c47-813e-1c4ef7de1646" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_231d02b8-7fe6-4c47-813e-1c4ef7de1646_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_231d02b8-7fe6-4c47-813e-1c4ef7de1646" xlink:to="loc_us-gaap_CreditFacilityDomain_231d02b8-7fe6-4c47-813e-1c4ef7de1646_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_576d2a71-1cd5-4270-8183-514ba6d3f216" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_231d02b8-7fe6-4c47-813e-1c4ef7de1646" xlink:to="loc_us-gaap_CreditFacilityDomain_576d2a71-1cd5-4270-8183-514ba6d3f216" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_8475fdaf-5e4a-4f53-a480-e883b2af941e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_576d2a71-1cd5-4270-8183-514ba6d3f216" xlink:to="loc_us-gaap_LineOfCreditMember_8475fdaf-5e4a-4f53-a480-e883b2af941e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofFairValueMeasurementDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsScheduleofFairValueMeasurementDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofFairValueMeasurementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f8e287cb-9cd1-4342-a307-e76e694d1c72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f8e287cb-9cd1-4342-a307-e76e694d1c72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_fea37f28-2a56-4356-8b90-f917f8bb5950" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_fea37f28-2a56-4356-8b90-f917f8bb5950" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_a37fb8ce-8472-402b-8571-904e9739e266" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_a37fb8ce-8472-402b-8571-904e9739e266" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_1e5c584c-7229-4ce0-ade2-3d931dc15ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_1e5c584c-7229-4ce0-ade2-3d931dc15ed7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_07f463db-51da-4b77-aa7d-9c0cc5d5703f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_07f463db-51da-4b77-aa7d-9c0cc5d5703f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_5cf13c4c-723e-41c2-9711-89d07e91fd7a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_EquityMethodInvestments_5cf13c4c-723e-41c2-9711-89d07e91fd7a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_05b94eec-7f88-4f80-9304-82be0fe998c6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_LongTermInvestments_05b94eec-7f88-4f80-9304-82be0fe998c6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2ba0b8a8-10ac-4d33-a809-ce85afbd7002" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_8c085c37-cad9-40d6-b4ee-f450a279a98e" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2ba0b8a8-10ac-4d33-a809-ce85afbd7002" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_ee269242-5a91-4df2-b5c3-fbcd68498c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2ba0b8a8-10ac-4d33-a809-ce85afbd7002" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_ee269242-5a91-4df2-b5c3-fbcd68498c7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ee269242-5a91-4df2-b5c3-fbcd68498c7f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_ee269242-5a91-4df2-b5c3-fbcd68498c7f" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ee269242-5a91-4df2-b5c3-fbcd68498c7f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_ee269242-5a91-4df2-b5c3-fbcd68498c7f" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2a77b4ce-72e3-4e39-b80e-bb3eca8e982c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2a77b4ce-72e3-4e39-b80e-bb3eca8e982c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_174fcec8-c575-430c-b527-5fa83d93b1b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_174fcec8-c575-430c-b527-5fa83d93b1b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_937fb263-72b1-49ed-8f5f-9ad523874291" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_937fb263-72b1-49ed-8f5f-9ad523874291" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_27861141-5573-408a-808d-534761f21d8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_621d7820-a46a-4f9f-af1d-d02e8f8ef418" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_27861141-5573-408a-808d-534761f21d8c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0f76eb47-0cc5-4800-9e9d-7413e600d170" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2ba0b8a8-10ac-4d33-a809-ce85afbd7002" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0f76eb47-0cc5-4800-9e9d-7413e600d170" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0f76eb47-0cc5-4800-9e9d-7413e600d170_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0f76eb47-0cc5-4800-9e9d-7413e600d170" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0f76eb47-0cc5-4800-9e9d-7413e600d170_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_039936d8-0313-4222-a5ed-76de412d9771" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0f76eb47-0cc5-4800-9e9d-7413e600d170" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_039936d8-0313-4222-a5ed-76de412d9771" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_dba54644-fa7f-4c93-9d56-e2d2da3706ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_039936d8-0313-4222-a5ed-76de412d9771" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_dba54644-fa7f-4c93-9d56-e2d2da3706ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_92dcf033-57ac-4ab6-8505-07a7f64434b0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_039936d8-0313-4222-a5ed-76de412d9771" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_92dcf033-57ac-4ab6-8505-07a7f64434b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_32975d83-bb77-48d8-b3a8-d775c744d0c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_039936d8-0313-4222-a5ed-76de412d9771" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_32975d83-bb77-48d8-b3a8-d775c744d0c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_591368f0-32eb-4f7c-bd3c-e962d06a9dd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2ba0b8a8-10ac-4d33-a809-ce85afbd7002" xlink:to="loc_us-gaap_FinancialInstrumentAxis_591368f0-32eb-4f7c-bd3c-e962d06a9dd7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_591368f0-32eb-4f7c-bd3c-e962d06a9dd7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_591368f0-32eb-4f7c-bd3c-e962d06a9dd7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_591368f0-32eb-4f7c-bd3c-e962d06a9dd7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_591368f0-32eb-4f7c-bd3c-e962d06a9dd7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_f30481dd-139a-48dc-9136-2dff67d53a07" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_f30481dd-139a-48dc-9136-2dff67d53a07" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_1f04ea84-14be-4e32-a7dc-91e1bd8f1f21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_1f04ea84-14be-4e32-a7dc-91e1bd8f1f21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_431b5831-b1db-4a22-b30f-c2f540bc4209" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MortgageBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_431b5831-b1db-4a22-b30f-c2f540bc4209" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_5068b5d2-22e2-4bea-953b-1d50b19e68b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_5068b5d2-22e2-4bea-953b-1d50b19e68b8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_058db7cd-0f72-41f2-afc8-7b99931ceb4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_058db7cd-0f72-41f2-afc8-7b99931ceb4f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherEquitySecuritiesMember_6375b684-12d9-4396-a725-dab6a4d3b3ca" xlink:href="lly-20230930.xsd#lly_OtherEquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_lly_OtherEquitySecuritiesMember_6375b684-12d9-4396-a725-dab6a4d3b3ca" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MarketableSecuritiesMember_f9bba63e-8ab9-4b00-b318-309cd6e1dec0" xlink:href="lly-20230930.xsd#lly_MarketableSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b21763b5-7032-4270-8b6e-d9aa4806e7af" xlink:to="loc_lly_MarketableSecuritiesMember_f9bba63e-8ab9-4b00-b318-309cd6e1dec0" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f4529f6a-717b-4465-9352-a4bcf1bce5c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaper_30f76ebd-64d9-40f8-b296-4c5a0530677d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaper"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f4529f6a-717b-4465-9352-a4bcf1bce5c9" xlink:to="loc_us-gaap_CommercialPaper_30f76ebd-64d9-40f8-b296-4c5a0530677d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_a81abe57-4485-49de-8732-f84a7ed9a785" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f4529f6a-717b-4465-9352-a4bcf1bce5c9" xlink:to="loc_us-gaap_LongTermDebt_a81abe57-4485-49de-8732-f84a7ed9a785" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8256e6f0-aff0-470a-9d76-3d809083c559" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f4529f6a-717b-4465-9352-a4bcf1bce5c9" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8256e6f0-aff0-470a-9d76-3d809083c559" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_a3305199-7fcc-4754-a35b-f275a0d453cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8256e6f0-aff0-470a-9d76-3d809083c559" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_a3305199-7fcc-4754-a35b-f275a0d453cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_a3305199-7fcc-4754-a35b-f275a0d453cd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_a3305199-7fcc-4754-a35b-f275a0d453cd" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_a3305199-7fcc-4754-a35b-f275a0d453cd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_b1800966-cbbf-4eb7-b940-f29326b0dd3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_a3305199-7fcc-4754-a35b-f275a0d453cd" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_b1800966-cbbf-4eb7-b940-f29326b0dd3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2dcbc616-5bae-4920-aa20-086cca7c7447" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_b1800966-cbbf-4eb7-b940-f29326b0dd3c" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2dcbc616-5bae-4920-aa20-086cca7c7447" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_0778300e-3c5b-4feb-b8bc-5172f7287332" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_b1800966-cbbf-4eb7-b940-f29326b0dd3c" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_0778300e-3c5b-4feb-b8bc-5172f7287332" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_47c9222a-9711-4b32-b53b-d2944af28fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_b1800966-cbbf-4eb7-b940-f29326b0dd3c" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_47c9222a-9711-4b32-b53b-d2944af28fb2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_856a819c-0535-43c9-a2d2-4f5429e49b39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8256e6f0-aff0-470a-9d76-3d809083c559" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_856a819c-0535-43c9-a2d2-4f5429e49b39" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_856a819c-0535-43c9-a2d2-4f5429e49b39_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_856a819c-0535-43c9-a2d2-4f5429e49b39" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_856a819c-0535-43c9-a2d2-4f5429e49b39_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_866f7f46-12c7-4a31-8d0a-8d1c88e6e1d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_856a819c-0535-43c9-a2d2-4f5429e49b39" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_866f7f46-12c7-4a31-8d0a-8d1c88e6e1d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_e4eb69cb-bdde-42f1-9398-baa6da5b2b0a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_866f7f46-12c7-4a31-8d0a-8d1c88e6e1d2" xlink:to="loc_us-gaap_CommercialPaperMember_e4eb69cb-bdde-42f1-9398-baa6da5b2b0a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8256e6f0-aff0-470a-9d76-3d809083c559" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7292d003-a845-452d-9491-bbcc98b83554" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c3a58b0a-279f-4bcc-9bc4-e2e13467d2d5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7292d003-a845-452d-9491-bbcc98b83554" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_36f9a0eb-422a-4c6d-be1f-62d675e9a01c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7292d003-a845-452d-9491-bbcc98b83554" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_36f9a0eb-422a-4c6d-be1f-62d675e9a01c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_0cc3e299-913b-460f-b8d5-35574fea3773" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7292d003-a845-452d-9491-bbcc98b83554" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_0cc3e299-913b-460f-b8d5-35574fea3773" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_ce518217-684e-432f-a44e-6ffb0af3ff75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7292d003-a845-452d-9491-bbcc98b83554" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_ce518217-684e-432f-a44e-6ffb0af3ff75" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsLineItems_0ca00778-50d1-498f-8b37-e605a9bbd2c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_b4cbc3b1-68f8-4a54-9819-1e04309af0bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_0ca00778-50d1-498f-8b37-e605a9bbd2c3" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_b4cbc3b1-68f8-4a54-9819-1e04309af0bb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_6eab7386-cf3a-41c7-9a0b-c150d57e0b02" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_0ca00778-50d1-498f-8b37-e605a9bbd2c3" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_6eab7386-cf3a-41c7-9a0b-c150d57e0b02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTable_58d0f54b-e2f4-4e57-ba2c-720f6cc0493d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_0ca00778-50d1-498f-8b37-e605a9bbd2c3" xlink:to="loc_us-gaap_OffsettingAssetsTable_58d0f54b-e2f4-4e57-ba2c-720f6cc0493d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingAssetsTable_58d0f54b-e2f4-4e57-ba2c-720f6cc0493d" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_96c7f1a6-ff4e-4b8a-b1fc-f5315f64a191" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyEuroSellUsDollarMember_111f38dd-f9e9-45bb-a2d0-c20968dfee41" xlink:href="lly-20230930.xsd#lly_BuyEuroSellUsDollarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:to="loc_lly_BuyEuroSellUsDollarMember_111f38dd-f9e9-45bb-a2d0-c20968dfee41" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyUsdSellEuroMember_8b3f060b-f208-4c69-adea-8159e34a5a61" xlink:href="lly-20230930.xsd#lly_BuyUsdSellEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:to="loc_lly_BuyUsdSellEuroMember_8b3f060b-f208-4c69-adea-8159e34a5a61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyUSDollarSellChineseYuanMember_cb7f6f2a-8647-4687-b363-3f3c3f245f3c" xlink:href="lly-20230930.xsd#lly_BuyUSDollarSellChineseYuanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:to="loc_lly_BuyUSDollarSellChineseYuanMember_cb7f6f2a-8647-4687-b363-3f3c3f245f3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyGBPSellUSDMember_df2e5132-4b3a-48c3-a1bf-829bb4154be7" xlink:href="lly-20230930.xsd#lly_BuyGBPSellUSDMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:to="loc_lly_BuyGBPSellUSDMember_df2e5132-4b3a-48c3-a1bf-829bb4154be7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_8f7fd1ee-424c-4913-970f-7eeb9341dec1" xlink:href="lly-20230930.xsd#lly_BuyUSdollarSellJapaneseYenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8507c1b7-84ff-4837-8f5e-fb4515214457" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_8f7fd1ee-424c-4913-970f-7eeb9341dec1" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofEffectofRiskManagementDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsScheduleofEffectofRiskManagementDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofEffectofRiskManagementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_FairValueHedgeAbstract_3e8b3f1c-71d7-4cbf-b77d-6cc47f282a45" xlink:href="lly-20230930.xsd#lly_FairValueHedgeAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_lly_FairValueHedgeAbstract_3e8b3f1c-71d7-4cbf-b77d-6cc47f282a45" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_8db92797-e642-4523-bbec-75cf723b641d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_3e8b3f1c-71d7-4cbf-b77d-6cc47f282a45" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_8db92797-e642-4523-bbec-75cf723b641d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_faed2a02-a6ab-40d2-b986-3ab9227c5099" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_3e8b3f1c-71d7-4cbf-b77d-6cc47f282a45" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_faed2a02-a6ab-40d2-b986-3ab9227c5099" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CashFlowHedgeAbstract_91c30893-4063-4bdc-beb6-2adb986cf69b" xlink:href="lly-20230930.xsd#lly_CashFlowHedgeAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_lly_CashFlowHedgeAbstract_91c30893-4063-4bdc-beb6-2adb986cf69b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_a0ab16d4-3cd6-4171-ae91-264472a48ad8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CashFlowHedgeAbstract_91c30893-4063-4bdc-beb6-2adb986cf69b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_a0ab16d4-3cd6-4171-ae91-264472a48ad8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_556d0665-240f-4b80-990b-fd03410eb4bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_556d0665-240f-4b80-990b-fd03410eb4bc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DerivativeInstrumentsGainLossRecognized_3d29370c-977b-4a5e-8bc0-15e439dbaa71" xlink:href="lly-20230930.xsd#lly_DerivativeInstrumentsGainLossRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_lly_DerivativeInstrumentsGainLossRecognized_3d29370c-977b-4a5e-8bc0-15e439dbaa71" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_f2b348f5-658a-4569-877c-5f671088031e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_f2b348f5-658a-4569-877c-5f671088031e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_2549813a-e0a5-44e8-b735-c478e3789d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_2549813a-e0a5-44e8-b735-c478e3789d3d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_dd24371f-e39c-4714-86f4-c32a199ca409" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_add9f4c0-eae5-4094-9cfe-c8c301e4d612" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_dd24371f-e39c-4714-86f4-c32a199ca409" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_dec65952-b7fc-4e00-9dee-9a1a64f22f48" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_dd24371f-e39c-4714-86f4-c32a199ca409" xlink:to="loc_us-gaap_HedgingDesignationAxis_dec65952-b7fc-4e00-9dee-9a1a64f22f48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_dec65952-b7fc-4e00-9dee-9a1a64f22f48_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_dec65952-b7fc-4e00-9dee-9a1a64f22f48" xlink:to="loc_us-gaap_HedgingDesignationDomain_dec65952-b7fc-4e00-9dee-9a1a64f22f48_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_9a80e4d0-10b4-443d-8767-0644c6c2208c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_dec65952-b7fc-4e00-9dee-9a1a64f22f48" xlink:to="loc_us-gaap_HedgingDesignationDomain_9a80e4d0-10b4-443d-8767-0644c6c2208c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_bd3db4ec-76a2-4d24-b209-cb8ad3818845" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_9a80e4d0-10b4-443d-8767-0644c6c2208c" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_bd3db4ec-76a2-4d24-b209-cb8ad3818845" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_dbb12116-18fa-4300-ba09-337db5ec10bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_9a80e4d0-10b4-443d-8767-0644c6c2208c" xlink:to="loc_us-gaap_NondesignatedMember_dbb12116-18fa-4300-ba09-337db5ec10bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_44826202-d299-4a68-9bbb-fdd543e747bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_dd24371f-e39c-4714-86f4-c32a199ca409" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_44826202-d299-4a68-9bbb-fdd543e747bd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_44826202-d299-4a68-9bbb-fdd543e747bd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_44826202-d299-4a68-9bbb-fdd543e747bd" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_44826202-d299-4a68-9bbb-fdd543e747bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_44826202-d299-4a68-9bbb-fdd543e747bd" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HedgedFixedRateDebtMember_beae8f20-4051-4950-bc53-2a1d15649f3a" xlink:href="lly-20230930.xsd#lly_HedgedFixedRateDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:to="loc_lly_HedgedFixedRateDebtMember_beae8f20-4051-4950-bc53-2a1d15649f3a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_db4bdb85-1cee-4caa-a840-e088766392ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:to="loc_us-gaap_InterestRateContractMember_db4bdb85-1cee-4caa-a840-e088766392ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_d6ed51c3-faa3-410f-a1e0-e61fc6052581" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_d6ed51c3-faa3-410f-a1e0-e61fc6052581" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_1405ae0c-d089-4362-829c-9e8d2528d8f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:to="loc_us-gaap_ForeignExchangeContractMember_1405ae0c-d089-4362-829c-9e8d2528d8f4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_8245b6d0-7028-47ba-a335-6d4728878758" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_8caf9abf-b1e6-4520-9059-0c78822e54ab" xlink:to="loc_us-gaap_InterestRateSwapMember_8245b6d0-7028-47ba-a335-6d4728878758" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_dff8fd0b-b40c-45d0-a527-6f5ca4c129fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_dff8fd0b-b40c-45d0-a527-6f5ca4c129fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_bd9636d6-de6b-46eb-938f-7cc01f522e75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_bd9636d6-de6b-46eb-938f-7cc01f522e75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_b1b9f192-7a10-4249-bbc0-ea6a0d43952e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_b1b9f192-7a10-4249-bbc0-ea6a0d43952e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_283713f4-afd6-4ba4-b4bf-cbc39bf6758d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_283713f4-afd6-4ba4-b4bf-cbc39bf6758d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_225db6f6-030a-4522-afba-72974514d476" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_225db6f6-030a-4522-afba-72974514d476" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e208ccd0-5b1f-4afb-8037-fca85f142117" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e208ccd0-5b1f-4afb-8037-fca85f142117" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_ea508591-b0c3-4bee-a249-198051510284" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_0ee6ec06-6d41-4623-987a-6d39d32ff2d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_0ee6ec06-6d41-4623-987a-6d39d32ff2d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_0ee6ec06-6d41-4623-987a-6d39d32ff2d8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_0ee6ec06-6d41-4623-987a-6d39d32ff2d8" xlink:to="loc_us-gaap_HedgingRelationshipDomain_0ee6ec06-6d41-4623-987a-6d39d32ff2d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_c06af3ed-30a0-477e-92d0-25a71c4469cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_0ee6ec06-6d41-4623-987a-6d39d32ff2d8" xlink:to="loc_us-gaap_HedgingRelationshipDomain_c06af3ed-30a0-477e-92d0-25a71c4469cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_9b608ea6-15ba-447d-8df8-29bd99dea0d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_c06af3ed-30a0-477e-92d0-25a71c4469cf" xlink:to="loc_us-gaap_FairValueHedgingMember_9b608ea6-15ba-447d-8df8-29bd99dea0d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_833b2f68-b03c-4dfc-8b45-3740a645035f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_c06af3ed-30a0-477e-92d0-25a71c4469cf" xlink:to="loc_us-gaap_CashFlowHedgingMember_833b2f68-b03c-4dfc-8b45-3740a645035f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_7e1ce350-27af-425c-8160-877d7c71c42f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_c06af3ed-30a0-477e-92d0-25a71c4469cf" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_7e1ce350-27af-425c-8160-877d7c71c42f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_35f16341-cc7b-492c-a6d6-47d2dfef3367" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_35f16341-cc7b-492c-a6d6-47d2dfef3367" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_35f16341-cc7b-492c-a6d6-47d2dfef3367_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_35f16341-cc7b-492c-a6d6-47d2dfef3367" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_35f16341-cc7b-492c-a6d6-47d2dfef3367_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_6ae62732-2685-41fd-9737-eb94038dc831" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_35f16341-cc7b-492c-a6d6-47d2dfef3367" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_6ae62732-2685-41fd-9737-eb94038dc831" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9178f93c-ac4b-4227-9e22-b445bc55c1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_6ae62732-2685-41fd-9737-eb94038dc831" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9178f93c-ac4b-4227-9e22-b445bc55c1d4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_337f7f9e-acd0-4bc7-a976-61cbbe70199e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_6ae62732-2685-41fd-9737-eb94038dc831" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_337f7f9e-acd0-4bc7-a976-61cbbe70199e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_f3273159-4da4-4b7f-8714-3dd25c359b57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_6ae62732-2685-41fd-9737-eb94038dc831" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_f3273159-4da4-4b7f-8714-3dd25c359b57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_d72ebea3-9f6c-42f3-89a5-55271fb497a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_d72ebea3-9f6c-42f3-89a5-55271fb497a6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_d72ebea3-9f6c-42f3-89a5-55271fb497a6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_d72ebea3-9f6c-42f3-89a5-55271fb497a6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_d72ebea3-9f6c-42f3-89a5-55271fb497a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_33e079f1-eac3-4b13-a445-8e15e3920076" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_d72ebea3-9f6c-42f3-89a5-55271fb497a6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_33e079f1-eac3-4b13-a445-8e15e3920076" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_0aac95f5-2de8-4c97-a4a5-a0f151fffeb2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_33e079f1-eac3-4b13-a445-8e15e3920076" xlink:to="loc_us-gaap_InterestRateContractMember_0aac95f5-2de8-4c97-a4a5-a0f151fffeb2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_0fb85b6d-b769-4292-a728-5cae99ba9933" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_33e079f1-eac3-4b13-a445-8e15e3920076" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_0fb85b6d-b769-4292-a728-5cae99ba9933" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_9e478091-4817-4471-aa4d-f674c2426df8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_33e079f1-eac3-4b13-a445-8e15e3920076" xlink:to="loc_us-gaap_ForeignExchangeContractMember_9e478091-4817-4471-aa4d-f674c2426df8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_fb12986f-1378-4d17-9544-97ab88353a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:to="loc_us-gaap_HedgingDesignationAxis_fb12986f-1378-4d17-9544-97ab88353a3c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_fb12986f-1378-4d17-9544-97ab88353a3c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_fb12986f-1378-4d17-9544-97ab88353a3c" xlink:to="loc_us-gaap_HedgingDesignationDomain_fb12986f-1378-4d17-9544-97ab88353a3c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_51da23ae-0162-41fb-b4b1-c02ef3cf2abe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_fb12986f-1378-4d17-9544-97ab88353a3c" xlink:to="loc_us-gaap_HedgingDesignationDomain_51da23ae-0162-41fb-b4b1-c02ef3cf2abe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_9ff4b097-1cca-45d1-bfa9-0ecc88ad2f40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_51da23ae-0162-41fb-b4b1-c02ef3cf2abe" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_9ff4b097-1cca-45d1-bfa9-0ecc88ad2f40" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_aca38a0a-4b21-4e84-8313-daddb80e6c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_51da23ae-0162-41fb-b4b1-c02ef3cf2abe" xlink:to="loc_us-gaap_NondesignatedMember_aca38a0a-4b21-4e84-8313-daddb80e6c6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5f90b6eb-a33c-4722-a487-f0b95883537c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_775361c0-bb4b-4f29-adc3-6404ece8e4bc" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5f90b6eb-a33c-4722-a487-f0b95883537c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5f90b6eb-a33c-4722-a487-f0b95883537c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5f90b6eb-a33c-4722-a487-f0b95883537c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5f90b6eb-a33c-4722-a487-f0b95883537c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7f2d12a1-e93e-4889-aa68-0264d560485a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5f90b6eb-a33c-4722-a487-f0b95883537c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7f2d12a1-e93e-4889-aa68-0264d560485a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_78c7285d-5427-493a-82af-aae98ed504cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7f2d12a1-e93e-4889-aa68-0264d560485a" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_78c7285d-5427-493a-82af-aae98ed504cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_1daac642-d157-4e81-8c6b-7d9cbcf3ed08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7f2d12a1-e93e-4889-aa68-0264d560485a" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_1daac642-d157-4e81-8c6b-7d9cbcf3ed08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_75f4e0a0-42c7-4b5e-a37f-2b3393b5628c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7f2d12a1-e93e-4889-aa68-0264d560485a" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_75f4e0a0-42c7-4b5e-a37f-2b3393b5628c" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_32ad08c0-8d58-4c56-8a3a-46a1e0a1b6e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_32ad08c0-8d58-4c56-8a3a-46a1e0a1b6e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_f9eaf6c6-c065-4f2d-a7d3-11c5f09c6d93" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_f9eaf6c6-c065-4f2d-a7d3-11c5f09c6d93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_b399605f-d6b3-409c-9c72-47e46ad1e8e9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_b399605f-d6b3-409c-9c72-47e46ad1e8e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_9e1a4dcb-6ff7-4988-8c95-fd1dbc2e1368" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_9e1a4dcb-6ff7-4988-8c95-fd1dbc2e1368" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_2ad97401-5e40-447e-a272-3edb43842960" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_2ad97401-5e40-447e-a272-3edb43842960" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ebe51c17-73a5-4e8b-849d-9f2afea41a74" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_ebe51c17-73a5-4e8b-849d-9f2afea41a74" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_e1477680-37e3-440c-aa82-a4e2356dbb17" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_26c4a63e-a617-4a33-b59a-d6fa123e655e" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_e1477680-37e3-440c-aa82-a4e2356dbb17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_77165c57-6e42-4521-ad82-58b121b80ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_e1477680-37e3-440c-aa82-a4e2356dbb17" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_77165c57-6e42-4521-ad82-58b121b80ce8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_77165c57-6e42-4521-ad82-58b121b80ce8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_77165c57-6e42-4521-ad82-58b121b80ce8" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_77165c57-6e42-4521-ad82-58b121b80ce8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_e8981f99-d485-46f8-ba4b-fdc15c7a3756" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_77165c57-6e42-4521-ad82-58b121b80ce8" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_e8981f99-d485-46f8-ba4b-fdc15c7a3756" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_cccd1934-b385-4ab1-9296-f0f663e4bf94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_e8981f99-d485-46f8-ba4b-fdc15c7a3756" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_cccd1934-b385-4ab1-9296-f0f663e4bf94" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_c887c1e1-98bc-444c-82e6-57b19bc06d57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_e8981f99-d485-46f8-ba4b-fdc15c7a3756" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_c887c1e1-98bc-444c-82e6-57b19bc06d57" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#ContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_LossContingencyNumberOfPatents_8fe484f8-1482-45e7-a96e-0067b38b64f8" xlink:href="lly-20230930.xsd#lly_LossContingencyNumberOfPatents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:to="loc_lly_LossContingencyNumberOfPatents_8fe484f8-1482-45e7-a96e-0067b38b64f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_LossContingencyNumberOfSitesJointlyAndSeverallyLiableForCleanup_eeef7447-1caa-418c-bbe9-5a5266a30e94" xlink:href="lly-20230930.xsd#lly_LossContingencyNumberOfSitesJointlyAndSeverallyLiableForCleanup"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:to="loc_lly_LossContingencyNumberOfSitesJointlyAndSeverallyLiableForCleanup_eeef7447-1caa-418c-bbe9-5a5266a30e94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_574ec941-7182-488e-9905-0c43d48410c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyDamagesAwardedValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_574ec941-7182-488e-9905-0c43d48410c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_94e754e4-b70b-45de-b8ee-10f172c2ef43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyPendingClaimsNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_94e754e4-b70b-45de-b8ee-10f172c2ef43" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_9ef7550d-28a2-4418-9c84-f8311a428dbf" xlink:to="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:to="loc_srt_LitigationCaseAxis_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f" xlink:to="loc_srt_LitigationCaseTypeDomain_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0682ac8b-e87f-4bc4-bd01-32b5ea4f0ae8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_3daf22cd-bdd2-49b6-ad5b-eea149d37e5f" xlink:to="loc_srt_LitigationCaseTypeDomain_0682ac8b-e87f-4bc4-bd01-32b5ea4f0ae8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmgalityPatentLitigationMember_7038423b-6ba6-4874-9376-0b7717ce8129" xlink:href="lly-20230930.xsd#lly_EmgalityPatentLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0682ac8b-e87f-4bc4-bd01-32b5ea4f0ae8" xlink:to="loc_lly_EmgalityPatentLitigationMember_7038423b-6ba6-4874-9376-0b7717ce8129" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmployeeLitigationJuly2018RulingMember_3fdd5a22-ff5b-4dff-9006-823bdee3677f" xlink:href="lly-20230930.xsd#lly_EmployeeLitigationJuly2018RulingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0682ac8b-e87f-4bc4-bd01-32b5ea4f0ae8" xlink:to="loc_lly_EmployeeLitigationJuly2018RulingMember_3fdd5a22-ff5b-4dff-9006-823bdee3677f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmployeeLitigationJuly2019RulingMember_976ef663-da9c-48ab-8703-a21335f1ae7f" xlink:href="lly-20230930.xsd#lly_EmployeeLitigationJuly2019RulingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0682ac8b-e87f-4bc4-bd01-32b5ea4f0ae8" xlink:to="loc_lly_EmployeeLitigationJuly2019RulingMember_976ef663-da9c-48ab-8703-a21335f1ae7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_8247234a-6223-49e9-b746-f8d479117470" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:to="loc_srt_ProductOrServiceAxis_8247234a-6223-49e9-b746-f8d479117470" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_8247234a-6223-49e9-b746-f8d479117470_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_8247234a-6223-49e9-b746-f8d479117470" xlink:to="loc_srt_ProductsAndServicesDomain_8247234a-6223-49e9-b746-f8d479117470_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6b44c20c-7bd8-4ebb-91d1-637f2bb82fad" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_8247234a-6223-49e9-b746-f8d479117470" xlink:to="loc_srt_ProductsAndServicesDomain_6b44c20c-7bd8-4ebb-91d1-637f2bb82fad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HumalogHumulinAndForteoMember_4ea0254b-b683-4500-87be-efe66b2b5aa0" xlink:href="lly-20230930.xsd#lly_HumalogHumulinAndForteoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6b44c20c-7bd8-4ebb-91d1-637f2bb82fad" xlink:to="loc_lly_HumalogHumulinAndForteoMember_4ea0254b-b683-4500-87be-efe66b2b5aa0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae" xlink:to="loc_us-gaap_LossContingencyNatureDomain_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_57078a09-0306-4b83-8832-3fe8dfe6b28d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_5c0cb35b-5c58-4be5-82d9-facc0b1d1bae" xlink:to="loc_us-gaap_LossContingencyNatureDomain_57078a09-0306-4b83-8832-3fe8dfe6b28d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnfavorableRegulatoryActionMember_329e5c54-0991-42a4-86a3-2986720f3134" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_UnfavorableRegulatoryActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_57078a09-0306-4b83-8832-3fe8dfe6b28d" xlink:to="loc_us-gaap_UnfavorableRegulatoryActionMember_329e5c54-0991-42a4-86a3-2986720f3134" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_1521b53f-efe8-4e53-93f5-6f9edc014b28" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_ae9e3541-c011-45db-b704-4f555bbe98f8" xlink:to="loc_srt_StatementGeographicalAxis_1521b53f-efe8-4e53-93f5-6f9edc014b28" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_1521b53f-efe8-4e53-93f5-6f9edc014b28_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_1521b53f-efe8-4e53-93f5-6f9edc014b28" xlink:to="loc_srt_SegmentGeographicalDomain_1521b53f-efe8-4e53-93f5-6f9edc014b28_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_1754f2b9-d506-4c23-9c1f-c0d08bf58931" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_1521b53f-efe8-4e53-93f5-6f9edc014b28" xlink:to="loc_srt_SegmentGeographicalDomain_1754f2b9-d506-4c23-9c1f-c0d08bf58931" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_BR_b8da1851-3b5d-4dc2-b44a-7151be68baec" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_BR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_1754f2b9-d506-4c23-9c1f-c0d08bf58931" xlink:to="loc_country_BR_b8da1851-3b5d-4dc2-b44a-7151be68baec" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossAOCIDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#OtherComprehensiveIncomeLossAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_1e2d167b-7617-46ec-bd10-e4615fc1c138" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_1e2d167b-7617-46ec-bd10-e4615fc1c138" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_35d838a4-2bd2-4161-9deb-a6a08014267f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_35d838a4-2bd2-4161-9deb-a6a08014267f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_bf4f99ad-08cf-41f2-a551-79d1f5b599ba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_bf4f99ad-08cf-41f2-a551-79d1f5b599ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_fdf7d57b-99fa-4e44-a2e3-95884467726d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_fdf7d57b-99fa-4e44-a2e3-95884467726d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d7c06005-fb27-4eab-b4e4-846d0c5e9748" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_db521420-202c-4e0c-9235-7845edfbbfbd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d7c06005-fb27-4eab-b4e4-846d0c5e9748" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_ddd01107-40bc-45c9-8114-4e97cb3e5a03" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_aff3aa53-6432-4de9-bf31-33dc93832a56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_1e2d167b-7617-46ec-bd10-e4615fc1c138" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_aff3aa53-6432-4de9-bf31-33dc93832a56" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_23b7db43-69c6-4496-8769-ed071fc1a521" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_aff3aa53-6432-4de9-bf31-33dc93832a56" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_23b7db43-69c6-4496-8769-ed071fc1a521" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_23b7db43-69c6-4496-8769-ed071fc1a521_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_23b7db43-69c6-4496-8769-ed071fc1a521" xlink:to="loc_us-gaap_EquityComponentDomain_23b7db43-69c6-4496-8769-ed071fc1a521_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3837d65f-0772-4d0a-9d5f-d96fa3d6e677" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_23b7db43-69c6-4496-8769-ed071fc1a521" xlink:to="loc_us-gaap_EquityComponentDomain_3837d65f-0772-4d0a-9d5f-d96fa3d6e677" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3837d65f-0772-4d0a-9d5f-d96fa3d6e677" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_7beb7156-683d-4e03-add5-cf1d91ffd541" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_7beb7156-683d-4e03-add5-cf1d91ffd541" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_03233cfd-72ac-4396-87d8-593b77f7fac7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_03233cfd-72ac-4396-87d8-593b77f7fac7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6ec57d08-e924-4757-b8fb-96a95329fe22" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6ec57d08-e924-4757-b8fb-96a95329fe22" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_c273580a-3bea-4c15-ba0b-ef89234386cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_c936e87d-baf2-4ed4-b076-a682baaf9c95" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_c273580a-3bea-4c15-ba0b-ef89234386cf" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#OtherComprehensiveIncomeLossTaxEffectDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5ad8431c-849e-401c-b127-50713f05419b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_4f807812-3e22-408e-b16f-ca66fa3dac42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5ad8431c-849e-401c-b127-50713f05419b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_4f807812-3e22-408e-b16f-ca66fa3dac42" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4f2e33ee-40bf-4890-a83e-40307cc0009e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5ad8431c-849e-401c-b127-50713f05419b" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4f2e33ee-40bf-4890-a83e-40307cc0009e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_04e62bfb-d663-4b51-9dd9-b4756efa32e7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4f2e33ee-40bf-4890-a83e-40307cc0009e" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_04e62bfb-d663-4b51-9dd9-b4756efa32e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_04e62bfb-d663-4b51-9dd9-b4756efa32e7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_04e62bfb-d663-4b51-9dd9-b4756efa32e7" xlink:to="loc_us-gaap_EquityComponentDomain_04e62bfb-d663-4b51-9dd9-b4756efa32e7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_04e62bfb-d663-4b51-9dd9-b4756efa32e7" xlink:to="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_b63e029c-10da-41d1-a5ce-2e37bb216eeb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_b63e029c-10da-41d1-a5ce-2e37bb216eeb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_87aa63ad-f3cd-4417-9098-712054bcd7c6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_87aa63ad-f3cd-4417-9098-712054bcd7c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_0562ff0a-0f57-4a27-bc5d-1b0d4cac55fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_0562ff0a-0f57-4a27-bc5d-1b0d4cac55fe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_5f605e4e-7be5-4557-ba17-3796c8dcbe18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ab6f0c6f-01df-4b40-94cf-080d3e648aa5" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_5f605e4e-7be5-4557-ba17-3796c8dcbe18" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="simple" xlink:href="lly-20230930.xsd#OtherComprehensiveIncomeLossReclassificationDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_6d3abcc9-e3b8-403a-972b-08bb44c1abe6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_6d3abcc9-e3b8-403a-972b-08bb44c1abe6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fc32a841-ed1b-4173-9ef9-90d23466241c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fc32a841-ed1b-4173-9ef9-90d23466241c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4bf87358-2f74-47cf-a8ee-07bed9eb6f05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4bf87358-2f74-47cf-a8ee-07bed9eb6f05" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_405f2fcd-72a9-471e-b074-7bc197093ad9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:to="loc_us-gaap_ProfitLoss_405f2fcd-72a9-471e-b074-7bc197093ad9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_2d3c69a1-d34a-4a57-89c2-fb0ee326121d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6a639d1d-61cc-4202-942b-3234b4722507" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_2d3c69a1-d34a-4a57-89c2-fb0ee326121d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_8c003550-189a-496c-b0e8-a9eeb2a9c3b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_2d3c69a1-d34a-4a57-89c2-fb0ee326121d" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_8c003550-189a-496c-b0e8-a9eeb2a9c3b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_8c003550-189a-496c-b0e8-a9eeb2a9c3b3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8c003550-189a-496c-b0e8-a9eeb2a9c3b3" xlink:to="loc_us-gaap_EquityComponentDomain_8c003550-189a-496c-b0e8-a9eeb2a9c3b3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_770148ef-c121-4f3d-8700-29ff0cf884b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8c003550-189a-496c-b0e8-a9eeb2a9c3b3" xlink:to="loc_us-gaap_EquityComponentDomain_770148ef-c121-4f3d-8700-29ff0cf884b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_734fa9af-44c5-413d-9ff5-23746b8338cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_770148ef-c121-4f3d-8700-29ff0cf884b2" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_734fa9af-44c5-413d-9ff5-23746b8338cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_b8bb8699-fc00-4ba6-b988-9255b9d83623" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_734fa9af-44c5-413d-9ff5-23746b8338cf" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_b8bb8699-fc00-4ba6-b988-9255b9d83623" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_778e9e4f-7fae-46c5-8276-a6a7fd06e6f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_734fa9af-44c5-413d-9ff5-23746b8338cf" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_778e9e4f-7fae-46c5-8276-a6a7fd06e6f5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_ef4c7edd-cc59-4b22-8d49-2724f52cc805" xlink:href="lly-20230930.xsd#lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_770148ef-c121-4f3d-8700-29ff0cf884b2" xlink:to="loc_lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_ef4c7edd-cc59-4b22-8d49-2724f52cc805" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_2d3c69a1-d34a-4a57-89c2-fb0ee326121d" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_d7b6dc3e-4544-4441-84d3-c134495a7003" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_fc6315db-cb50-48d1-aa2c-0c22fa5bcdbd" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_d7b6dc3e-4544-4441-84d3-c134495a7003" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_6e066813-b374-4332-b5c7-7ccb7004b860" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_d7b6dc3e-4544-4441-84d3-c134495a7003" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_6e066813-b374-4332-b5c7-7ccb7004b860" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
