<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.lilly.com/role/Acquisitions" xlink:href="lly-20200331.xsd#Acquisitions" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAssetAcquisitionsDetails" xlink:href="lly-20200331.xsd#AcquisitionsAssetAcquisitionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:href="lly-20200331.xsd#AcquisitionsAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:href="lly-20200331.xsd#AcquisitionsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsPolicies" xlink:href="lly-20200331.xsd#AcquisitionsPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsTables" xlink:href="lly-20200331.xsd#AcquisitionsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:href="lly-20200331.xsd#AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:href="lly-20200331.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:href="lly-20200331.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BasisOfPresentation" xlink:href="lly-20200331.xsd#BasisOfPresentation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:href="lly-20200331.xsd#CollaborationsAndOtherArrangements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:href="lly-20200331.xsd#CollaborationsAndOtherArrangementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:href="lly-20200331.xsd#CollaborationsAndOtherArrangementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheets" xlink:href="lly-20200331.xsd#ConsolidatedCondensedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheetsParenthetical" xlink:href="lly-20200331.xsd#ConsolidatedCondensedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlowsUnaudited" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlowsUnauditedParenthetical" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfCashFlowsUnauditedParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfComprehensiveIncomeLossUnaudited" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfEquityUnaudited" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfEquityUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfEquityUnauditedParenthetical" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfEquityUnauditedParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfOperationsUnaudited" xlink:href="lly-20200331.xsd#ConsolidatedCondensedStatementsOfOperationsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Contingencies" xlink:href="lly-20200331.xsd#Contingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:href="lly-20200331.xsd#ContingenciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CoverPage" xlink:href="lly-20200331.xsd#CoverPage" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperations" xlink:href="lly-20200331.xsd#DiscontinuedOperations" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperationsNarrativeDetails" xlink:href="lly-20200331.xsd#DiscontinuedOperationsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstruments" xlink:href="lly-20200331.xsd#FinancialInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsContractualMaturitiesDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsContractualMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsEffectOfRiskManagementInstrumentsDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsEffectOfRiskManagementInstrumentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsFairValueOfFinancialInstrumentsDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsFairValueOfFinancialInstrumentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:href="lly-20200331.xsd#FinancialInstrumentsPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsRealizedGainsAndLossesDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsRealizedGainsAndLossesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsRiskManagementInstrumentsDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsRiskManagementInstrumentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:href="lly-20200331.xsd#FinancialInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsUnrealizedGainsAndLossesDetails" xlink:href="lly-20200331.xsd#FinancialInstrumentsUnrealizedGainsAndLossesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxes" xlink:href="lly-20200331.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesDetails" xlink:href="lly-20200331.xsd#IncomeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:href="lly-20200331.xsd#OtherComprehensiveIncomeLoss" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossAociDetails" xlink:href="lly-20200331.xsd#OtherComprehensiveIncomeLossAociDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:href="lly-20200331.xsd#OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:href="lly-20200331.xsd#OtherComprehensiveIncomeLossTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:href="lly-20200331.xsd#OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OthernetIncomeExpense" xlink:href="lly-20200331.xsd#OthernetIncomeExpense" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OthernetIncomeExpenseDetails" xlink:href="lly-20200331.xsd#OthernetIncomeExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OthernetIncomeExpenseTables" xlink:href="lly-20200331.xsd#OthernetIncomeExpenseTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefits" xlink:href="lly-20200331.xsd#RetirementBenefits" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsComponentsOfNetPeriodicBenefitCostDetails" xlink:href="lly-20200331.xsd#RetirementBenefitsComponentsOfNetPeriodicBenefitCostDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsNarrativeDetails" xlink:href="lly-20200331.xsd#RetirementBenefitsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsTables" xlink:href="lly-20200331.xsd#RetirementBenefitsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Revenue" xlink:href="lly-20200331.xsd#Revenue" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueContractLiabilitiesDetails" xlink:href="lly-20200331.xsd#RevenueContractLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:href="lly-20200331.xsd#RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByProductDetails" xlink:href="lly-20200331.xsd#RevenueDisaggregationOfRevenueByProductDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueNarrativeDetails" xlink:href="lly-20200331.xsd#RevenueNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueSummaryOfRevenueRecognizedDetails" xlink:href="lly-20200331.xsd#RevenueSummaryOfRevenueRecognizedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueTables" xlink:href="lly-20200331.xsd#RevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.lilly.com/role/Acquisitions" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_3CA37E5FDCE6B8F8C475CD17BC65EE9F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock" xlink:label="loc_us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock_664F4308F298641BAAB0CD17BC65D79C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_3CA37E5FDCE6B8F8C475CD17BC65EE9F" xlink:to="loc_us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock_664F4308F298641BAAB0CD17BC65D79C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsAssetAcquisitionsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_6B43DD43CA91EAA46A6BCD17BC3FFAE8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_12D22854DE0F2995C221CD17BC3FD4E9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_6B43DD43CA91EAA46A6BCD17BC3FFAE8" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_12D22854DE0F2995C221CD17BC3FD4E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_C7899C07BCCDD54639AECD17BC40D3C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_12D22854DE0F2995C221CD17BC3FD4E9" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_C7899C07BCCDD54639AECD17BC40D3C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C5265A9E837CCFF5C212CD17BC409122" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_C7899C07BCCDD54639AECD17BC40D3C6" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C5265A9E837CCFF5C212CD17BC409122" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SitryxTherapeuticsLimitedMember" xlink:label="loc_lly_SitryxTherapeuticsLimitedMember_2CCFFC426371DAE7B628CD17BC40FF57" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C5265A9E837CCFF5C212CD17BC409122" xlink:to="loc_lly_SitryxTherapeuticsLimitedMember_2CCFFC426371DAE7B628CD17BC40FF57" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ACImmuneSAMember" xlink:label="loc_lly_ACImmuneSAMember_7BC4635E61A5456D6894CD17BC40B972" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C5265A9E837CCFF5C212CD17BC409122" xlink:to="loc_lly_ACImmuneSAMember_7BC4635E61A5456D6894CD17BC40B972" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ImmuNextInc.Member" xlink:label="loc_lly_ImmuNextInc.Member_6C8F083C7D58D1768AE5CD17BC41CD09" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C5265A9E837CCFF5C212CD17BC409122" xlink:to="loc_lly_ImmuNextInc.Member_6C8F083C7D58D1768AE5CD17BC41CD09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_50CE0D072C94D4A004F7CD17BC41F889" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_12D22854DE0F2995C221CD17BC3FD4E9" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_50CE0D072C94D4A004F7CD17BC41F889" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_3813D3327E121926A009CD17BC41D4CD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_50CE0D072C94D4A004F7CD17BC41F889" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_3813D3327E121926A009CD17BC41D4CD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsAssetsAcquiredAndLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_7C954CD62BABC1B39E7CCD17BC461501" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_7C954CD62BABC1B39E7CCD17BC461501" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_0200654BE259006C8BA2CD17BC4756FB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:to="loc_srt_ProductOrServiceAxis_0200654BE259006C8BA2CD17BC4756FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_48E100B39E7A4AAEF38FCD17BC474FB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_0200654BE259006C8BA2CD17BC4756FB" xlink:to="loc_srt_ProductsAndServicesDomain_48E100B39E7A4AAEF38FCD17BC474FB6" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SelpercatinibLOXO292Member" xlink:label="loc_lly_SelpercatinibLOXO292Member_E56AA17CABF521C8DBD3CD17BC475E1E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_48E100B39E7A4AAEF38FCD17BC474FB6" xlink:to="loc_lly_SelpercatinibLOXO292Member_E56AA17CABF521C8DBD3CD17BC475E1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_411AD63AF27136CFBD17CD17BC48713A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_411AD63AF27136CFBD17CD17BC48713A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FA99C05D9A316123E6A5CD17BC488986" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_411AD63AF27136CFBD17CD17BC48713A" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FA99C05D9A316123E6A5CD17BC488986" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractBasedIntangibleAssetsMember" xlink:label="loc_us-gaap_ContractBasedIntangibleAssetsMember_1078B7B9CDD0F4F99916CD17BC4830A9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FA99C05D9A316123E6A5CD17BC488986" xlink:to="loc_us-gaap_ContractBasedIntangibleAssetsMember_1078B7B9CDD0F4F99916CD17BC4830A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_B35C073E04701B91A19DCD17BC487BC5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_B35C073E04701B91A19DCD17BC487BC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5939AC4FDDD621AF4ABDCD17BC488265" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_B35C073E04701B91A19DCD17BC487BC5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5939AC4FDDD621AF4ABDCD17BC488265" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DermiraInc.Member" xlink:label="loc_lly_DermiraInc.Member_26D4F8E64C559476B668CD17BC497650" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5939AC4FDDD621AF4ABDCD17BC488265" xlink:to="loc_lly_DermiraInc.Member_26D4F8E64C559476B668CD17BC497650" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_F10827FD3580461AAFADCD17BC4944D4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5939AC4FDDD621AF4ABDCD17BC488265" xlink:to="loc_lly_LoxoOncologyInc.Member_F10827FD3580461AAFADCD17BC4944D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_147424ED02A577258E01CD17BC4677FA" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment_F4B1B3533EDD4AC5F464CD17BC49B4BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment_F4B1B3533EDD4AC5F464CD17BC49B4BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_CE118CB2F6EA7B295C40CD17BC4A9889" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_CE118CB2F6EA7B295C40CD17BC4A9889" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_B3C631D05AA64A50218FCD17BC4AF5FF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_B3C631D05AA64A50218FCD17BC4AF5FF" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet_7A2866A3BCFEF4D986AECD17BC4A4856" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet_7A2866A3BCFEF4D986AECD17BC4A4856" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_16487B49F2BE0C8EDF98CD17BC4AD111" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_16487B49F2BE0C8EDF98CD17BC4AD111" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_D70249F9FA00E681830DCD17BC4A50ED" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_Goodwill_D70249F9FA00E681830DCD17BC4A50ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_F46D809946C030E9658ACD17BC4AE9F0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_F46D809946C030E9658ACD17BC4AE9F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_F23479B3118B52FEF6D8CD17BC4B2816" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2BE8689659C37837B99FCD17BC4942B5" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_F23479B3118B52FEF6D8CD17BC4B2816" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_C54BF1DEA71C0D449B86CD17BC4FFEDE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3B01722893C035DB8D9CCD17BC4F0579" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_C54BF1DEA71C0D449B86CD17BC4FFEDE" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3B01722893C035DB8D9CCD17BC4F0579" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_17A6E4E243AF11489B30CD17BC504AF8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3B01722893C035DB8D9CCD17BC4F0579" xlink:to="loc_srt_CounterpartyNameAxis_17A6E4E243AF11489B30CD17BC504AF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8CC1ED92598EE114553DCD17BC504E8B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_17A6E4E243AF11489B30CD17BC504AF8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8CC1ED92598EE114553DCD17BC504E8B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AbCelleraBiologicsInc.Member" xlink:label="loc_lly_AbCelleraBiologicsInc.Member_FDE7956DC652E3BDD5A2CD17BC509B34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8CC1ED92598EE114553DCD17BC504E8B" xlink:to="loc_lly_AbCelleraBiologicsInc.Member_FDE7956DC652E3BDD5A2CD17BC509B34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_27F1B1E3C0126A29D8F1CD17BC51E668" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3B01722893C035DB8D9CCD17BC4F0579" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_27F1B1E3C0126A29D8F1CD17BC51E668" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_012DFA010E69C5521B62CD17BC51425D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_27F1B1E3C0126A29D8F1CD17BC51E668" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_012DFA010E69C5521B62CD17BC51425D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DermiraInc.Member" xlink:label="loc_lly_DermiraInc.Member_BEBBAADBFB96E24417D6CD17BC51A6FE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_012DFA010E69C5521B62CD17BC51425D" xlink:to="loc_lly_DermiraInc.Member_BEBBAADBFB96E24417D6CD17BC51A6FE" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_13B44B2A7A8AAB5EC6C9CD17BC511600" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_012DFA010E69C5521B62CD17BC51425D" xlink:to="loc_lly_LoxoOncologyInc.Member_13B44B2A7A8AAB5EC6C9CD17BC511600" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3B01722893C035DB8D9CCD17BC4F0579" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_2FDDCF60EABBC53E81B8CD17BC51B08F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/netLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_2FDDCF60EABBC53E81B8CD17BC51B08F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_4D67BD86A46D01F995D4CD17BC52A371" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_4D67BD86A46D01F995D4CD17BC52A371" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_DD98F702EE26594B53DFCD17BC521446" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_us-gaap_Goodwill_DD98F702EE26594B53DFCD17BC521446" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_9EB8F5C5B85FE2D53C0ECD17BC52FF8A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_9EB8F5C5B85FE2D53C0ECD17BC52FF8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_C54A24637ADD7913E4A6CD17BC521CCC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_C54A24637ADD7913E4A6CD17BC521CCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_F24AC3C1C4072001924DCD17BC528C16" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_F24AC3C1C4072001924DCD17BC528C16" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ResearchAndDevelopmentArrangementUpfrontFee" xlink:label="loc_lly_ResearchAndDevelopmentArrangementUpfrontFee_B243BC5E93AEAD9CA658CD17BC535EBD" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_35F60377AA9492309AA6CD17BC5169CA" xlink:to="loc_lly_ResearchAndDevelopmentArrangementUpfrontFee_B243BC5E93AEAD9CA658CD17BC535EBD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_49EEB248C97642104317CD17BC639035" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_B2C5F8647904D39353C2CD17BC6356D4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_49EEB248C97642104317CD17BC639035" xlink:to="loc_us-gaap_BusinessCombinationsPolicy_B2C5F8647904D39353C2CD17BC6356D4" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_DA8FBEC41AE7105136F5CD17BC600CCC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_FAA1CC1C60607C8C46C0CD17BC600C34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_DA8FBEC41AE7105136F5CD17BC600CCC" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_FAA1CC1C60607C8C46C0CD17BC600C34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_2CEE9BE3D84C71A04750CD17BC6075AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_DA8FBEC41AE7105136F5CD17BC600CCC" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_2CEE9BE3D84C71A04750CD17BC6075AD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_2096B74DE321038CF86BCD17BB84B5DE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock_E32D2E56BA88FBDE9176CD17BB8523C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_2096B74DE321038CF86BCD17BB84B5DE" xlink:to="loc_us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock_E32D2E56BA88FBDE9176CD17BB8523C5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_722B7AA91E5998A55E8ECD17BB78AF28" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD2DBC63EE9BBC14BAD4CD17BB794E6F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_722B7AA91E5998A55E8ECD17BB78AF28" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD2DBC63EE9BBC14BAD4CD17BB794E6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_98BE20034B427C17B5C0CD17BB7949EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD2DBC63EE9BBC14BAD4CD17BB794E6F" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_98BE20034B427C17B5C0CD17BB7949EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D872053F05A18E5F839BCD17BB79F4ED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_98BE20034B427C17B5C0CD17BB7949EC" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D872053F05A18E5F839BCD17BB79F4ED" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_0C095869A874BCDCA325CD17BB7A4FE2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_D872053F05A18E5F839BCD17BB79F4ED" xlink:to="loc_lly_LoxoOncologyInc.Member_0C095869A874BCDCA325CD17BB7A4FE2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_2614B04D490DEA2FC4E0CD17BB7A2579" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_DD2DBC63EE9BBC14BAD4CD17BB794E6F" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_2614B04D490DEA2FC4E0CD17BB7A2579" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_F7C6F04E30FE0FB90348CD17BB7AC898" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2614B04D490DEA2FC4E0CD17BB7A2579" xlink:to="loc_us-gaap_SeveranceCosts1_F7C6F04E30FE0FB90348CD17BB7AC898" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetImpairmentCharges" xlink:label="loc_us-gaap_AssetImpairmentCharges_5F3A9813347B0D90DB55CD17BB7A6413" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2614B04D490DEA2FC4E0CD17BB7A2579" xlink:to="loc_us-gaap_AssetImpairmentCharges_5F3A9813347B0D90DB55CD17BB7A6413" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_CDF288A312F4B476EA68CD17BB7A8E8B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_2614B04D490DEA2FC4E0CD17BB7A2579" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_CDF288A312F4B476EA68CD17BB7A8E8B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_C2EBAC4F246789F33A44CD17BB7D8E22" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_16086B4C901DC6BF6662CD17BB7D0ECF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_C2EBAC4F246789F33A44CD17BB7D8E22" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_16086B4C901DC6BF6662CD17BB7D0ECF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/BasisOfPresentation" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6D7F21E3771BA7ADCBF8CD17BCA4D86A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_B354BA362E9BA443F1B7CD17BCA43D33" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6D7F21E3771BA7ADCBF8CD17BCA4D86A" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_B354BA362E9BA443F1B7CD17BCA43D33" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_DE1E3ACFB142909FB337CD17BC3DE8D1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_6A4F40C45FF698EDB50ACD17BC3D9941" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_DE1E3ACFB142909FB337CD17BC3DE8D1" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_6A4F40C45FF698EDB50ACD17BC3D9941" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_37DF0F932B2D54A5F439CD17BC30EED3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_37DF0F932B2D54A5F439CD17BC30EED3" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_B37270E570E09D2C61ABCD17BC308941" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_B37270E570E09D2C61ABCD17BC308941" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_920047E201FDD2024EECCD17BC304F01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_B37270E570E09D2C61ABCD17BC308941" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_920047E201FDD2024EECCD17BC304F01" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DermiraInc.Member" xlink:label="loc_lly_DermiraInc.Member_9084ED91BCD4EEA624ACCD17BC3142A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_920047E201FDD2024EECCD17BC304F01" xlink:to="loc_lly_DermiraInc.Member_9084ED91BCD4EEA624ACCD17BC3142A3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_E57DBFD8AEC301CDCEA3CD17BC31DA33" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_dei_LegalEntityAxis_E57DBFD8AEC301CDCEA3CD17BC31DA33" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_691F407E5D44B1517E65CD17BC3102B9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_E57DBFD8AEC301CDCEA3CD17BC31DA33" xlink:to="loc_dei_EntityDomain_691F407E5D44B1517E65CD17BC3102B9" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_RocheMember" xlink:label="loc_lly_RocheMember_E80F8E20AF787FEFEE4BCD17BC311773" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_691F407E5D44B1517E65CD17BC3102B9" xlink:to="loc_lly_RocheMember_E80F8E20AF787FEFEE4BCD17BC311773" xlink:type="arc" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_691F407E5D44B1517E65CD17BC3102B9" xlink:to="loc_lly_DermiraInc.Member_9084ED91BCD4EEA624ACCD17BC3142A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_09EC8BBF6F2A817B49B8CD17BC32C546" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_us-gaap_TypeOfArrangementAxis_09EC8BBF6F2A817B49B8CD17BC32C546" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_09EC8BBF6F2A817B49B8CD17BC32C546" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_AE6586E5F67CBDAA41FECD17BC325FFF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_AE6586E5F67CBDAA41FECD17BC325FFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_B2746D8C59CED2B67502CD17BC33307B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_B2746D8C59CED2B67502CD17BC33307B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_6335EE5584B530107948CD17BC3396ED" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_6335EE5584B530107948CD17BC3396ED" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_MilestonePaymentsSalesBasedMember" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_6F65ED73F970FFE3986FCD17BC335B1A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_32829E8D690525453A85CD17BC3214C5" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_6F65ED73F970FFE3986FCD17BC335B1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_37E5EC1C047520DC8428CD17BC3336C6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_srt_ProductOrServiceAxis_37E5EC1C047520DC8428CD17BC3336C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_37E5EC1C047520DC8428CD17BC3336C6" xlink:to="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_88AAF05B6D8C62AC49CECD17BC33B02D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_TrajentaBIMember_88AAF05B6D8C62AC49CECD17BC33B02D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_56A496D972549245E24ACD17BC34DBAE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_JardianceMember_56A496D972549245E24ACD17BC34DBAE" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_867F94CAE809E19618E7CD17BC34136A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_BasaglarMember_867F94CAE809E19618E7CD17BC34136A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OlumiantMember" xlink:label="loc_lly_OlumiantMember_C6190E7ED00479689AA4CD17BC34FD3D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_OlumiantMember_C6190E7ED00479689AA4CD17BC34FD3D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_3CAAE4BBFEEA214C84DCCD17BC34B4CE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_TanezumabMember_3CAAE4BBFEEA214C84DCCD17BC34B4CE" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LebrikizumabMember" xlink:label="loc_lly_LebrikizumabMember_ACF00D14EAC0C09D0AA5CD17BC35005E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B4733A6B340A5AF00C9DCD17BC33F946" xlink:to="loc_lly_LebrikizumabMember_ACF00D14EAC0C09D0AA5CD17BC35005E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_96D0E13B896DB15F95DACD17BC3518B8" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_srt_StatementGeographicalAxis_96D0E13B896DB15F95DACD17BC3518B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_A7C64DE8CCB0C98169EACD17BC351CDC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_96D0E13B896DB15F95DACD17BC3518B8" xlink:to="loc_srt_SegmentGeographicalDomain_A7C64DE8CCB0C98169EACD17BC351CDC" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_B198B50E51C58AD4F00CCD17BC35E11C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_A7C64DE8CCB0C98169EACD17BC351CDC" xlink:to="loc_country_US_B198B50E51C58AD4F00CCD17BC35E11C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_EuropeMember" xlink:label="loc_srt_EuropeMember_79156D3CDD9D2FA1B123CD17BC35B1AE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_A7C64DE8CCB0C98169EACD17BC351CDC" xlink:to="loc_srt_EuropeMember_79156D3CDD9D2FA1B123CD17BC35B1AE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_JP" xlink:label="loc_country_JP_76F68BC3645402D1B8B9CD17BC36CB99" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_A7C64DE8CCB0C98169EACD17BC351CDC" xlink:to="loc_country_JP_76F68BC3645402D1B8B9CD17BC36CB99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_14DC197040D9AF2FD6C8CD17BC300A83" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_6BD5D6A3E34EA3823123CD17BC361737" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/netLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_6BD5D6A3E34EA3823123CD17BC361737" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_D0D8C355D1230A93EE50CD17BC36D627" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:to="loc_us-gaap_Revenues_D0D8C355D1230A93EE50CD17BC36D627" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_AAC6F93E6D1D9D85EE65CD17BC36213C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_AAC6F93E6D1D9D85EE65CD17BC36213C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_87DDAA53832651F67CB0CD17BC365A8E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_F756FAEB2B54D19DA05ACD17BC3605AE" xlink:to="loc_us-gaap_ContractWithCustomerLiability_87DDAA53832651F67CB0CD17BC365A8E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4B437AB2928963820BA0CD17BC3AF6D6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_E4FDEFC7AF6D8631882BCD17BC3B8611" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4B437AB2928963820BA0CD17BC3AF6D6" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_E4FDEFC7AF6D8631882BCD17BC3B8611" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_B15561B91917FAE8573ECD17BCD81F7F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_B15561B91917FAE8573ECD17BCD81F7F" xlink:to="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_E73ECB2E50CAE6674E49CD17BCD99F00" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_E73ECB2E50CAE6674E49CD17BCD99F00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_26A55A4EAB341E85818ECD17BCD93823" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_ShortTermInvestments_26A55A4EAB341E85818ECD17BCD93823" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_92AE43F58DD5CC6EF2B0CD17BCDA27B4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_92AE43F58DD5CC6EF2B0CD17BCDA27B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherReceivablesNetCurrent" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_36CD1554F3E8A0AC5CEFCD17BCDAAB22" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_36CD1554F3E8A0AC5CEFCD17BCDAAB22" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_0A6FE422AA623346CC62CD17BCDA6CD5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_InventoryNet_0A6FE422AA623346CC62CD17BCDA6CD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_1D198597622CC4C1F177CD17BCDAFEDF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_1D198597622CC4C1F177CD17BCDAFEDF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_B31582D1A708F69CF744CD17BCDAFAA0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_58A8ADB9C2F14B8A2F41CD17BCD906BA" xlink:to="loc_us-gaap_AssetsCurrent_B31582D1A708F69CF744CD17BCDAFAA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_4CD2892A1B31DCCE17A3CD17BCDBADE9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_LongTermInvestments_4CD2892A1B31DCCE17A3CD17BCDBADE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_59BE9C0433EFC142DE69CD17BCDB3AAE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_Goodwill_59BE9C0433EFC142DE69CD17BCDB3AAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_38D38AB8A60630A7670BCD17BCDB6F2D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_38D38AB8A60630A7670BCD17BCDB6F2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_2BEBEDBD9F776A710DD1CD17BCDB3D8D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_2BEBEDBD9F776A710DD1CD17BCDB3D8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_08F505BF3C278C4CBF30CD17BCDB0588" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_08F505BF3C278C4CBF30CD17BCDB0588" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_DC831B8B6BB599A0BFA6CD17BCDB278C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_DC831B8B6BB599A0BFA6CD17BCDB278C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_EDC93AA2451F22E87284CD17BCDCF55E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_7F703AB9D57B3B9F0D47CD17BCD94CEC" xlink:to="loc_us-gaap_Assets_EDC93AA2451F22E87284CD17BCDCF55E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_B15561B91917FAE8573ECD17BCD81F7F" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtCurrent" xlink:label="loc_us-gaap_DebtCurrent_8F2F4E4915C4F6E28277CD17BCDCD5DD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_DebtCurrent_8F2F4E4915C4F6E28277CD17BCDCD5DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_68F6DDAA58191D1E9F2DCD17BCDC4F50" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_AccountsPayableCurrent_68F6DDAA58191D1E9F2DCD17BCDC4F50" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_44C6494F77FFD579CCDFCD17BCDC72B7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_44C6494F77FFD579CCDFCD17BCDC72B7" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SalesRebatesAndDiscounts" xlink:label="loc_lly_SalesRebatesAndDiscounts_05AC6A0DE5360C98A4DFCD17BCDD77A1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_lly_SalesRebatesAndDiscounts_05AC6A0DE5360C98A4DFCD17BCDD77A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaap_DividendsPayableCurrent_4E47CBF5C0FEA64420CBCD17BCDD145F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_DividendsPayableCurrent_4E47CBF5C0FEA64420CBCD17BCDD145F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_2BF11086C204D561EE8BCD17BCDD0621" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_TaxesPayableCurrent_2BF11086C204D561EE8BCD17BCDD0621" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_60E3AA0502F2EEC8EAEBCD17BCDDD6A8" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_60E3AA0502F2EEC8EAEBCD17BCDDD6A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_3FF80009C983C101E35ACD17BCDDA926" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0C5BA5024AFAC5AD21BECD17BCDCE8FD" xlink:to="loc_us-gaap_LiabilitiesCurrent_3FF80009C983C101E35ACD17BCDDA926" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_329A26B51163AC72E59DCD17BCDEE4B6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_329A26B51163AC72E59DCD17BCDEE4B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_B7AA2B6346FC16851DCCCD17BCDE0558" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_B7AA2B6346FC16851DCCCD17BCDE0558" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_8E6BBFB518F64A903AAECD17BCDE14D1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_8E6BBFB518F64A903AAECD17BCDE14D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_81A5E7B4D1966FBDD308CD17BCDEF4F6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_81A5E7B4D1966FBDD308CD17BCDEF4F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_A16DB27F8E1258A13B52CD17BCDECA5D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_A16DB27F8E1258A13B52CD17BCDECA5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_F3E52DD4C94A6E32C510CD17BCDF4B7B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_E7CF87F82F8436D85478CD17BCDDF80D" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_F3E52DD4C94A6E32C510CD17BCDF4B7B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_AFD7583C5F8CD17DA2A2CD17BCDF4322" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_CommitmentsAndContingencies_AFD7583C5F8CD17DA2A2CD17BCDF4322" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_FF3B3397C50B47F8F4D9CD17BCDF5C16" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_CommonStockValue_FF3B3397C50B47F8F4D9CD17BCDF5C16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_08E2588FC17C8B0D03AACD17BCDF66D1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_08E2588FC17C8B0D03AACD17BCDF66D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_37231F02F6DF0DEFA670CD17BCDF804C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_37231F02F6DF0DEFA670CD17BCDF804C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrust" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_61937B707BBB25BD1CE2CD17BCE021D8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_61937B707BBB25BD1CE2CD17BCE021D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_E200823F348BF6C214F1CD17BCE0A86A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_E200823F348BF6C214F1CD17BCE0A86A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_102E781A05A920485AEBCD17BCE07ECB" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_TreasuryStockValue_102E781A05A920485AEBCD17BCE07ECB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_4D2E5A93B5A2EB6C1CD7CD17BCE0345B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_0D3FA049E3DE33199571CD17BCDFD6C4" xlink:to="loc_us-gaap_StockholdersEquity_4D2E5A93B5A2EB6C1CD7CD17BCE0345B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_E11527FFB31B92CC9BA0CD17BCE02E4C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_MinorityInterest_E11527FFB31B92CC9BA0CD17BCE02E4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FAB6AABE4591FB023226CD17BCE1EA81" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_FAB6AABE4591FB023226CD17BCE1EA81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_BF802BD7FA6908D967F9CD17BCE1E2CD" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_A8F5983764C547D3ED4DCD17BCDCD3A2" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_BF802BD7FA6908D967F9CD17BCE1E2CD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReceivablesNetCurrentAbstract" xlink:label="loc_us-gaap_ReceivablesNetCurrentAbstract_8A1E56D14ADAD55C1A5ECD17BCCC5A17" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_43A16FECF2403E593D77CD17BCCC6D07" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesNetCurrentAbstract_8A1E56D14ADAD55C1A5ECD17BCCC5A17" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_43A16FECF2403E593D77CD17BCCC6D07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_D91221C249382836BC37CD17BCCCD542" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesNetCurrentAbstract_8A1E56D14ADAD55C1A5ECD17BCCC5A17" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_D91221C249382836BC37CD17BCCCD542" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_54E53000F5B10FD19CF6CD17BCB04CDC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_54E53000F5B10FD19CF6CD17BCB04CDC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_B2D6566876681A0F1A1ECD17BCB06A77" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_54E53000F5B10FD19CF6CD17BCB04CDC" xlink:to="loc_us-gaap_NetIncomeLoss_B2D6566876681A0F1A1ECD17BCB06A77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_54E53000F5B10FD19CF6CD17BCB04CDC" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_B70EE7C6B159C35E0076CD17BCB133BA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_B70EE7C6B159C35E0076CD17BCB133BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_13735C3BD4C23B755AEDCD17BCB146AF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_13735C3BD4C23B755AEDCD17BCB146AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_935FAA0CFDF8A2496943CD17BCB15E2D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_935FAA0CFDF8A2496943CD17BCB15E2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_AB8DB170D24DE62A6D7BCD17BCB19B1C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_ShareBasedCompensation_AB8DB170D24DE62A6D7BCD17BCB19B1C" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_634B270CF3AC3C7BEDACCD17BCB23BBF" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_634B270CF3AC3C7BEDACCD17BCB23BBF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_880B6D462A2A0C422C13CD17BCB252BF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_880B6D462A2A0C422C13CD17BCB252BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_E243BE9EA863D1C743DDCD17BCB22765" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_563316552739F79AED71CD17BCB1F0B3" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_E243BE9EA863D1C743DDCD17BCB22765" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_23FAA27AE29AC8CAC8B1CD17BCB2A1F9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_54E53000F5B10FD19CF6CD17BCB04CDC" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_23FAA27AE29AC8CAC8B1CD17BCB2A1F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_B5905C0DB30EBBE81869CD17BCB20AD8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_B5905C0DB30EBBE81869CD17BCB20AD8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_D05652D463CB1CCF43C8CD17BCB310CB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_D05652D463CB1CCF43C8CD17BCB310CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_C93F557F7746C3E2BE91CD17BCB39505" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_C93F557F7746C3E2BE91CD17BCB39505" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfLongtermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_D7E096DC8EE0E862A5A4CD17BCB3E2BD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_D7E096DC8EE0E862A5A4CD17BCB3E2BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireLongtermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_0E208E84564B1DD2148DCD17BCB351CE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_0E208E84564B1DD2148DCD17BCB351CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_667DFED4C4939B31F718CD17BCB3C38B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_667DFED4C4939B31F718CD17BCB3C38B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_PurchasedInProcessResearchAndDevelopment" xlink:label="loc_lly_PurchasedInProcessResearchAndDevelopment_564BF78A90AB5130D8EECD17BCB3F3F2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_lly_PurchasedInProcessResearchAndDevelopment_564BF78A90AB5130D8EECD17BCB3F3F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_B41CD61E33CCA7428B65CD17BCB473C3" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_B41CD61E33CCA7428B65CD17BCB473C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3935A0050BF20D6A3FF8CD17BCB424F8" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_DFF8DF9360830CDF6B50CD17BCB269F7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3935A0050BF20D6A3FF8CD17BCB424F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_07E784B0D60C77632390CD17BCB4473A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_PaymentsOfDividends_07E784B0D60C77632390CD17BCB4473A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_09EFFEEC2F1D4D7F3678CD17BCB4B1ED" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_09EFFEEC2F1D4D7F3678CD17BCB4B1ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_5715E0630D02677E7418CD17BCB56EE4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_5715E0630D02677E7418CD17BCB56EE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_119E0612705D71D4DDDFCD17BCB5160E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_119E0612705D71D4DDDFCD17BCB5160E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_E53EBB5CB1C42FD21C04CD17BCB56714" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_E53EBB5CB1C42FD21C04CD17BCB56714" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_B8FDE79919FBAA5338E6CD17BCB54323" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_B8FDE79919FBAA5338E6CD17BCB54323" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9544B93DF27C0B2754C7CD17BCB56344" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_ED1D34DD8D2F6FE20FBBCD17BCB46D7F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9544B93DF27C0B2754C7CD17BCB56344" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_045A64A5CC8BDF29E0D0CD17BCB57200" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_045A64A5CC8BDF29E0D0CD17BCB57200" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_078491E3BD7478A2EBFFCD17BCB6383A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_078491E3BD7478A2EBFFCD17BCB6383A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_7DBEAEFB07B6BB9B1C44CD17BCB6F677" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_7DBEAEFB07B6BB9B1C44CD17BCB6F677" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_F174748AF2D37BE8D4B6CD17BCB660A2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_F174748AF2D37BE8D4B6CD17BCB660A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_EDE20BDE2D705E57185DCD17BCB63881" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_1DF226041AE26FFC80C7CD17BCB068C3" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_EDE20BDE2D705E57185DCD17BCB63881" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlowsUnauditedParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_3FCF38A0147E9784F0C8CD17BCA6F7B1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsDisposalGroupIncludingDiscontinuedOperations" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsDisposalGroupIncludingDiscontinuedOperations_B41E884AD35996FCA740CD17BCA6C129" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3FCF38A0147E9784F0C8CD17BCA6F7B1" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsDisposalGroupIncludingDiscontinuedOperations_B41E884AD35996FCA740CD17BCA6C129" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_611123B88D9DBC12C621CD17BCEED81A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_53C1A98E615FDA1C1799CD17BCEEE596" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_611123B88D9DBC12C621CD17BCEED81A" xlink:to="loc_us-gaap_StatementTable_53C1A98E615FDA1C1799CD17BCEEE596" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_A354613FE6E97E18D305CD17BCEEAB46" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_53C1A98E615FDA1C1799CD17BCEEE596" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_A354613FE6E97E18D305CD17BCEEAB46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_A14CB9CF1E03378AE52ACD17BCEFB2E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_A354613FE6E97E18D305CD17BCEEAB46" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_A14CB9CF1E03378AE52ACD17BCEFB2E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentContinuingOperationsMember" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_914ADE1D99B983C97C8ECD17BCEF0B7D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_A14CB9CF1E03378AE52ACD17BCEFB2E5" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_914ADE1D99B983C97C8ECD17BCEF0B7D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDiscontinuedOperationsMember" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_43987145C9187CBD30B3CD17BCEF5DE1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_A14CB9CF1E03378AE52ACD17BCEFB2E5" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_43987145C9187CBD30B3CD17BCEF5DE1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_0AAE8191736934D20347CD17BCEF1A6A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_53C1A98E615FDA1C1799CD17BCEEE596" xlink:to="loc_us-gaap_StatementLineItems_0AAE8191736934D20347CD17BCEF1A6A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_0D03887037C4EF7FEFF2CD17BCEF2CD6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0AAE8191736934D20347CD17BCEF1A6A" xlink:to="loc_us-gaap_NetIncomeLoss_0D03887037C4EF7FEFF2CD17BCEF2CD6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_875950EA6459B7BB9892CD17BCF04FFF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0AAE8191736934D20347CD17BCEF1A6A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_875950EA6459B7BB9892CD17BCF04FFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_1652F836A0160FCE2C56CD17BCF0E214" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0AAE8191736934D20347CD17BCEF1A6A" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_1652F836A0160FCE2C56CD17BCF0E214" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfEquityUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_5942F66AD5611482222CCD17BCC287E2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_8D0627A60607A9C58C7ACD17BCC2EFFC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_5942F66AD5611482222CCD17BCC287E2" xlink:to="loc_us-gaap_StatementTable_8D0627A60607A9C58C7ACD17BCC2EFFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_933CBB34D29F63E0D1D7CD17BCC2BE35" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8D0627A60607A9C58C7ACD17BCC2EFFC" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_933CBB34D29F63E0D1D7CD17BCC2BE35" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_933CBB34D29F63E0D1D7CD17BCC2BE35" xlink:to="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_6A9892A14B5BDB2056DECD17BCC32372" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_CommonStockMember_6A9892A14B5BDB2056DECD17BCC32372" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_403C78F43183D2A055A6CD17BCC3169F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_403C78F43183D2A055A6CD17BCC3169F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_A62FBADFBAFAFA97D146CD17BCC35B4B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_RetainedEarningsMember_A62FBADFBAFAFA97D146CD17BCC35B4B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TrustForBenefitOfEmployeesMember" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_9D60DF2951D1F5323162CD17BCC3E3E1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_9D60DF2951D1F5323162CD17BCC3E3E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_36DF1A01F57682D682EACD17BCC48016" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_36DF1A01F57682D682EACD17BCC48016" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_C4D16A35FA953B3009FACD17BCC49FFC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_TreasuryStockMember_C4D16A35FA953B3009FACD17BCC49FFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_2BB10625A493F6F3BE74CD17BCC4DC53" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_A112988F006C928F6DB2CD17BCC31BDE" xlink:to="loc_us-gaap_NoncontrollingInterestMember_2BB10625A493F6F3BE74CD17BCC4DC53" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F155802AC483A55A7EB2CD17BCC43C1A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8D0627A60607A9C58C7ACD17BCC2EFFC" xlink:to="loc_us-gaap_StatementLineItems_F155802AC483A55A7EB2CD17BCC43C1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F155802AC483A55A7EB2CD17BCC43C1A" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_59FD70DB034365F98A8BCD17BCC5F96C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_SharesIssued_59FD70DB034365F98A8BCD17BCC5F96C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_CB028A22A3D7DDF64E06CD17BCC5272B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_CB028A22A3D7DDF64E06CD17BCC5272B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_F949A34ACE0C3D919AB4CD17BCC5BE28" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_ProfitLoss_F949A34ACE0C3D919AB4CD17BCC5BE28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_F8EE09DAFA4C687731CBCD17BCC5F0C8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_F8EE09DAFA4C687731CBCD17BCC5F0C8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockSharesRetired" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_EDC1472FCA15B49F350FCD17BCC55804" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_EDC1472FCA15B49F350FCD17BCC55804" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_36D22A1C5539EA441FF7CD17BCC5EB34" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_36D22A1C5539EA441FF7CD17BCC5EB34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_D98E6D8045756344F15FCD17BCC65B4B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_D98E6D8045756344F15FCD17BCC65B4B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_CB992B3AACF80988B029CD17BCC6ED0F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_CB992B3AACF80988B029CD17BCC6ED0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_9873CE1040B9743562B6CD17BCC6BB32" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_9873CE1040B9743562B6CD17BCC6BB32" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_B0D7D7B0FDCCC6E5C357CD17BCC63FF3" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_B0D7D7B0FDCCC6E5C357CD17BCC63FF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_F1FBC837041DE52953EECD17BCC6F85F" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_F1FBC837041DE52953EECD17BCC6F85F" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_StockAcquiredDuringPeriodSharesExchangeOffer" xlink:label="loc_lly_StockAcquiredDuringPeriodSharesExchangeOffer_FD9A1E74C80834B4BD08CD17BCC602FD" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_lly_StockAcquiredDuringPeriodSharesExchangeOffer_FD9A1E74C80834B4BD08CD17BCC602FD" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_StockAcquiredDuringPeriodValueExchangeOffer" xlink:label="loc_lly_StockAcquiredDuringPeriodValueExchangeOffer_816F938604F15000D8FECD17BCC7C05F" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_lly_StockAcquiredDuringPeriodValueExchangeOffer_816F938604F15000D8FECD17BCC7C05F" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary" xlink:label="loc_lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary_FB27865F123CD6AEF53BCD17BCC726FB" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary_FB27865F123CD6AEF53BCD17BCC726FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityOther" xlink:label="loc_us-gaap_StockholdersEquityOther_AEBA44615C504A36FBA1CD17BCC7C5CD" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockholdersEquityOther_AEBA44615C504A36FBA1CD17BCC7C5CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_9DE6015DE49025EA2D41CD17BCC73551" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_SharesIssued_9DE6015DE49025EA2D41CD17BCC73551" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_907C7BF9825782A1F7D2CD17BCC74CDA" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_16A23F63C13CBB6DD434CD17BCC4C821" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_907C7BF9825782A1F7D2CD17BCC74CDA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfEquityUnauditedParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_104D5262070B250D815FCD17BCBC4AEA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_E2AB632C21533F842499CD17BCBC5212" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_104D5262070B250D815FCD17BCBC4AEA" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_E2AB632C21533F842499CD17BCBC5212" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0FCDAF743E57D739068ACD17BCBCEF9B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_104D5262070B250D815FCD17BCBC4AEA" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0FCDAF743E57D739068ACD17BCBCEF9B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfOperationsUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_F94D28D82DD8380A860FCD17BCF74500" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_Revenues_F94D28D82DD8380A860FCD17BCF74500" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_1D00C3C6E054B02BA221CD17BCF7DD7C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_1D00C3C6E054B02BA221CD17BCF7DD7C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_EB7927CF9C98DB87D718CD17BCF77B59" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_EB7927CF9C98DB87D718CD17BCF77B59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_7AFD5B6307CF68A2D91CCD17BCF8B84A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_7AFD5B6307CF68A2D91CCD17BCF8B84A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_744A9D7F68F041BE4A39CD17BCF81B69" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_744A9D7F68F041BE4A39CD17BCF81B69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_923941B9C98C4638D7B2CD17BCF8E63B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_923941B9C98C4638D7B2CD17BCF8E63B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_C025B20EBEB286AF0D5DCD17BCF86FBC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_C025B20EBEB286AF0D5DCD17BCF86FBC" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CostOfSalesOperatingExpensesAndOtherNet" xlink:label="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_FD953F8A7686651C169BCD17BCF8A652" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_43478694DEE8275D1A73CD17BCF7F0E0" xlink:to="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_FD953F8A7686651C169BCD17BCF8A652" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BF7EADBA45507F6B90EDCD17BCF89FDD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BF7EADBA45507F6B90EDCD17BCF89FDD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_07B47F284C31814CC1F3CD17BCF8AEA6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_07B47F284C31814CC1F3CD17BCF8AEA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_2EC492066FACD5B0962CCD17BCF905E6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_2EC492066FACD5B0962CCD17BCF905E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_BBC37EF2306C15BFA2F4CD17BCF93326" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_BBC37EF2306C15BFA2F4CD17BCF93326" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_5664762F5472ABE746D6CD17BCF9C7C2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_NetIncomeLoss_5664762F5472ABE746D6CD17BCF9C7C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_947E619D313A5B418944CD17BCF99F74" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_947E619D313A5B418944CD17BCF99F74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_9F333B057A0BAC4F5165CD17BCF92AE9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_9F333B057A0BAC4F5165CD17BCF92AE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_D4101524937555B04682CD17BCFA8CF8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_EarningsPerShareBasic_D4101524937555B04682CD17BCFA8CF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_F55AF6CF91C41B0D1C12CD17BCFAF7ED" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_F55AF6CF91C41B0D1C12CD17BCFAF7ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_B94E5BA0211F1A5EB9BECD17BCFA9093" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_B94E5BA0211F1A5EB9BECD17BCFA9093" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_03DC6DC954AFEFEF3B06CD17BCFABB85" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EF46E348502D88C81F63CD17BCF989EB" xlink:to="loc_us-gaap_EarningsPerShareDiluted_03DC6DC954AFEFEF3B06CD17BCFABB85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_EF99598CB2CCFF83E6B1CD17BCFAFE48" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_10711FF4F8BEB52237F4CD17BCF6EFEC" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_EF99598CB2CCFF83E6B1CD17BCFAFE48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1047D619A484EB209BADCD17BCFAC377" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_EF99598CB2CCFF83E6B1CD17BCFAFE48" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1047D619A484EB209BADCD17BCFAC377" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_35B5D83DFDECBD7E141BCD17BCFBD4D9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_EF99598CB2CCFF83E6B1CD17BCFAFE48" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_35B5D83DFDECBD7E141BCD17BCFBD4D9" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/Contingencies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CC408D238155AD69889ACD17BAF1568E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_48606E6A9667B5145394CD17BAF123DF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CC408D238155AD69889ACD17BAF1568E" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_48606E6A9667B5145394CD17BAF123DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_6DC255BBAD08CA016156CD17BAE2A221" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_6DC255BBAD08CA016156CD17BAE2A221" xlink:to="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementScenarioAxis" xlink:label="loc_srt_StatementScenarioAxis_CBD869F37158F8A63A35CD17BAE333CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:to="loc_srt_StatementScenarioAxis_CBD869F37158F8A63A35CD17BAE333CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="loc_srt_ScenarioUnspecifiedDomain_CF72B2C61D7696063F61CD17BAE3463D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementScenarioAxis_CBD869F37158F8A63A35CD17BAE333CA" xlink:to="loc_srt_ScenarioUnspecifiedDomain_CF72B2C61D7696063F61CD17BAE3463D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioForecastMember" xlink:label="loc_srt_ScenarioForecastMember_C827EB7D2CA5AFCE8D95CD17BAE3FFA4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ScenarioUnspecifiedDomain_CF72B2C61D7696063F61CD17BAE3463D" xlink:to="loc_srt_ScenarioForecastMember_C827EB7D2CA5AFCE8D95CD17BAE3FFA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_B2EDC0D510404FBBFE6DCD17BAE35364" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:to="loc_srt_StatementGeographicalAxis_B2EDC0D510404FBBFE6DCD17BAE35364" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_0871C2D2994FC1CA9C54CD17BAE3B838" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_B2EDC0D510404FBBFE6DCD17BAE35364" xlink:to="loc_srt_SegmentGeographicalDomain_0871C2D2994FC1CA9C54CD17BAE3B838" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_BR" xlink:label="loc_country_BR_4743F706AFE3B97380FACD17BAE4B60E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_0871C2D2994FC1CA9C54CD17BAE3B838" xlink:to="loc_country_BR_4743F706AFE3B97380FACD17BAE4B60E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseAxis" xlink:label="loc_srt_LitigationCaseAxis_DC47A7E0782C284F6025CD17BAE438A3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:to="loc_srt_LitigationCaseAxis_DC47A7E0782C284F6025CD17BAE438A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain" xlink:label="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseAxis_DC47A7E0782C284F6025CD17BAE438A3" xlink:to="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DrReddysLabMember" xlink:label="loc_lly_DrReddysLabMember_D1EB613838FB76481355CD17BAE5F973" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:to="loc_lly_DrReddysLabMember_D1EB613838FB76481355CD17BAE5F973" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_JapaneseAdministrativeProceedingsMember" xlink:label="loc_lly_JapaneseAdministrativeProceedingsMember_2B16258937BBDB423ADCCD17BAE51BD9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:to="loc_lly_JapaneseAdministrativeProceedingsMember_2B16258937BBDB423ADCCD17BAE51BD9" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_EmgalityPatentLitigationMember" xlink:label="loc_lly_EmgalityPatentLitigationMember_6DDDD59AFDCB355EFEE1CD17BAE5EB95" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:to="loc_lly_EmgalityPatentLitigationMember_6DDDD59AFDCB355EFEE1CD17BAE5EB95" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_EmployeeLitigationMember" xlink:label="loc_lly_EmployeeLitigationMember_4C3765B7EA0AC19A400CCD17BAE5F6E6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:to="loc_lly_EmployeeLitigationMember_4C3765B7EA0AC19A400CCD17BAE5F6E6" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember" xlink:label="loc_lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember_B0F5EECF3D8A578A32E6CD17BAE516E0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_19D8B1A11E23B904E2CBCD17BAE4DC69" xlink:to="loc_lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember_B0F5EECF3D8A578A32E6CD17BAE516E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_646BEFEF34C12C4850FECD17BAE2EE67" xlink:to="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyClaimsSettledAndDismissedNumber" xlink:label="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_E5703D1BE75F0F8D4F50CD17BAE65CAD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_E5703D1BE75F0F8D4F50CD17BAE65CAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyPendingClaimsNumber" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_686520D0D4D2842514D8CD17BAE63039" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_686520D0D4D2842514D8CD17BAE63039" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm" xlink:label="loc_lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm_B8E0F7E6D990E0355837CD17BAE64E70" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm_B8E0F7E6D990E0355837CD17BAE64E70" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberofDemands" xlink:label="loc_lly_LossContingencyNumberofDemands_4286339FDF8FE47EB445CD17BAE6C944" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberofDemands_4286339FDF8FE47EB445CD17BAE6C944" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_NumberofPatents" xlink:label="loc_lly_NumberofPatents_412EEA144632F2AAF1FACD17BAE62043" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_NumberofPatents_412EEA144632F2AAF1FACD17BAE62043" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberOfPatents" xlink:label="loc_lly_LossContingencyNumberOfPatents_D8E17F5689CDD5BC599ECD17BAE7564A" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberOfPatents_D8E17F5689CDD5BC599ECD17BAE7564A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberOfPatentsClaimsDismissed" xlink:label="loc_lly_LossContingencyNumberOfPatentsClaimsDismissed_BE2FD88251074FDF1BB5CD17BAE766C7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberOfPatentsClaimsDismissed_BE2FD88251074FDF1BB5CD17BAE766C7" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberOfPatentsClaimsDecisionExpected" xlink:label="loc_lly_LossContingencyNumberOfPatentsClaimsDecisionExpected_754DA73D88A8BACF4ED9CD17BAE7B081" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberOfPatentsClaimsDecisionExpected_754DA73D88A8BACF4ED9CD17BAE7B081" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyRequisiteServicePeriodAffectedYears" xlink:label="loc_lly_LossContingencyRequisiteServicePeriodAffectedYears_9BA2504E37D232C23A5FCD17BAE7F28F" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyRequisiteServicePeriodAffectedYears_9BA2504E37D232C23A5FCD17BAE7F28F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_F342791F18A4B4B0F4B3CD17BAE7EC70" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_F342791F18A4B4B0F4B3CD17BAE7EC70" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberOfLawsuits" xlink:label="loc_lly_LossContingencyNumberOfLawsuits_0393ED5CB004F2F02D9ACD17BAE7A790" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberOfLawsuits_0393ED5CB004F2F02D9ACD17BAE7A790" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_LossContingencyNumberOfRequestsForInformation" xlink:label="loc_lly_LossContingencyNumberOfRequestsForInformation_4F091212754D28D76EFCCD17BAE73D5A" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_6D0F44FC729A4FAE0549CD17BAE55898" xlink:to="loc_lly_LossContingencyNumberOfRequestsForInformation_4F091212754D28D76EFCCD17BAE73D5A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract" xlink:label="loc_dei_CoverAbstract_28B2FBB8EDBD02B88D8ACD17BD022E4C" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationTable" xlink:label="loc_dei_DocumentInformationTable_8F5AF2BFE9649F072CC3CD17BD0283B5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_28B2FBB8EDBD02B88D8ACD17BD022E4C" xlink:to="loc_dei_DocumentInformationTable_8F5AF2BFE9649F072CC3CD17BD0283B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2747F0EB91645A7DEC70CD17BD020CF0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_8F5AF2BFE9649F072CC3CD17BD0283B5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2747F0EB91645A7DEC70CD17BD020CF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2747F0EB91645A7DEC70CD17BD020CF0" xlink:to="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_41859047AD410A3F6098CD17BD03BA6D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_us-gaap_CommonClassAMember_41859047AD410A3F6098CD17BD03BA6D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A1.000NotesDueJune22022Member" xlink:label="loc_lly_A1.000NotesDueJune22022Member_9D7DF56D07B1CACF8F75CD17BD034486" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A1.000NotesDueJune22022Member_9D7DF56D07B1CACF8F75CD17BD034486" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A718NotesDueJune12025Member" xlink:label="loc_lly_A718NotesDueJune12025Member_E7AE46153590AB8A565CCD17BD03B4BD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A718NotesDueJune12025Member_E7AE46153590AB8A565CCD17BD03B4BD" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A1.625NotesDueJune22026Member" xlink:label="loc_lly_A1.625NotesDueJune22026Member_034F195DDAAC1B9024C3CD17BD03BEAB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A1.625NotesDueJune22026Member_034F195DDAAC1B9024C3CD17BD03BEAB" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A2.125NotesDueJune32030Member" xlink:label="loc_lly_A2.125NotesDueJune32030Member_1F964519DC683F2186CBCD17BD039D06" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A2.125NotesDueJune32030Member_1F964519DC683F2186CBCD17BD039D06" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A625Notesdue2031Member" xlink:label="loc_lly_A625Notesdue2031Member_6E2B5559B2C40454CC66CD17BD042671" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A625Notesdue2031Member_6E2B5559B2C40454CC66CD17BD042671" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A6.77NotesDueJanuary12036Member" xlink:label="loc_lly_A6.77NotesDueJanuary12036Member_A8F3EB6CC0BE7A6CD15BCD17BD04CBD5" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A6.77NotesDueJanuary12036Member_A8F3EB6CC0BE7A6CD15BCD17BD04CBD5" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_A1.700Notesdue2049Member" xlink:label="loc_lly_A1.700Notesdue2049Member_99B62452C8A6D9D96DFBCD17BD04E4AC" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_537890B14EBE1316F15DCD17BD02811D" xlink:to="loc_lly_A1.700Notesdue2049Member_99B62452C8A6D9D96DFBCD17BD04E4AC" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationLineItems" xlink:label="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_8F5AF2BFE9649F072CC3CD17BD0283B5" xlink:to="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentQuarterlyReport" xlink:label="loc_dei_DocumentQuarterlyReport_270FF82CFAD88CE94562CD17BD04E6E2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentQuarterlyReport_270FF82CFAD88CE94562CD17BD04E6E2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentTransitionReport" xlink:label="loc_dei_DocumentTransitionReport_30EF19B2302CF2D2948BCD17BD048FFB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentTransitionReport_30EF19B2302CF2D2948BCD17BD048FFB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_A5AEDDD7A7F7CB26657ACD17BD04A040" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_AmendmentFlag_A5AEDDD7A7F7CB26657ACD17BD04A040" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_101FA0419717B9D1FC91CD17BD053642" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentFiscalYearFocus_101FA0419717B9D1FC91CD17BD053642" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_544ACD9A787C39FFE769CD17BD05F4DE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentFiscalPeriodFocus_544ACD9A787C39FFE769CD17BD05F4DE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_7CEF8C7D921C88EEA052CD17BD05EF2C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityCentralIndexKey_7CEF8C7D921C88EEA052CD17BD05EF2C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_42FD645E85CAC652C292CD17BD05DAFE" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_CurrentFiscalYearEndDate_42FD645E85CAC652C292CD17BD05DAFE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_34F95731182EBE645AA4CD17BD05E852" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentType_34F95731182EBE645AA4CD17BD05E852" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_C56BC88194999F958AE7CD17BD060BD9" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_DocumentPeriodEndDate_C56BC88194999F958AE7CD17BD060BD9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_A65670A2A881A70FF1B9CD17BD062032" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityFileNumber_A65670A2A881A70FF1B9CD17BD062032" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_CE10DDE0DD4C3C18F2D8CD17BD0692D9" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityRegistrantName_CE10DDE0DD4C3C18F2D8CD17BD0692D9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_4A709BFB05D720AA2204CD17BD062528" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityIncorporationStateCountryCode_4A709BFB05D720AA2204CD17BD062528" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_3496A5360B578D2B9BA4CD17BD06B612" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityTaxIdentificationNumber_3496A5360B578D2B9BA4CD17BD06B612" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_710222F12F9CCE948A76CD17BD06DEE0" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityAddressAddressLine1_710222F12F9CCE948A76CD17BD06DEE0" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_F230F7534DCF36B2967ACD17BD071C25" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityAddressCityOrTown_F230F7534DCF36B2967ACD17BD071C25" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_8F65CB61EC65C6F5F6F5CD17BD07A4A7" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityAddressStateOrProvince_8F65CB61EC65C6F5F6F5CD17BD07A4A7" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_1BB00FB8F02D4EB65D81CD17BD07B5ED" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityAddressPostalZipCode_1BB00FB8F02D4EB65D81CD17BD07B5ED" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_F1DA7F7BBA87C62E63A5CD17BD07D24A" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_CityAreaCode_F1DA7F7BBA87C62E63A5CD17BD07D24A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_3A6861DE71262AE55C5DCD17BD07CF25" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_LocalPhoneNumber_3A6861DE71262AE55C5DCD17BD07CF25" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_96C498539505773E919DCD17BD07C5FE" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_Security12bTitle_96C498539505773E919DCD17BD07C5FE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_138725F2C66FF368BB1CCD17BD0813B3" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_TradingSymbol_138725F2C66FF368BB1CCD17BD0813B3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_84F8795C29C1CD88B1B7CD17BD08D621" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_SecurityExchangeName_84F8795C29C1CD88B1B7CD17BD08D621" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_216C75094EC7BA2EB60ACD17BD088EC2" xlink:type="locator" />
    <link:presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityCurrentReportingStatus_216C75094EC7BA2EB60ACD17BD088EC2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInteractiveDataCurrent" xlink:label="loc_dei_EntityInteractiveDataCurrent_C1007717A19D7546D259CD17BD082ABA" xlink:type="locator" />
    <link:presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityInteractiveDataCurrent_C1007717A19D7546D259CD17BD082ABA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_0AAF7B1A132C0D0E7CF8CD17BD086329" xlink:type="locator" />
    <link:presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityFilerCategory_0AAF7B1A132C0D0E7CF8CD17BD086329" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_81A95150247FA115678FCD17BD08DB9E" xlink:type="locator" />
    <link:presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntitySmallBusiness_81A95150247FA115678FCD17BD08DB9E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_3500AA1CB361ABF0BA8BCD17BD0860CA" xlink:type="locator" />
    <link:presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityEmergingGrowthCompany_3500AA1CB361ABF0BA8BCD17BD0860CA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_F338CEF4312024463BF8CD17BD099D9A" xlink:type="locator" />
    <link:presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityShellCompany_F338CEF4312024463BF8CD17BD099D9A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_3DB20359F35ACB3F0BB1CD17BD09268E" xlink:type="locator" />
    <link:presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6DDA3279D81A6788F1F8CD17BD04EEAD" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_3DB20359F35ACB3F0BB1CD17BD09268E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/DiscontinuedOperations" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_E4874DEFEFFCA9F4FDF2CD17BC2A3A00" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_071A6EA5ADAC933CFA07CD17BC2AE210" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_E4874DEFEFFCA9F4FDF2CD17BC2A3A00" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_071A6EA5ADAC933CFA07CD17BC2AE210" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/DiscontinuedOperationsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_7EFB40AC85CB8CFC5343CD17BBF56D74" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_7EFB40AC85CB8CFC5343CD17BBF56D74" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_OwnershipAxis" xlink:label="loc_srt_OwnershipAxis_677238E8555CE9803348CD17BBF5DB89" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:to="loc_srt_OwnershipAxis_677238E8555CE9803348CD17BBF5DB89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_OwnershipDomain" xlink:label="loc_srt_OwnershipDomain_8997C6DD124B307A5270CD17BBF63FF2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipAxis_677238E8555CE9803348CD17BBF5DB89" xlink:to="loc_srt_OwnershipDomain_8997C6DD124B307A5270CD17BBF63FF2" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_EliLillyAndCompanyMember" xlink:label="loc_lly_EliLillyAndCompanyMember_C71D96B67CE8A9F27974CD17BBF65A59" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_8997C6DD124B307A5270CD17BBF63FF2" xlink:to="loc_lly_EliLillyAndCompanyMember_C71D96B67CE8A9F27974CD17BBF65A59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_A6EAE13E329B6D85B9E4CD17BBF62BF6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_A6EAE13E329B6D85B9E4CD17BBF62BF6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_C291ABAD8199F74342DECD17BBF61AA1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_A6EAE13E329B6D85B9E4CD17BBF62BF6" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_C291ABAD8199F74342DECD17BBF61AA1" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_609AAD5D59E65C1E1599CD17BBF7FFD2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_C291ABAD8199F74342DECD17BBF61AA1" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_609AAD5D59E65C1E1599CD17BBF7FFD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_3A422DD93B0D91B7BBCECD17BBF79547" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_3A422DD93B0D91B7BBCECD17BBF79547" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_48EA3948CF03C199882ACD17BBF77828" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_3A422DD93B0D91B7BBCECD17BBF79547" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_48EA3948CF03C199882ACD17BBF77828" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_2239592E1A392AE426DDCD17BC22445C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_48EA3948CF03C199882ACD17BBF77828" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_2239592E1A392AE426DDCD17BC22445C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_FCAC8ED0E2DB2B292EB0CD17BBF5B91B" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_03DA259790F252507A16CD17BC2369F7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_03DA259790F252507A16CD17BC2369F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_DE735208B4B27199D864CD17BC2390EA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_DE735208B4B27199D864CD17BC2390EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_C1BD1CA270140C85F478CD17BC2355AC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_C1BD1CA270140C85F478CD17BC2355AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_DBDFB53E9067719973C8CD17BC23EBA8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_DBDFB53E9067719973C8CD17BC23EBA8" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm" xlink:label="loc_lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm_5AA15AFBFB6116E531A7CD17BC24CF91" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_83853C2345BAFB207665CD17BC23C37D" xlink:to="loc_lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm_5AA15AFBFB6116E531A7CD17BC24CF91" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstruments" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_D4E1184CE48AED52D779CD17BBE01CD2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_CD196543413955DD21DBCD17BBE1179D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_D4E1184CE48AED52D779CD17BBE01CD2" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_CD196543413955DD21DBCD17BBE1179D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsContractualMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4577BC30F68E08BF566CCD17BB9D7744" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4577BC30F68E08BF566CCD17BB9D7744" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_79FCE3E9C2BE7E0A7159CD17BB9D1BC3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_79FCE3E9C2BE7E0A7159CD17BB9D1BC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_B8384565CFF7AB9093FECD17BB9D1615" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_B8384565CFF7AB9093FECD17BB9D1615" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_61DC2A1C8772EE9F1B23CD17BB9E1CAF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_61DC2A1C8772EE9F1B23CD17BB9E1CAF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_A3C3B204987DC58933FACD17BB9EE7CF" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_DC86010615F25D497E3BCD17BB9D16CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_A3C3B204987DC58933FACD17BB9EE7CF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsEffectOfRiskManagementInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_951373E26CFB7A028F99CD17BBC058B5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1BB26E7EFCF83CA9FE19CD17BBC0C6E6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_951373E26CFB7A028F99CD17BBC058B5" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1BB26E7EFCF83CA9FE19CD17BBC0C6E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_E6350B1C940F167DDE2BCD17BBC0B1D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1BB26E7EFCF83CA9FE19CD17BBC0C6E6" xlink:to="loc_us-gaap_HedgingDesignationAxis_E6350B1C940F167DDE2BCD17BBC0B1D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_89525696AAC7A01A50A3CD17BBC017E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_E6350B1C940F167DDE2BCD17BBC0B1D8" xlink:to="loc_us-gaap_HedgingDesignationDomain_89525696AAC7A01A50A3CD17BBC017E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_6D73229A28B61C1826F1CD17BBC1ECA0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_89525696AAC7A01A50A3CD17BBC017E1" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_6D73229A28B61C1826F1CD17BBC1ECA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_DD7586E355B124EBC515CD17BBC12259" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_89525696AAC7A01A50A3CD17BBC017E1" xlink:to="loc_us-gaap_NondesignatedMember_DD7586E355B124EBC515CD17BBC12259" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_C8651FBAE8B68BABFDDACD17BBC1F222" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1BB26E7EFCF83CA9FE19CD17BBC0C6E6" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_C8651FBAE8B68BABFDDACD17BBC1F222" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_C8651FBAE8B68BABFDDACD17BBC1F222" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_HedgedFixedRateDebtMember" xlink:label="loc_lly_HedgedFixedRateDebtMember_114A733ED6F1F3F7AF65CD17BBC1DA92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:to="loc_lly_HedgedFixedRateDebtMember_114A733ED6F1F3F7AF65CD17BBC1DA92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_717F0B90A8547BE878E0CD17BBC25260" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:to="loc_us-gaap_InterestRateContractMember_717F0B90A8547BE878E0CD17BBC25260" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_9D24AC51D8AA3F8BAC1FCD17BBC29E5F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_9D24AC51D8AA3F8BAC1FCD17BBC29E5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_65E6D750B1653C0AEAD7CD17BBC28D3C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:to="loc_us-gaap_ForeignExchangeContractMember_65E6D750B1653C0AEAD7CD17BBC28D3C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_B806F6FF089A4B78B4D7CD17BBC26195" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_D7DA7CA6D432039E1F40CD17BBC1E850" xlink:to="loc_us-gaap_InterestRateSwapMember_B806F6FF089A4B78B4D7CD17BBC26195" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1BB26E7EFCF83CA9FE19CD17BBC0C6E6" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_FairValueHedgeAbstract" xlink:label="loc_lly_FairValueHedgeAbstract_F0BB74A6B49F6B72ABDCCD17BBC2C6DF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_lly_FairValueHedgeAbstract_F0BB74A6B49F6B72ABDCCD17BBC2C6DF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_8CB680FA680D886A44E6CD17BBC3D454" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_FairValueHedgeAbstract_F0BB74A6B49F6B72ABDCCD17BBC2C6DF" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_8CB680FA680D886A44E6CD17BBC3D454" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_E9AE8A7BE288052C2081CD17BBC37BAD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_FairValueHedgeAbstract_F0BB74A6B49F6B72ABDCCD17BBC2C6DF" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_E9AE8A7BE288052C2081CD17BBC37BAD" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CashFlowHedgeAbstract" xlink:label="loc_lly_CashFlowHedgeAbstract_74E3595D0586DF10A0CCCD17BBC34FC7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_lly_CashFlowHedgeAbstract_74E3595D0586DF10A0CCCD17BBC34FC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_8E71F23431766115EFEBCD17BBC40B7F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_CashFlowHedgeAbstract_74E3595D0586DF10A0CCCD17BBC34FC7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_8E71F23431766115EFEBCD17BBC40B7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_EEBADF8B28DB4568B263CD17BBC4E278" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_EEBADF8B28DB4568B263CD17BBC4E278" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DerivativeInstrumentsGainLossRecognized" xlink:label="loc_lly_DerivativeInstrumentsGainLossRecognized_AF0207278046C2B72AD2CD17BBC40B58" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_lly_DerivativeInstrumentsGainLossRecognized_AF0207278046C2B72AD2CD17BBC40B58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_0E374783F3FA3901D85FCD17BBC40D6B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_0E374783F3FA3901D85FCD17BBC40D6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_68BA65BDCDD582CDEB24CD17BBC4FB6F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AEE2466DCAFB58865FD9CD17BBC2A21A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_68BA65BDCDD582CDEB24CD17BBC4FB6F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsFairValueOfFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_B87043D96F67807C83CCCD17BBB16A35" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_B87043D96F67807C83CCCD17BBB16A35" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_25E2221DA3D1650CC15FCD17BBB22814" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:to="loc_us-gaap_FinancialInstrumentAxis_25E2221DA3D1650CC15FCD17BBB22814" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_25E2221DA3D1650CC15FCD17BBB22814" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_C95BC5698EA63FCA7703CD17BBB29E92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_C95BC5698EA63FCA7703CD17BBB29E92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_2D03C273ED837D74999CCD17BBB34D14" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_2D03C273ED837D74999CCD17BBB34D14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_D8CC8F4BC0491AC31399CD17BBB3BA1D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_D8CC8F4BC0491AC31399CD17BBB3BA1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherDebtSecuritiesMember" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_1B88A8B93D57054E82ABCD17BBB38F2F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_1B88A8B93D57054E82ABCD17BBB38F2F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_68754F39303DA5FAB606CD17BBB3C85F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_68754F39303DA5FAB606CD17BBB3C85F" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherEquitySecuritiesMember" xlink:label="loc_lly_OtherEquitySecuritiesMember_4530E6A7E4CBAA293C04CD17BBB3387B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_lly_OtherEquitySecuritiesMember_4530E6A7E4CBAA293C04CD17BBB3387B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_MarketableSecuritiesMember" xlink:label="loc_lly_MarketableSecuritiesMember_7069F7F2F293397DF447CD17BBB3B975" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_lly_MarketableSecuritiesMember_7069F7F2F293397DF447CD17BBB3B975" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_EquityMethodAndOtherInvestmentsMember" xlink:label="loc_lly_EquityMethodAndOtherInvestmentsMember_361A8AE22D840BD70A01CD17BBB4753C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_E9F52CE55210A6971764CD17BBB2D6E1" xlink:to="loc_lly_EquityMethodAndOtherInvestmentsMember_361A8AE22D840BD70A01CD17BBB4753C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_C6B0EF871E4D1CF834B6CD17BBB40D72" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_C6B0EF871E4D1CF834B6CD17BBB40D72" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_7E4977F79AED4AE060D9CD17BBB4AB6E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_C6B0EF871E4D1CF834B6CD17BBB40D72" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_7E4977F79AED4AE060D9CD17BBB4AB6E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_D6E06EC978F7962CF8CFCD17BBB41A46" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_7E4977F79AED4AE060D9CD17BBB4AB6E" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_D6E06EC978F7962CF8CFCD17BBB41A46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_676AD495F64360337936CD17BBB49CF0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_D6E06EC978F7962CF8CFCD17BBB41A46" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_676AD495F64360337936CD17BBB49CF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_7AE564DC98DD766C957ECD17BBB5EF78" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_D6E06EC978F7962CF8CFCD17BBB41A46" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_7AE564DC98DD766C957ECD17BBB5EF78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_2A135559BB521878C675CD17BBB583D5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_D6E06EC978F7962CF8CFCD17BBB41A46" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_2A135559BB521878C675CD17BBB583D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_904C007E8ECAFBB6AE9BCD17BBB51C73" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_904C007E8ECAFBB6AE9BCD17BBB51C73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D2910BC1A808BE1A34F1CD17BBB5521A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_904C007E8ECAFBB6AE9BCD17BBB51C73" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D2910BC1A808BE1A34F1CD17BBB5521A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_D15747863E2E625183E8CD17BBB5E3C9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D2910BC1A808BE1A34F1CD17BBB5521A" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_D15747863E2E625183E8CD17BBB5E3C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_0BFB1981CC55B3059297CD17BBB62B27" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D2910BC1A808BE1A34F1CD17BBB5521A" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_0BFB1981CC55B3059297CD17BBB62B27" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_6E7F27B1798D3324B54DCD17BBB6971F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_D2910BC1A808BE1A34F1CD17BBB5521A" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_6E7F27B1798D3324B54DCD17BBB6971F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1097D06EF12AFA93192ACD17BBB16199" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_7A5BFF9213D388632C24CD17BBB6C01C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_7A5BFF9213D388632C24CD17BBB6C01C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_CE8D87D17DA73E27F309CD17BBB684FA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_CE8D87D17DA73E27F309CD17BBB684FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_C3946E2C1B63D4B869B3CD17BBB7CD45" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_C3946E2C1B63D4B869B3CD17BBB7CD45" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_B4AB8F74A4F1D9DF090DCD17BBB7CB0F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_B4AB8F74A4F1D9DF090DCD17BBB7CB0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_9ED47941011FD47B1C6CCD17BBB7A3FD" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_9ED47941011FD47B1C6CCD17BBB7A3FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermInvestments" xlink:label="loc_us-gaap_OtherLongTermInvestments_C832ED118DAFA4498500CD17BBB7ABBD" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_OtherLongTermInvestments_C832ED118DAFA4498500CD17BBB7ABBD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_BC7514735D08E3958241CD17BBB76BB2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_LongTermInvestments_BC7514735D08E3958241CD17BBB76BB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialPaper" xlink:label="loc_us-gaap_CommercialPaper_AE2A72894830058A2DC7CD17BBB7E583" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_CommercialPaper_AE2A72894830058A2DC7CD17BBB7E583" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_6808F6C5DC3C2B268601CD17BBB8E6FD" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_AD84F69F675103BACF4CCD17BBB61855" xlink:to="loc_us-gaap_LongTermDebt_6808F6C5DC3C2B268601CD17BBB8E6FD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_635E08963D3DD1014C91CD17BBCC4AE7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_635E08963D3DD1014C91CD17BBCC4AE7" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_CCE42D8D522C81A56E53CD17BBCD0BD4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_CCE42D8D522C81A56E53CD17BBCD0BD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_D8E831353E4CD3C004FACD17BBCD3EF0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_CCE42D8D522C81A56E53CD17BBCD0BD4" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_D8E831353E4CD3C004FACD17BBCD3EF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_CCFD99486506B9F66ED6CD17BBCDBAB5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_D8E831353E4CD3C004FACD17BBCD3EF0" xlink:to="loc_us-gaap_SubsequentEventMember_CCFD99486506B9F66ED6CD17BBCDBAB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_F1713573DEDE4CCBF683CD17BBCD7937" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_HedgingDesignationAxis_F1713573DEDE4CCBF683CD17BBCD7937" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_FCD979F54EEB9C465F3BCD17BBCEA210" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_F1713573DEDE4CCBF683CD17BBCD7937" xlink:to="loc_us-gaap_HedgingDesignationDomain_FCD979F54EEB9C465F3BCD17BBCEA210" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_49CCD83F34A6DDFC07CFCD17BBCEF365" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_FCD979F54EEB9C465F3BCD17BBCEA210" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_49CCD83F34A6DDFC07CFCD17BBCEF365" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_127D6138E68FBB0B0B85CD17BBCE79C1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_127D6138E68FBB0B0B85CD17BBCE79C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_3FC44A92927260610469CD17BBCEF4FD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_127D6138E68FBB0B0B85CD17BBCE79C1" xlink:to="loc_us-gaap_HedgingRelationshipDomain_3FC44A92927260610469CD17BBCEF4FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashFlowHedgingMember" xlink:label="loc_us-gaap_CashFlowHedgingMember_743BFF1D0E0A667C254BCD17BBCE5E95" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_3FC44A92927260610469CD17BBCEF4FD" xlink:to="loc_us-gaap_CashFlowHedgingMember_743BFF1D0E0A667C254BCD17BBCE5E95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_0FB28E2AFE18D775F69DCD17BBCFA8B9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_DebtInstrumentAxis_0FB28E2AFE18D775F69DCD17BBCFA8B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_07DE553AD52563EA587ACD17BBCF6B88" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_0FB28E2AFE18D775F69DCD17BBCFA8B9" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_07DE553AD52563EA587ACD17BBCF6B88" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SeniorNotesDueApril2050Member" xlink:label="loc_lly_SeniorNotesDueApril2050Member_DA8BF1B0D61F5F57C848CD17BBCF5149" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_07DE553AD52563EA587ACD17BBCF6B88" xlink:to="loc_lly_SeniorNotesDueApril2050Member_DA8BF1B0D61F5F57C848CD17BBCF5149" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_70F2E8C19F098348983ECD17BBD00255" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_70F2E8C19F098348983ECD17BBD00255" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_DAE831BD3E30966AA0E7CD17BBD0DF57" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_70F2E8C19F098348983ECD17BBD00255" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_DAE831BD3E30966AA0E7CD17BBD0DF57" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ForeignCurrencyDenominatedDebtMember" xlink:label="loc_lly_ForeignCurrencyDenominatedDebtMember_93F393F2EDDE4F4C358BCD17BBD0EDDE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_DAE831BD3E30966AA0E7CD17BBD0DF57" xlink:to="loc_lly_ForeignCurrencyDenominatedDebtMember_93F393F2EDDE4F4C358BCD17BBD0EDDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeniorNotesMember" xlink:label="loc_us-gaap_SeniorNotesMember_BFB1D79061B8A41DBD28CD17BBD0A5E0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_DAE831BD3E30966AA0E7CD17BBD0DF57" xlink:to="loc_us-gaap_SeniorNotesMember_BFB1D79061B8A41DBD28CD17BBD0A5E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_C071C6085BDC5FD8B478CD17BBD08E8B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_C071C6085BDC5FD8B478CD17BBD08E8B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_C071C6085BDC5FD8B478CD17BBD08E8B" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BuyUsDollarSellEuroMember" xlink:label="loc_lly_BuyUsDollarSellEuroMember_8AB8F99CAA1F74F745FBCD17BBD1805C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_BuyUsDollarSellEuroMember_8AB8F99CAA1F74F745FBCD17BBD1805C" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BuyEuroSellUsDollarMember" xlink:label="loc_lly_BuyEuroSellUsDollarMember_CBFB19A029F52268D628CD17BBD112F0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_BuyEuroSellUsDollarMember_CBFB19A029F52268D628CD17BBD112F0" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BuyUSdollarSellJapaneseYenMember" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_904586D3B64EA96D59F4CD17BBD1E74E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_904586D3B64EA96D59F4CD17BBD1E74E" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BuyBritishPoundandSellUSDollarsMember" xlink:label="loc_lly_BuyBritishPoundandSellUSDollarsMember_38C013CB095CD8CA15F0CD17BBD13B77" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_BuyBritishPoundandSellUSDollarsMember_38C013CB095CD8CA15F0CD17BBD13B77" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SwapU.S.DollarsToEuroMember" xlink:label="loc_lly_SwapU.S.DollarsToEuroMember_816EEB6790532FEABF77CD17BBD13D65" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_SwapU.S.DollarsToEuroMember_816EEB6790532FEABF77CD17BBD13D65" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SwapSwissFrancsToU.S.DollarsMember" xlink:label="loc_lly_SwapSwissFrancsToU.S.DollarsMember_6B0338DA75C77515D8FECD17BBD22392" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_SwapSwissFrancsToU.S.DollarsMember_6B0338DA75C77515D8FECD17BBD22392" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_SwapU.S.DollarsToBritishPoundsMember" xlink:label="loc_lly_SwapU.S.DollarsToBritishPoundsMember_320C8A872AF11C989028CD17BBD2378F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_lly_SwapU.S.DollarsToBritishPoundsMember_320C8A872AF11C989028CD17BBD2378F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_39F90583CC2AEE70A194CD17BBD281BB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1FC886A0D88F7A8FBC8ECD17BBD16031" xlink:to="loc_us-gaap_InterestRateSwapMember_39F90583CC2AEE70A194CD17BBD281BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E436AEC978B6811F1AE8CD17BBCCF376" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_98F0E36A61E69CCD3D75CD17BBD2E4BC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_98F0E36A61E69CCD3D75CD17BBD2E4BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_E3489EA0FA106685F89FCD17BBD38501" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_E3489EA0FA106685F89FCD17BBD38501" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_37D245AA81888BD1CC21CD17BBD35E66" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_37D245AA81888BD1CC21CD17BBD35E66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_78422CDE485085A21DA5CD17BBD3C6ED" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_LongTermDebt_78422CDE485085A21DA5CD17BBD3C6ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax" xlink:label="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_A0971E6C10BF8DEBA883CD17BBD35305" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_A0971E6C10BF8DEBA883CD17BBD35305" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="loc_us-gaap_DerivativeNotionalAmount_1C325B26BF3AA3D560F4CD17BBD307F8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_DerivativeNotionalAmount_1C325B26BF3AA3D560F4CD17BBD307F8" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DescriptionOfDerivativeActivityVolumePercent" xlink:label="loc_lly_DescriptionOfDerivativeActivityVolumePercent_E3F86B94F28C3087EFD1CD17BBD314E9" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_lly_DescriptionOfDerivativeActivityVolumePercent_E3F86B94F28C3087EFD1CD17BBD314E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_F4410C5A44C6595E7B93CD17BBD49844" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_F4410C5A44C6595E7B93CD17BBD49844" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_EDF21FFAC80D608A1EB7CD17BBD4AB2D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_EDF21FFAC80D608A1EB7CD17BBD4AB2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_16C86B08C27FB7945E72CD17BBD4FE19" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_16C86B08C27FB7945E72CD17BBD4FE19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_77642A3BECC26B2C959BCD17BBD4C090" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_77642A3BECC26B2C959BCD17BBD4C090" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_662ACD2497E26E6A0B31CD17BBD4422B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_ImpairmentOfInvestments_662ACD2497E26E6A0B31CD17BBD4422B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_9783A988F2A82F323BD1CD17BBD499A8" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_9783A988F2A82F323BD1CD17BBD499A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized" xlink:label="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_DFD18C990312E6110A0BCD17BBD52720" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_07DAAA9842E04DA9E5AFCD17BBD2381D" xlink:to="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_DFD18C990312E6110A0BCD17BBD52720" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_3A05B2FA679AF0CEDE48CD17BBDF0F23" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_30C21DCFA1FC2AC33616CD17BBDFFFC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_3A05B2FA679AF0CEDE48CD17BBDF0F23" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_30C21DCFA1FC2AC33616CD17BBDFFFC7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsRealizedGainsAndLossesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_F7A06E333FEE9BE81867CD17BB8C9BDD" xlink:type="locator" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ProceedsfromSaleofEquityandAvailableforSaleSecurities" xlink:label="loc_lly_ProceedsfromSaleofEquityandAvailableforSaleSecurities_0341A06BEB0669BEE92DCD17BB8CABFC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_F7A06E333FEE9BE81867CD17BB8C9BDD" xlink:to="loc_lly_ProceedsfromSaleofEquityandAvailableforSaleSecurities_0341A06BEB0669BEE92DCD17BB8CABFC" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AvailableforSaleSecuritiesandEquitySecuritiesFVNIRealizedGain" xlink:label="loc_lly_AvailableforSaleSecuritiesandEquitySecuritiesFVNIRealizedGain_BCB29948168CC0BBA256CD17BB8DA816" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_F7A06E333FEE9BE81867CD17BB8C9BDD" xlink:to="loc_lly_AvailableforSaleSecuritiesandEquitySecuritiesFVNIRealizedGain_BCB29948168CC0BBA256CD17BB8DA816" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AvailableforsaleSecuritiesandEquitySecuritiesFVNIRealizedLoss" xlink:label="loc_lly_AvailableforsaleSecuritiesandEquitySecuritiesFVNIRealizedLoss_4DD333EBBA498F1CAA8BCD17BB8D4813" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_F7A06E333FEE9BE81867CD17BB8C9BDD" xlink:to="loc_lly_AvailableforsaleSecuritiesandEquitySecuritiesFVNIRealizedLoss_4DD333EBBA498F1CAA8BCD17BB8D4813" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsRiskManagementInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_170DBA3A931B600DA9A9CD17BBA3EF76" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_170DBA3A931B600DA9A9CD17BBA3EF76" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_C8C5E37462A905A9C08FCD17BBA41A2F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_C8C5E37462A905A9C08FCD17BBA41A2F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_9F11DFE973F65A0C9C1ECD17BBA45595" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_C8C5E37462A905A9C08FCD17BBA41A2F" xlink:to="loc_us-gaap_HedgingRelationshipDomain_9F11DFE973F65A0C9C1ECD17BBA45595" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueHedgingMember" xlink:label="loc_us-gaap_FairValueHedgingMember_B3CA851396EAB41A909CCD17BBA49FA4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_9F11DFE973F65A0C9C1ECD17BBA45595" xlink:to="loc_us-gaap_FairValueHedgingMember_B3CA851396EAB41A909CCD17BBA49FA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashFlowHedgingMember" xlink:label="loc_us-gaap_CashFlowHedgingMember_486BE5EE29E90A9B0A94CD17BBA4031C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_9F11DFE973F65A0C9C1ECD17BBA45595" xlink:to="loc_us-gaap_CashFlowHedgingMember_486BE5EE29E90A9B0A94CD17BBA4031C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetInvestmentHedgingMember" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_5DB9F935F86C97105981CD17BBA41C85" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingRelationshipDomain_9F11DFE973F65A0C9C1ECD17BBA45595" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_5DB9F935F86C97105981CD17BBA41C85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_452E9E431AFDCAEACE31CD17BBA5979E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_452E9E431AFDCAEACE31CD17BBA5979E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_AC79854C3AEB029519C4CD17BBA59090" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_452E9E431AFDCAEACE31CD17BBA5979E" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_AC79854C3AEB029519C4CD17BBA59090" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_4F650F2ED7A720A58360CD17BBA5BE49" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_AC79854C3AEB029519C4CD17BBA59090" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_4F650F2ED7A720A58360CD17BBA5BE49" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_4DD6A211EBDB76076086CD17BBA5CC1A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_4F650F2ED7A720A58360CD17BBA5BE49" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_4DD6A211EBDB76076086CD17BBA5CC1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_66D167F57034422A4FD0CD17BBA6EE62" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_4F650F2ED7A720A58360CD17BBA5BE49" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_66D167F57034422A4FD0CD17BBA6EE62" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_58F1EC06A6A04CC25D11CD17BBA6F4E6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_58F1EC06A6A04CC25D11CD17BBA6F4E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F13C3962B29B7FBF456ECD17BBA6B612" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_58F1EC06A6A04CC25D11CD17BBA6F4E6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F13C3962B29B7FBF456ECD17BBA6B612" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_FF261696316E5F77294ACD17BBA6637C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F13C3962B29B7FBF456ECD17BBA6B612" xlink:to="loc_us-gaap_InterestRateContractMember_FF261696316E5F77294ACD17BBA6637C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_FB00A866983B84308485CD17BBA6DB28" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F13C3962B29B7FBF456ECD17BBA6B612" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_FB00A866983B84308485CD17BBA6DB28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_8CD025A886EE9A942F67CD17BBA74DE7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F13C3962B29B7FBF456ECD17BBA6B612" xlink:to="loc_us-gaap_ForeignExchangeContractMember_8CD025A886EE9A942F67CD17BBA74DE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_FAEF9662AB429167C0A1CD17BBA77413" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_HedgingDesignationAxis_FAEF9662AB429167C0A1CD17BBA77413" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_9CC3D76DBDA1450C372FCD17BBA7F80C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_FAEF9662AB429167C0A1CD17BBA77413" xlink:to="loc_us-gaap_HedgingDesignationDomain_9CC3D76DBDA1450C372FCD17BBA7F80C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2498D8AB63444471E1E8CD17BBA7DAFB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_9CC3D76DBDA1450C372FCD17BBA7F80C" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2498D8AB63444471E1E8CD17BBA7DAFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_600C1AE1DEDE6F59C086CD17BBA74615" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_9CC3D76DBDA1450C372FCD17BBA7F80C" xlink:to="loc_us-gaap_NondesignatedMember_600C1AE1DEDE6F59C086CD17BBA74615" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_6D56A2838AAE8E24B99BCD17BBA85040" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_6D56A2838AAE8E24B99BCD17BBA85040" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8A014BA75B8992704826CD17BBA89888" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_6D56A2838AAE8E24B99BCD17BBA85040" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8A014BA75B8992704826CD17BBA89888" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_6FEB9D13D3F7A43999C2CD17BBA87946" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8A014BA75B8992704826CD17BBA89888" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_6FEB9D13D3F7A43999C2CD17BBA87946" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_50210B4203F3BA2B2A04CD17BBA89EF8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8A014BA75B8992704826CD17BBA89888" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_50210B4203F3BA2B2A04CD17BBA89EF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_12E338320E317AAD0E52CD17BBA88549" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8A014BA75B8992704826CD17BBA89888" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_12E338320E317AAD0E52CD17BBA88549" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_AC46A7B44EBBBC8DC39DCD17BBA35164" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetsNoncurrent" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_EC8015B074B340341115CD17BBA98ADD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_EC8015B074B340341115CD17BBA98ADD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetsCurrent" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_D895841884D741DE0D88CD17BBA9EA98" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_D895841884D741DE0D88CD17BBA9EA98" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_23AD5457BD06CF144E48CD17BBA92E60" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_23AD5457BD06CF144E48CD17BBA92E60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_A61FAD900C0CE56461F5CD17BBA9DC87" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_46CA1C9879DA81D7DAC7CD17BBA9123E" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_A61FAD900C0CE56461F5CD17BBA9DC87" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock_107E4E741086F77ABB28CD17BBDB0CA4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock_107E4E741086F77ABB28CD17BBDB0CA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfNetInvestmentHedgesInAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNetInvestmentHedgesInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_DB3617C397159AD4FC8CCD17BBDB6EE8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_ScheduleOfNetInvestmentHedgesInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_DB3617C397159AD4FC8CCD17BBDB6EE8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_3ED6EDF6D841E916170DCD17BBDBE51C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_3ED6EDF6D841E916170DCD17BBDBE51C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_07B4BF26C16E4408B14ECD17BBDB87D4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_07B4BF26C16E4408B14ECD17BBDB87D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_6A477D6AA054AD9FDB92CD17BBDBA874" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_6A477D6AA054AD9FDB92CD17BBDBA874" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_EC5AC765D40A411C8673CD17BBDBEFA7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_EC5AC765D40A411C8673CD17BBDBEFA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_55A00ACFE92BF558B56DCD17BBDCB50C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_55A00ACFE92BF558B56DCD17BBDCB50C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock_C10EFBE8CC09B325A520CD17BBDCAE6E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock_C10EFBE8CC09B325A520CD17BBDCAE6E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnInvestmentsTextBlock" xlink:label="loc_us-gaap_GainLossOnInvestmentsTextBlock_2C40EF1B8DFE87E0D5A5CD17BBDC579F" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01F70CFC381DB05FA050CD17BBDAFF43" xlink:to="loc_us-gaap_GainLossOnInvestmentsTextBlock_2C40EF1B8DFE87E0D5A5CD17BBDC579F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsUnrealizedGainsAndLossesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_A4BF69337A6218729AECCD17BB958D14" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_2CD0DBE4BBB771283D62CD17BB952E3E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_A4BF69337A6218729AECCD17BB958D14" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_2CD0DBE4BBB771283D62CD17BB952E3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_7549B5FC8B52B1FCA684CD17BB954B44" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_A4BF69337A6218729AECCD17BB958D14" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_7549B5FC8B52B1FCA684CD17BB954B44" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DebtSecuritiesAvailableforsaleUnrealizedGainPosition" xlink:label="loc_lly_DebtSecuritiesAvailableforsaleUnrealizedGainPosition_DA3918887D34CA56AF61CD17BB954F3B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_A4BF69337A6218729AECCD17BB958D14" xlink:to="loc_lly_DebtSecuritiesAvailableforsaleUnrealizedGainPosition_DA3918887D34CA56AF61CD17BB954F3B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_EC06C7ABE9528F4C12B9CD17BB955694" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_A4BF69337A6218729AECCD17BB958D14" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_EC06C7ABE9528F4C12B9CD17BB955694" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_0940B9C2764E01A29F34CD17BB35F762" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_FD658A084AA9FEFB5676CD17BB352215" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_0940B9C2764E01A29F34CD17BB35F762" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_FD658A084AA9FEFB5676CD17BB352215" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_673B566F3FCC82D4D705CD17BB2D6769" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_16DB8AE861469BDA0CB2CD17BB2E1526" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_673B566F3FCC82D4D705CD17BB2D6769" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_16DB8AE861469BDA0CB2CD17BB2E1526" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_4F8DB3378497B4CDDEC0CD17BACD681A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_1A25DB74DFF2B9BA3542CD17BACEBCA3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_4F8DB3378497B4CDDEC0CD17BACD681A" xlink:to="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_1A25DB74DFF2B9BA3542CD17BACEBCA3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossAociDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_9984F0FF726242A90E2ACD17BAB8F58E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_D57ED28FAE5E799EFF48CD17BAB96801" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_9984F0FF726242A90E2ACD17BAB8F58E" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_D57ED28FAE5E799EFF48CD17BAB96801" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_B5E7D82F30EFC203F774CD17BAB90AAF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_D57ED28FAE5E799EFF48CD17BAB96801" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_B5E7D82F30EFC203F774CD17BAB90AAF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_576FB311D0FB3460B2DDCD17BAB964A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_B5E7D82F30EFC203F774CD17BAB90AAF" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_576FB311D0FB3460B2DDCD17BAB964A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentContinuingOperationsMember" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_E9A2CE80D58C7D6EFACACD17BAB988B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_576FB311D0FB3460B2DDCD17BAB964A6" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_E9A2CE80D58C7D6EFACACD17BAB988B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDiscontinuedOperationsMember" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_19B802211C9065146936CD17BABAD862" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_576FB311D0FB3460B2DDCD17BAB964A6" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_19B802211C9065146936CD17BABAD862" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_E5C2604EF2F4A2685CFACD17BABA0DFA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_D57ED28FAE5E799EFF48CD17BAB96801" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_E5C2604EF2F4A2685CFACD17BABA0DFA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D27AFDFE82B6C62FB228CD17BABA044B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_E5C2604EF2F4A2685CFACD17BABA0DFA" xlink:to="loc_us-gaap_EquityComponentDomain_D27AFDFE82B6C62FB228CD17BABA044B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_D27AFDFE82B6C62FB228CD17BABA044B" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_5D22DD1A1E4BC3BA2A90CD17BABBACCB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_5D22DD1A1E4BC3BA2A90CD17BABBACCB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_AC90FA3A1A131E2DAE8DCD17BABB881A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_AC90FA3A1A131E2DAE8DCD17BABB881A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_839B400A31138874268ECD17BABB29DE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_839B400A31138874268ECD17BABB29DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_293D779E543C05B9B8E6CD17BABB9CC8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_293D779E543C05B9B8E6CD17BABB9CC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C390CF1939CBE8760997CD17BABB226C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_C390CF1939CBE8760997CD17BABB226C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AociAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_C0FBAB64BD3A5E3BCE89CD17BABC1064" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_F8301E5AD2D76ECE7434CD17BABA95F3" xlink:to="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_C0FBAB64BD3A5E3BCE89CD17BABC1064" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_AA4F57DCE6798850BA05CD17BABC5B60" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_D57ED28FAE5E799EFF48CD17BAB96801" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_AA4F57DCE6798850BA05CD17BABC5B60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_AA4F57DCE6798850BA05CD17BABC5B60" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_C6A3E507F10C7CCDF965CD17BABCA5A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_C6A3E507F10C7CCDF965CD17BABCA5A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_67E7574DDDFDB125C1D2CD17BABCD362" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_67E7574DDDFDB125C1D2CD17BABCD362" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BDB0C5E8E18AA4B7150CD17BABDFD89" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_7BDB0C5E8E18AA4B7150CD17BABDFD89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_4DA47306F1BDD0C8877FCD17BABDFDE9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_4DA47306F1BDD0C8877FCD17BABDFDE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2C0819960979EE029433CD17BABD2E51" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_B6125E37F2B8D76316E8CD17BABC43A0" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2C0819960979EE029433CD17BABD2E51" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_C52DFD1EAC3BA0DA4F11CD17BA9459C7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_95197F92DBAD031F86E1CD17BA94CC9D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_C52DFD1EAC3BA0DA4F11CD17BA9459C7" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_95197F92DBAD031F86E1CD17BA94CC9D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_AD5617E9B27E0D91ED02CD17BA9568C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_95197F92DBAD031F86E1CD17BA94CC9D" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_AD5617E9B27E0D91ED02CD17BA9568C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_456AFBB9A19891076234CD17BA9516C8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_AD5617E9B27E0D91ED02CD17BA9568C6" xlink:to="loc_us-gaap_EquityComponentDomain_456AFBB9A19891076234CD17BA9516C8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_C9DEDAF5A55ABAD5159BCD17BA954830" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/netLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_456AFBB9A19891076234CD17BA9516C8" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_C9DEDAF5A55ABAD5159BCD17BA954830" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_488D4077447571B3CCBACD17BA96CCB3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_C9DEDAF5A55ABAD5159BCD17BA954830" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_488D4077447571B3CCBACD17BA96CCB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_70D620AC3F403D035001CD17BA96E4A9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_C9DEDAF5A55ABAD5159BCD17BA954830" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_70D620AC3F403D035001CD17BA96E4A9" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember" xlink:label="loc_lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember_B312672D589C2D20E862CD17BA96389F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_456AFBB9A19891076234CD17BA9516C8" xlink:to="loc_lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember_B312672D589C2D20E862CD17BA96389F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1A24BD09B20CD7EE77E0CD17BA9681EC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_95197F92DBAD031F86E1CD17BA94CC9D" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1A24BD09B20CD7EE77E0CD17BA9681EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_A9AD87EC9806FF6DB1EFCD17BA962077" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1A24BD09B20CD7EE77E0CD17BA9681EC" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_A9AD87EC9806FF6DB1EFCD17BA962077" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_80091585EF7EBD9E1429CD17BA972873" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_A9AD87EC9806FF6DB1EFCD17BA962077" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_80091585EF7EBD9E1429CD17BA972873" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_95197F92DBAD031F86E1CD17BA94CC9D" xlink:to="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_74B0AC6493CEBB81C664CD17BA971F25" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_74B0AC6493CEBB81C664CD17BA971F25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BFA506D6A520C2772EEFCD17BA97F609" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BFA506D6A520C2772EEFCD17BA97F609" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4B61C3D08A6017BBA206CD17BA98795C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/netLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4B61C3D08A6017BBA206CD17BA98795C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_E0AD479245B39ED4D436CD17BA98DF00" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_E0AD479245B39ED4D436CD17BA98DF00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_1D29D1141C7DABFB741ACD17BA98CEE7" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_1D29D1141C7DABFB741ACD17BA98CEE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_F9464583537FE7DA657FCD17BA984412" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6AFF88BDB06CC6E947EBCD17BA97DF90" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_F9464583537FE7DA657FCD17BA984412" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_6D68BAE5FFE13199A42DCD17BAC60BF1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5B14E04E1F8ED648FA43CD17BAC6C7BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_6D68BAE5FFE13199A42DCD17BAC60BF1" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5B14E04E1F8ED648FA43CD17BAC6C7BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock_9A2B5503E77A4789C420CD17BAC6DC73" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_6D68BAE5FFE13199A42DCD17BAC60BF1" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock_9A2B5503E77A4789C420CD17BAC6DC73" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_DC808A163AFE7433D063CD17BAA18EEA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_A30E40302C7495019B7ACD17BAA1462C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_DC808A163AFE7433D063CD17BAA18EEA" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_A30E40302C7495019B7ACD17BAA1462C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_6ED16862466166ACEDA5CD17BAA2CAF6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_A30E40302C7495019B7ACD17BAA1462C" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_6ED16862466166ACEDA5CD17BAA2CAF6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_6ED16862466166ACEDA5CD17BAA2CAF6" xlink:to="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_EA46340E748BCE4F933CCD17BAA29539" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_EA46340E748BCE4F933CCD17BAA29539" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_2F249A0B03D7E6EDBABBCD17BAA31193" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_2F249A0B03D7E6EDBABBCD17BAA31193" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_703116DC710B1AA30949CD17BAA3BEC7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_703116DC710B1AA30949CD17BAA3BEC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_AAE2EA9A8310554578D9CD17BAA81440" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_811F2DE86F2DE1B7A47ECD17BAA2B815" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_AAE2EA9A8310554578D9CD17BAA81440" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_FE6BD75EC3B7E44C8AC7CD17BAA8FEF6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_A30E40302C7495019B7ACD17BAA1462C" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_FE6BD75EC3B7E44C8AC7CD17BAA8FEF6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_0BA788F483D80129096FCD17BAA89324" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_FE6BD75EC3B7E44C8AC7CD17BAA8FEF6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_0BA788F483D80129096FCD17BAA89324" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OthernetIncomeExpense" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_1A64CF2B9DDFBD820211CD17BA845565" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock" xlink:label="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_7F69E18DC82DC3692806CD17BA85A2D2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_1A64CF2B9DDFBD820211CD17BA845565" xlink:to="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_7F69E18DC82DC3692806CD17BA85A2D2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OthernetIncomeExpenseDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_EE92B3B40BA5466284B3CD17BA741B5C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:to="loc_us-gaap_InterestExpense_EE92B3B40BA5466284B3CD17BA741B5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_A06490AD8F05ED8FFF34CD17BA752AF7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:to="loc_us-gaap_InvestmentIncomeInterest_A06490AD8F05ED8FFF34CD17BA752AF7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent" xlink:label="loc_us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent_11908689C18BFB81500ECD17BA760D8F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:to="loc_us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent_11908689C18BFB81500ECD17BA760D8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_34C06322655B7C095464CD17BA76CD19" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_34C06322655B7C095464CD17BA76CD19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_5A89C293C48251FCF3E0CD17BA76888C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C993AA0C309CCD5956E4CD17BA745386" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_5A89C293C48251FCF3E0CD17BA76888C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/OthernetIncomeExpenseTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_BA3AD359D4C6DB4440ABCD17BA7D1D08" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock_C51EA10AA92C3D730CA5CD17BA7DF928" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_BA3AD359D4C6DB4440ABCD17BA7D1D08" xlink:to="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock_C51EA10AA92C3D730CA5CD17BA7DF928" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefits" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_4B67E691EDABE53EE321CD17BB1D69D4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_C656C56F13F4195C3B1DCD17BB1D8546" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_4B67E691EDABE53EE321CD17BB1D69D4" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_C656C56F13F4195C3B1DCD17BB1D8546" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsComponentsOfNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_C3950AEE90957A04282ECD17BB0AD7DA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_CA9DDC1165FBB01B9B3BCD17BB0A6486" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_C3950AEE90957A04282ECD17BB0AD7DA" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_CA9DDC1165FBB01B9B3BCD17BB0A6486" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_E7903E8CD094650EE6C3CD17BB0B0F7F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_CA9DDC1165FBB01B9B3BCD17BB0A6486" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_E7903E8CD094650EE6C3CD17BB0B0F7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_6D6E7853D605FB437A07CD17BB0B25BC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_E7903E8CD094650EE6C3CD17BB0B0F7F" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_6D6E7853D605FB437A07CD17BB0B25BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_85D00B9E6FF8F7F0F121CD17BB0B3ED1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_6D6E7853D605FB437A07CD17BB0B25BC" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_85D00B9E6FF8F7F0F121CD17BB0B3ED1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_B2C922C00DBA8F85F187CD17BB0CEFFD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_6D6E7853D605FB437A07CD17BB0B25BC" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_B2C922C00DBA8F85F187CD17BB0CEFFD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_CA9DDC1165FBB01B9B3BCD17BB0A6486" xlink:to="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_6C49D4155EF85D44A8EFCD17BB11799E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_6C49D4155EF85D44A8EFCD17BB11799E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_A5BE242598CA2B54F973CD17BB11FCB5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_A5BE242598CA2B54F973CD17BB11FCB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_8BA47AD1295BE824870DCD17BB12C9DA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_8BA47AD1295BE824870DCD17BB12C9DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_0C70D457E6CDE4DF2AB6CD17BB1260BC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_0C70D457E6CDE4DF2AB6CD17BB1260BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLossImmediateRecognitionAsComponentInNetPeriodicBenefitCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLossImmediateRecognitionAsComponentInNetPeriodicBenefitCostCredit_D16051B350BEA805B7F4CD17BB122554" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLossImmediateRecognitionAsComponentInNetPeriodicBenefitCostCredit_D16051B350BEA805B7F4CD17BB122554" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_DF05E1C9FBA9413186DBCD17BB125C22" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_FC8D0835B6CD7131EF9ACD17BB1156B8" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_DF05E1C9FBA9413186DBCD17BB125C22" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_52035B2041DF45EC0A50CD17BAF92304" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_E118A047E7AD3F77025ACD17BAF9E1EB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_52035B2041DF45EC0A50CD17BAF92304" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_E118A047E7AD3F77025ACD17BAF9E1EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_1D15DD46987F54CCF0A6CD17BAF9466E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_E118A047E7AD3F77025ACD17BAF9E1EB" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_1D15DD46987F54CCF0A6CD17BAF9466E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6B031427F082E49F4180CD17BAFF791F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1D15DD46987F54CCF0A6CD17BAF9466E" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6B031427F082E49F4180CD17BAFF791F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_EE4CF597349843FB6C24CD17BAFFFD67" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_6B031427F082E49F4180CD17BAFF791F" xlink:to="loc_us-gaap_SubsequentEventMember_EE4CF597349843FB6C24CD17BAFFFD67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_E118A047E7AD3F77025ACD17BAF9E1EB" xlink:to="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionContributions" xlink:label="loc_us-gaap_PensionContributions_FB9B8B90633966343ED4CD17BAFF7487" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:to="loc_us-gaap_PensionContributions_FB9B8B90633966343ED4CD17BAFF7487" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_PaymentforPensionBenefitsAdditionalDiscretionaryFunding" xlink:label="loc_lly_PaymentforPensionBenefitsAdditionalDiscretionaryFunding_B323B882F3E19AB3E21BCD17BB006313" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:to="loc_lly_PaymentforPensionBenefitsAdditionalDiscretionaryFunding_B323B882F3E19AB3E21BCD17BB006313" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount" xlink:label="loc_us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount_7F4F181053CDBEEC3A00CD17BB0017B3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:to="loc_us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount_7F4F181053CDBEEC3A00CD17BB0017B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear_A097BDF779BA5078807ECD17BB00F26D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_5A4974128FF13D5E507FCD17BAFFF42B" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear_A097BDF779BA5078807ECD17BB00F26D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_24B2CEFEC06B7022A3A3CD17BB1527A6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfNetBenefitCostsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_0EA5746FD83BA713F4F2CD17BB15525B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_24B2CEFEC06B7022A3A3CD17BB1527A6" xlink:to="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_0EA5746FD83BA713F4F2CD17BB15525B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/Revenue" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_9B0D1557302A011D760ECD17BC8CF55D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_55BFA685369A78E26C1BCD17BC8C9BDA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_9B0D1557302A011D760ECD17BC8CF55D" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_55BFA685369A78E26C1BCD17BC8C9BDA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueContractLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_90C29C27A92E33C13BF3CD17BC7E8512" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_A9EACE379956F115F7C4CD17BC7ED2F5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_90C29C27A92E33C13BF3CD17BC7E8512" xlink:to="loc_us-gaap_ContractWithCustomerLiability_A9EACE379956F115F7C4CD17BC7ED2F5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_A606C0D3392C2A91F244CD17BC6812E0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_6ADB4CF53D35FA5D27CACD17BC686081" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_A606C0D3392C2A91F244CD17BC6812E0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_6ADB4CF53D35FA5D27CACD17BC686081" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_1F289C84A106AABBA1E1CD17BC693EF5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_6ADB4CF53D35FA5D27CACD17BC686081" xlink:to="loc_srt_StatementGeographicalAxis_1F289C84A106AABBA1E1CD17BC693EF5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_1F289C84A106AABBA1E1CD17BC693EF5" xlink:to="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_DC8912E3973D155D6091CD17BC69FFB2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:to="loc_country_US_DC8912E3973D155D6091CD17BC69FFB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_EuropeMember" xlink:label="loc_srt_EuropeMember_4E5607BE6220366D7724CD17BC69F612" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:to="loc_srt_EuropeMember_4E5607BE6220366D7724CD17BC69F612" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_JP" xlink:label="loc_country_JP_A5F440DCCFF2533B1CF3CD17BC6AB592" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:to="loc_country_JP_A5F440DCCFF2533B1CF3CD17BC6AB592" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_CN" xlink:label="loc_country_CN_24A627BF4285B46D6205CD17BC6A9761" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:to="loc_country_CN_24A627BF4285B46D6205CD17BC6A9761" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherForeignCountriesMember" xlink:label="loc_lly_OtherForeignCountriesMember_890C669D2B248CE16854CD17BC6AA045" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_58B14876E703B09F48F7CD17BC698603" xlink:to="loc_lly_OtherForeignCountriesMember_890C669D2B248CE16854CD17BC6AA045" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_97CAFE77E0C9EFAC7BBECD17BC6AB1C4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_6ADB4CF53D35FA5D27CACD17BC686081" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_97CAFE77E0C9EFAC7BBECD17BC6AB1C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_83CECA2C25ED3CD8DD1ECD17BC6A2AF2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_97CAFE77E0C9EFAC7BBECD17BC6AB1C4" xlink:to="loc_us-gaap_Revenues_83CECA2C25ED3CD8DD1ECD17BC6A2AF2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByProductDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_E054ABBC33A558D4CB2FCD17BC719610" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_38037C7AE286158B04B5CD17BC71A35C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_E054ABBC33A558D4CB2FCD17BC719610" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_38037C7AE286158B04B5CD17BC71A35C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_C2E9CE85BE721AB1BE47CD17BC7106CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_38037C7AE286158B04B5CD17BC71A35C" xlink:to="loc_srt_ProductOrServiceAxis_C2E9CE85BE721AB1BE47CD17BC7106CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_C2E9CE85BE721AB1BE47CD17BC7106CA" xlink:to="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_DiabetesMember" xlink:label="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:to="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_TrulicityMemberMember" xlink:label="loc_lly_TrulicityMemberMember_48C631272B273BDF4246CD17BC72ED14" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_TrulicityMemberMember_48C631272B273BDF4246CD17BC72ED14" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_HumalogMember" xlink:label="loc_lly_HumalogMember_4360DE7BB75BC006724FCD17BC73A699" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_HumalogMember_4360DE7BB75BC006724FCD17BC73A699" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_HumulinMember" xlink:label="loc_lly_HumulinMember_4475E73416A9FC604707CD17BC731E8E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_HumulinMember_4475E73416A9FC604707CD17BC731E8E" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_0922A6F9ABC2C29E6B97CD17BC73EF3E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_BasaglarMember_0922A6F9ABC2C29E6B97CD17BC73EF3E" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_28446114F82BDD57C54CCD17BC73C962" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_JardianceMember_28446114F82BDD57C54CCD17BC73C962" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_EB6690FAE827C397BA2CCD17BC73BAF6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_TrajentaBIMember_EB6690FAE827C397BA2CCD17BC73BAF6" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherDiabetesMember" xlink:label="loc_lly_OtherDiabetesMember_36F3A440D63FE3286FACCD17BC733210" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DiabetesMember_EB947D7018317BD85F2DCD17BC722F97" xlink:to="loc_lly_OtherDiabetesMember_36F3A440D63FE3286FACCD17BC733210" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OncologyMember" xlink:label="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:to="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_AlimtaMember" xlink:label="loc_lly_AlimtaMember_DD5F55F068B021FA830DCD17BC74DE66" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:to="loc_lly_AlimtaMember_DD5F55F068B021FA830DCD17BC74DE66" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CyramzaMember" xlink:label="loc_lly_CyramzaMember_C0CDD98D8BC139FFDEEECD17BC7417AA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:to="loc_lly_CyramzaMember_C0CDD98D8BC139FFDEEECD17BC7417AA" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_VerzenioMember" xlink:label="loc_lly_VerzenioMember_52CCE2883849125FA9ADCD17BC747200" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:to="loc_lly_VerzenioMember_52CCE2883849125FA9ADCD17BC747200" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_45DA9ADDEAD17B85768CCD17BC743430" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:to="loc_lly_ErbituxMember_45DA9ADDEAD17B85768CCD17BC743430" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherOncologyMember" xlink:label="loc_lly_OtherOncologyMember_C915F318F6278CF7A447CD17BC75A22B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OncologyMember_3A9BA6B512793B59C72FCD17BC74A9A6" xlink:to="loc_lly_OtherOncologyMember_C915F318F6278CF7A447CD17BC75A22B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ImmunologyMember" xlink:label="loc_lly_ImmunologyMember_BD32BF6AE6F02FC7EAF5CD17BC75ACD9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:to="loc_lly_ImmunologyMember_BD32BF6AE6F02FC7EAF5CD17BC75ACD9" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_TaltzMember" xlink:label="loc_lly_TaltzMember_6C4849F67C0AB7872C53CD17BC757A5E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_ImmunologyMember_BD32BF6AE6F02FC7EAF5CD17BC75ACD9" xlink:to="loc_lly_TaltzMember_6C4849F67C0AB7872C53CD17BC757A5E" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OlumiantMember" xlink:label="loc_lly_OlumiantMember_086E7073ACEC119AFE7ACD17BC75B69A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_ImmunologyMember_BD32BF6AE6F02FC7EAF5CD17BC75ACD9" xlink:to="loc_lly_OlumiantMember_086E7073ACEC119AFE7ACD17BC75B69A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherImmunologyMember" xlink:label="loc_lly_OtherImmunologyMember_0710DA690A90B591EFB0CD17BC75F355" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_ImmunologyMember_BD32BF6AE6F02FC7EAF5CD17BC75ACD9" xlink:to="loc_lly_OtherImmunologyMember_0710DA690A90B591EFB0CD17BC75F355" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_NeuroscienceMember" xlink:label="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:to="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_E5B45F3C034AF5D526BCCD17BC76528B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:to="loc_lly_CymbaltaMember_E5B45F3C034AF5D526BCCD17BC76528B" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ZyprexaMember" xlink:label="loc_lly_ZyprexaMember_A7ACDA102E3D744F00A3CD17BC76F858" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:to="loc_lly_ZyprexaMember_A7ACDA102E3D744F00A3CD17BC76F858" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_EmgalityMember" xlink:label="loc_lly_EmgalityMember_1D5DF722BB8F438E2AF1CD17BC76F11D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:to="loc_lly_EmgalityMember_1D5DF722BB8F438E2AF1CD17BC76F11D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherNeuroscienceMember" xlink:label="loc_lly_OtherNeuroscienceMember_B2925050A67BEC102687CD17BC766BDD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_NeuroscienceMember_034149C8768EF738A93BCD17BC76A3EF" xlink:to="loc_lly_OtherNeuroscienceMember_B2925050A67BEC102687CD17BC766BDD" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherProductTotalMember" xlink:label="loc_lly_OtherProductTotalMember_6ACF91CDC008E9CB6B5ECD17BC77EFE5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0480C621BC5B416A21CFCD17BC72970A" xlink:to="loc_lly_OtherProductTotalMember_6ACF91CDC008E9CB6B5ECD17BC77EFE5" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_ForteoMember" xlink:label="loc_lly_ForteoMember_F2E8D8D3CE39A6FEF01CCD17BC77306D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OtherProductTotalMember_6ACF91CDC008E9CB6B5ECD17BC77EFE5" xlink:to="loc_lly_ForteoMember_F2E8D8D3CE39A6FEF01CCD17BC77306D" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CialisMember" xlink:label="loc_lly_CialisMember_EB67285F40D9C7F53B00CD17BC77642A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OtherProductTotalMember_6ACF91CDC008E9CB6B5ECD17BC77EFE5" xlink:to="loc_lly_CialisMember_EB67285F40D9C7F53B00CD17BC77642A" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_OtherProductMember" xlink:label="loc_lly_OtherProductMember_B9135A1F96200085AE32CD17BC77ABFF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_OtherProductTotalMember_6ACF91CDC008E9CB6B5ECD17BC77EFE5" xlink:to="loc_lly_OtherProductMember_B9135A1F96200085AE32CD17BC77ABFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_B372CE88CA1335A7D6F6CD17BC771E97" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_38037C7AE286158B04B5CD17BC71A35C" xlink:to="loc_srt_StatementGeographicalAxis_B372CE88CA1335A7D6F6CD17BC771E97" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_AFCA78E80BFDC573108DCD17BC78BDBB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_B372CE88CA1335A7D6F6CD17BC771E97" xlink:to="loc_srt_SegmentGeographicalDomain_AFCA78E80BFDC573108DCD17BC78BDBB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_D3647D5F344777F035C6CD17BC784D69" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_AFCA78E80BFDC573108DCD17BC78BDBB" xlink:to="loc_country_US_D3647D5F344777F035C6CD17BC784D69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonUsMember" xlink:label="loc_us-gaap_NonUsMember_C311E544C42588DE2EF6CD17BC7820AC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_AFCA78E80BFDC573108DCD17BC78BDBB" xlink:to="loc_us-gaap_NonUsMember_C311E544C42588DE2EF6CD17BC7820AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_699DE48D600101C3ADD2CD17BC78D3A1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_38037C7AE286158B04B5CD17BC71A35C" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_699DE48D600101C3ADD2CD17BC78D3A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_848CDAEBFDCC47777B25CD17BC780E97" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_699DE48D600101C3ADD2CD17BC78D3A1" xlink:to="loc_us-gaap_Revenues_848CDAEBFDCC47777B25CD17BC780E97" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_E62698357E8CE93917C1CD17BC801F04" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfChangeInAccountingEstimateTable" xlink:label="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_94AB73FBE5918DD7511BCD17BC80F143" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_E62698357E8CE93917C1CD17BC801F04" xlink:to="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_94AB73FBE5918DD7511BCD17BC80F143" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_0999D0653FF50A7C6433CD17BC81E3B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_94AB73FBE5918DD7511BCD17BC80F143" xlink:to="loc_srt_StatementGeographicalAxis_0999D0653FF50A7C6433CD17BC81E3B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_E9A02AA8D539803EE31FCD17BC813472" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_0999D0653FF50A7C6433CD17BC81E3B4" xlink:to="loc_srt_SegmentGeographicalDomain_E9A02AA8D539803EE31FCD17BC813472" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_7A596EF7C64FF20E36B0CD17BC8186E2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_E9A02AA8D539803EE31FCD17BC813472" xlink:to="loc_country_US_7A596EF7C64FF20E36B0CD17BC8186E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_7196F139B192EC982E40CD17BC824EC6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_94AB73FBE5918DD7511BCD17BC80F143" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_7196F139B192EC982E40CD17BC824EC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_55E46D8CADAFDFA8373ECD17BC825759" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_7196F139B192EC982E40CD17BC824EC6" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_55E46D8CADAFDFA8373ECD17BC825759" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesReturnsAndAllowancesMember" xlink:label="loc_us-gaap_SalesReturnsAndAllowancesMember_029EFB52334ADB52CC7CCD17BC826BCF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_55E46D8CADAFDFA8373ECD17BC825759" xlink:to="loc_us-gaap_SalesReturnsAndAllowancesMember_029EFB52334ADB52CC7CCD17BC826BCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateLineItems" xlink:label="loc_us-gaap_ChangeInAccountingEstimateLineItems_B98F688DC1E10EEA1143CD17BC82692E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_94AB73FBE5918DD7511BCD17BC80F143" xlink:to="loc_us-gaap_ChangeInAccountingEstimateLineItems_B98F688DC1E10EEA1143CD17BC82692E" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent" xlink:label="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_FDD11663498D9B2CC3BCCD17BC82B653" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_B98F688DC1E10EEA1143CD17BC82692E" xlink:to="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_FDD11663498D9B2CC3BCCD17BC82B653" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueSummaryOfRevenueRecognizedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_42DBDF725FE7A954B282CD17BC857417" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_B21E5DE72196227909E2CD17BC857716" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_42DBDF725FE7A954B282CD17BC857417" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_B21E5DE72196227909E2CD17BC857716" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_1F5244FEF1B237FAAF2DCD17BC863C01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_B21E5DE72196227909E2CD17BC857716" xlink:to="loc_srt_ProductOrServiceAxis_1F5244FEF1B237FAAF2DCD17BC863C01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_058E1E954291C0DF4A81CD17BC866085" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_1F5244FEF1B237FAAF2DCD17BC863C01" xlink:to="loc_srt_ProductsAndServicesDomain_058E1E954291C0DF4A81CD17BC866085" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_9D96993EBF93E77D5C67CD17BC860BA9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_058E1E954291C0DF4A81CD17BC866085" xlink:to="loc_us-gaap_ProductMember_9D96993EBF93E77D5C67CD17BC860BA9" xlink:type="arc" />
    <link:loc xlink:href="lly-20200331.xsd#lly_CollaborationandOtherRevenueMember" xlink:label="loc_lly_CollaborationandOtherRevenueMember_6413796C7DCE919DEBDCCD17BC87C55C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_058E1E954291C0DF4A81CD17BC866085" xlink:to="loc_lly_CollaborationandOtherRevenueMember_6413796C7DCE919DEBDCCD17BC87C55C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyMember" xlink:label="loc_us-gaap_RoyaltyMember_24DEDC0B320F8849F252CD17BC87E4CD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_058E1E954291C0DF4A81CD17BC866085" xlink:to="loc_us-gaap_RoyaltyMember_24DEDC0B320F8849F252CD17BC87E4CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_05A0836B2CB3FECCA180CD17BC870214" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_B21E5DE72196227909E2CD17BC857716" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_05A0836B2CB3FECCA180CD17BC870214" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_B05D50B4C93D5B30B843CD17BC8721BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_05A0836B2CB3FECCA180CD17BC870214" xlink:to="loc_us-gaap_Revenues_B05D50B4C93D5B30B843CD17BC8721BD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.lilly.com/role/RevenueTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_FFCFE20240B75924651ECD17BC893A57" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_AB738F4EB860F3B3D62BCD17BC8A8A95" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_FFCFE20240B75924651ECD17BC893A57" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_AB738F4EB860F3B3D62BCD17BC8A8A95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_83281C9D5A082D86B504CD17BC8AF622" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_FFCFE20240B75924651ECD17BC893A57" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_83281C9D5A082D86B504CD17BC8AF622" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
