<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:583e66c6-00a3-4bc4-9f0c-7ddfb7b7e0b6,g:53c6f50d-ed03-4dd9-a654-7f11db7bca85-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.lilly.com/role/CoverPage" xlink:type="simple" xlink:href="lly-20240630.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_94971146-fa2e-47be-9603-1cf6e29e3ce4" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentInformationTable_94971146-fa2e-47be-9603-1cf6e29e3ce4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_00f7198f-3dce-4a43-97b2-c85468239647" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_94971146-fa2e-47be-9603-1cf6e29e3ce4" xlink:to="loc_us-gaap_StatementClassOfStockAxis_00f7198f-3dce-4a43-97b2-c85468239647" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_00f7198f-3dce-4a43-97b2-c85468239647_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_00f7198f-3dce-4a43-97b2-c85468239647" xlink:to="loc_us-gaap_ClassOfStockDomain_00f7198f-3dce-4a43-97b2-c85468239647_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_00f7198f-3dce-4a43-97b2-c85468239647" xlink:to="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_b4825c8a-2da6-4d4b-809f-6795e4101dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_us-gaap_CommonClassAMember_b4825c8a-2da6-4d4b-809f-6795e4101dbf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A718NotesDueJune12025Member_6d5b7c94-eccd-4990-a40f-5401a31274f7" xlink:href="lly-20240630.xsd#lly_A718NotesDueJune12025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A718NotesDueJune12025Member_6d5b7c94-eccd-4990-a40f-5401a31274f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1.625NotesDueJune22026Member_a95812e6-2ed4-4e28-acd4-a263f85311b7" xlink:href="lly-20240630.xsd#lly_A1.625NotesDueJune22026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A1.625NotesDueJune22026Member_a95812e6-2ed4-4e28-acd4-a263f85311b7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A2.125NotesDueJune32030Member_05b0ce78-fa4d-46bb-a054-805c71b1df10" xlink:href="lly-20240630.xsd#lly_A2.125NotesDueJune32030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A2.125NotesDueJune32030Member_05b0ce78-fa4d-46bb-a054-805c71b1df10" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A625NotesDue2031Member_8c7ecd65-75a4-4286-a765-9597c95eb4c0" xlink:href="lly-20240630.xsd#lly_A625NotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A625NotesDue2031Member_8c7ecd65-75a4-4286-a765-9597c95eb4c0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A500NotesDue2033Member_da6225a2-b9e7-489c-9f3a-710e51c5aadb" xlink:href="lly-20240630.xsd#lly_A500NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A500NotesDue2033Member_da6225a2-b9e7-489c-9f3a-710e51c5aadb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A6.77NotesDueJanuary12036Member_69b9f1ea-b41f-47a6-873e-aa9f559af9f7" xlink:href="lly-20240630.xsd#lly_A6.77NotesDueJanuary12036Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A6.77NotesDueJanuary12036Member_69b9f1ea-b41f-47a6-873e-aa9f559af9f7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1625NotesDue2043Member_4c8d4d56-2c73-4695-b97f-d5a094f7b8f4" xlink:href="lly-20240630.xsd#lly_A1625NotesDue2043Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A1625NotesDue2043Member_4c8d4d56-2c73-4695-b97f-d5a094f7b8f4" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1700NotesDue2049Member_c759515f-c18b-4d57-b12e-0ae4eca3f6fc" xlink:href="lly-20240630.xsd#lly_A1700NotesDue2049Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A1700NotesDue2049Member_c759515f-c18b-4d57-b12e-0ae4eca3f6fc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1125NotesDue2051Member_c7fbed3a-5c52-4456-827d-c6cb31d82e44" xlink:href="lly-20240630.xsd#lly_A1125NotesDue2051Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A1125NotesDue2051Member_c7fbed3a-5c52-4456-827d-c6cb31d82e44" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A1375NotesDue2061Member_e1612725-735d-4404-b8da-22056890db03" xlink:href="lly-20240630.xsd#lly_A1375NotesDue2061Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_31970ad6-186a-4089-9115-96acdcf3d15d" xlink:to="loc_lly_A1375NotesDue2061Member_e1612725-735d-4404-b8da-22056890db03" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_ad399c1f-6b09-40c4-afa4-34203096b83c" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentType_ad399c1f-6b09-40c4-afa4-34203096b83c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_46523de2-6f88-44ff-a82c-a11dc1f2af8b" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentPeriodEndDate_46523de2-6f88-44ff-a82c-a11dc1f2af8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_89d58551-b518-4157-bc5f-7e4f6eba3eb5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityFileNumber_89d58551-b518-4157-bc5f-7e4f6eba3eb5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_cc23f472-bfb9-4e7a-b291-cad49569cc8e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityRegistrantName_cc23f472-bfb9-4e7a-b291-cad49569cc8e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_4fbf4859-e77f-461b-95c8-fbdfe5d85040" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityIncorporationStateCountryCode_4fbf4859-e77f-461b-95c8-fbdfe5d85040" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_3f25301b-7ff7-4a7d-bcd7-bf91b41ddc4a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityTaxIdentificationNumber_3f25301b-7ff7-4a7d-bcd7-bf91b41ddc4a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_18691f20-0ac6-4bdc-bd5a-85244a4584da" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityAddressAddressLine1_18691f20-0ac6-4bdc-bd5a-85244a4584da" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_ae4f2da9-777c-4c80-ac0b-7abf7077a5a1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityAddressCityOrTown_ae4f2da9-777c-4c80-ac0b-7abf7077a5a1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_a5a59af3-a410-46bc-a610-8f133decb878" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityAddressStateOrProvince_a5a59af3-a410-46bc-a610-8f133decb878" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_f3013827-06e0-4707-a23e-ba54dca37549" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityAddressPostalZipCode_f3013827-06e0-4707-a23e-ba54dca37549" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_c8732fef-2170-4f0b-8758-8570eb5c68c4" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_CityAreaCode_c8732fef-2170-4f0b-8758-8570eb5c68c4" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_93b01a3d-4644-4610-ae47-7416e7f90bc1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_LocalPhoneNumber_93b01a3d-4644-4610-ae47-7416e7f90bc1" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_88bbf14a-60d7-4d7c-b43e-82b4c33d2e29" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_Security12bTitle_88bbf14a-60d7-4d7c-b43e-82b4c33d2e29" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6acfcd27-e77e-4492-8405-e4e447f98809" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_TradingSymbol_6acfcd27-e77e-4492-8405-e4e447f98809" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_5e48c319-5a51-4011-9644-f8548118c04f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_SecurityExchangeName_5e48c319-5a51-4011-9644-f8548118c04f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_84b493e2-50db-4a1f-8ea9-617854bcdafa" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityCurrentReportingStatus_84b493e2-50db-4a1f-8ea9-617854bcdafa" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_91eb13a5-f65f-4e94-8c57-ab67be8ba1c0" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityInteractiveDataCurrent_91eb13a5-f65f-4e94-8c57-ab67be8ba1c0" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_c8a91087-aad7-4525-9c88-2674a205bbe1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityFilerCategory_c8a91087-aad7-4525-9c88-2674a205bbe1" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_96be7e6b-9890-4e18-843e-ad5dd8b54583" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntitySmallBusiness_96be7e6b-9890-4e18-843e-ad5dd8b54583" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_08f532f8-0ff5-4f8f-9703-ccd644fbb14d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityEmergingGrowthCompany_08f532f8-0ff5-4f8f-9703-ccd644fbb14d" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_220878bc-d4e9-4f93-8690-e2cf8ff4fa49" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityShellCompany_220878bc-d4e9-4f93-8690-e2cf8ff4fa49" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_bb3ec2cd-249a-40ab-b63a-a420ab526e15" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_bb3ec2cd-249a-40ab-b63a-a420ab526e15" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_1192a681-9233-4da1-bbfc-613f23b61b03" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_AmendmentFlag_1192a681-9233-4da1-bbfc-613f23b61b03" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_9548a931-f883-4feb-b52d-df943a040e7d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentFiscalYearFocus_9548a931-f883-4feb-b52d-df943a040e7d" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_48ebe481-f78a-4487-82ec-a97859bacd55" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentFiscalPeriodFocus_48ebe481-f78a-4487-82ec-a97859bacd55" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_e54c757c-f10d-45f1-a230-3a9dc5b872da" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_EntityCentralIndexKey_e54c757c-f10d-45f1-a230-3a9dc5b872da" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_86ccb350-8e01-4010-a926-a3265d6555a6" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_CurrentFiscalYearEndDate_86ccb350-8e01-4010-a926-a3265d6555a6" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_1247c045-6b41-44ff-9013-d5847d163075" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentQuarterlyReport_1247c045-6b41-44ff-9013-d5847d163075" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_9c8727c5-ba80-40ca-8cd4-aa3a4ea80d59" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_dfec69f4-76e0-48f5-9601-b6ecd7a31aa1" xlink:to="loc_dei_DocumentTransitionReport_9c8727c5-ba80-40ca-8cd4-aa3a4ea80d59" xlink:type="arc" order="28"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsofShareholdersEquityUnaudited" xlink:type="simple" xlink:href="lly-20240630.xsd#ConsolidatedCondensedStatementsofShareholdersEquityUnaudited"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsofShareholdersEquityUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_ef9f24a8-e845-47ca-b44c-66516010aa50" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_b633ed1c-7f4e-4379-8597-1a4daeed5d90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_ef9f24a8-e845-47ca-b44c-66516010aa50" xlink:to="loc_us-gaap_StatementTable_b633ed1c-7f4e-4379-8597-1a4daeed5d90" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f440bc6b-ab08-44dd-a353-7fd0323613fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_b633ed1c-7f4e-4379-8597-1a4daeed5d90" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f440bc6b-ab08-44dd-a353-7fd0323613fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f440bc6b-ab08-44dd-a353-7fd0323613fd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f440bc6b-ab08-44dd-a353-7fd0323613fd" xlink:to="loc_us-gaap_EquityComponentDomain_f440bc6b-ab08-44dd-a353-7fd0323613fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f440bc6b-ab08-44dd-a353-7fd0323613fd" xlink:to="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_d1ab2048-fa30-4cca-92be-2eaecf75d408" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_CommonStockMember_d1ab2048-fa30-4cca-92be-2eaecf75d408" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_d91fd500-9aab-480b-9a04-c8a70de89e28" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_d91fd500-9aab-480b-9a04-c8a70de89e28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_00d6b4ea-8c92-4a10-9849-ee7572950b36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_RetainedEarningsMember_00d6b4ea-8c92-4a10-9849-ee7572950b36" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_d0a365ec-a508-4d8b-8e86-17e915edab79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TrustForBenefitOfEmployeesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_d0a365ec-a508-4d8b-8e86-17e915edab79" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_927c5628-1c3a-471f-b7c2-d99e80b17185" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_927c5628-1c3a-471f-b7c2-d99e80b17185" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_9b50d45f-f4fa-4057-9591-6904a157631f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_TreasuryStockCommonMember_9b50d45f-f4fa-4057-9591-6904a157631f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_ed880564-8d8a-4c9f-9f48-4252f93213ef" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c4ea1c92-ee21-4c8e-bd8b-67db746a7bab" xlink:to="loc_us-gaap_NoncontrollingInterestMember_ed880564-8d8a-4c9f-9f48-4252f93213ef" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ef9f24a8-e845-47ca-b44c-66516010aa50" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_16edd9a0-90f9-4ac5-a4c0-0d9f450062fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_CommonStockSharesIssued_16edd9a0-90f9-4ac5-a4c0-0d9f450062fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_27d5612a-5136-4b34-8cc6-d1e7bb9c89d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_TreasuryStockCommonShares_27d5612a-5136-4b34-8cc6-d1e7bb9c89d5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8a672c7e-77e2-40a4-95b7-2a0465987aa9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8a672c7e-77e2-40a4-95b7-2a0465987aa9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_7b9a152d-961c-4063-b3d3-db4a048a0dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_ProfitLoss_7b9a152d-961c-4063-b3d3-db4a048a0dfb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_e487dbd1-ccd5-49b5-a03e-8318c5527917" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_e487dbd1-ccd5-49b5-a03e-8318c5527917" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Dividends_083cac52-2585-4da4-a29d-9a964177a4cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Dividends"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_Dividends_083cac52-2585-4da4-a29d-9a964177a4cb" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_76d78564-77d9-48f1-81ac-4ce5483ba218" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockSharesRetired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_76d78564-77d9-48f1-81ac-4ce5483ba218" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_84901cf0-e530-4673-9052-35cb98338c3e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_84901cf0-e530-4673-9052-35cb98338c3e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_e61d798c-f52a-46c4-8af5-f4e5d8a305c6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_e61d798c-f52a-46c4-8af5-f4e5d8a305c6" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_74e94498-5aa7-4ffb-a54d-8aed1bfd0347" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_74e94498-5aa7-4ffb-a54d-8aed1bfd0347" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_97cc52b0-04da-4f41-9e26-dea99653bfff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_97cc52b0-04da-4f41-9e26-dea99653bfff" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_70bcbb43-5a9b-4d20-8870-78bf718254f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_70bcbb43-5a9b-4d20-8870-78bf718254f5" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_586ad127-69f1-48fb-8023-3bac835c30bb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_586ad127-69f1-48fb-8023-3bac835c30bb" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_238395de-49c5-4bad-adf8-abe121129e60" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a2dacf47-347a-4587-b76a-17ae6c7de488" xlink:to="loc_us-gaap_StockholdersEquityOther_238395de-49c5-4bad-adf8-abe121129e60" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_5280dd15-1619-4ced-9ae9-77f71a308470" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_7b891cab-c88b-41f9-b72b-41591a355cea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_83b2535d-5eb4-4d4d-b418-8669c3199f34" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueScheduleofRevenueRecognizedDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#RevenueScheduleofRevenueRecognizedDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueScheduleofRevenueRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_f9485e73-04af-4a76-942c-1e4bbe2cb731" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_b69f3912-1292-4b05-9c6d-afc0b554663d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_f9485e73-04af-4a76-942c-1e4bbe2cb731" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_b69f3912-1292-4b05-9c6d-afc0b554663d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_8162354a-8d0e-45cc-ac45-06be3216d929" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b69f3912-1292-4b05-9c6d-afc0b554663d" xlink:to="loc_srt_ProductOrServiceAxis_8162354a-8d0e-45cc-ac45-06be3216d929" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_8162354a-8d0e-45cc-ac45-06be3216d929_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_8162354a-8d0e-45cc-ac45-06be3216d929" xlink:to="loc_srt_ProductsAndServicesDomain_8162354a-8d0e-45cc-ac45-06be3216d929_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6287c44b-1205-417a-8a71-1a262e4c67da" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_8162354a-8d0e-45cc-ac45-06be3216d929" xlink:to="loc_srt_ProductsAndServicesDomain_6287c44b-1205-417a-8a71-1a262e4c67da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_ceec3767-0f30-4cc1-abf4-1b3046b974bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6287c44b-1205-417a-8a71-1a262e4c67da" xlink:to="loc_us-gaap_ProductMember_ceec3767-0f30-4cc1-abf4-1b3046b974bc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborationandOtherRevenueMember_2e7de2ca-ba8c-4e14-b533-97a6c8b780ca" xlink:href="lly-20240630.xsd#lly_CollaborationandOtherRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6287c44b-1205-417a-8a71-1a262e4c67da" xlink:to="loc_lly_CollaborationandOtherRevenueMember_2e7de2ca-ba8c-4e14-b533-97a6c8b780ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_7fd5b7d3-87fc-498b-958c-69d192b3ffed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_f9485e73-04af-4a76-942c-1e4bbe2cb731" xlink:to="loc_us-gaap_Revenues_7fd5b7d3-87fc-498b-958c-69d192b3ffed" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueAdjustmentstoRevenueDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#RevenueAdjustmentstoRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueAdjustmentstoRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateLineItems_38ed2c41-234e-40eb-99a4-82810e1fd14f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInAccountingEstimateLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_b7745aba-d9b3-453c-bcb9-1b1afd4a3d57" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfChangeInAccountingEstimateTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_38ed2c41-234e-40eb-99a4-82810e1fd14f" xlink:to="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_b7745aba-d9b3-453c-bcb9-1b1afd4a3d57" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_cf1b60df-1d1f-4216-8e0f-557e01a0dafd" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_b7745aba-d9b3-453c-bcb9-1b1afd4a3d57" xlink:to="loc_srt_StatementGeographicalAxis_cf1b60df-1d1f-4216-8e0f-557e01a0dafd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_cf1b60df-1d1f-4216-8e0f-557e01a0dafd_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_cf1b60df-1d1f-4216-8e0f-557e01a0dafd" xlink:to="loc_srt_SegmentGeographicalDomain_cf1b60df-1d1f-4216-8e0f-557e01a0dafd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_483080bf-6bc2-49e9-9914-873dbb0dac2a" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_cf1b60df-1d1f-4216-8e0f-557e01a0dafd" xlink:to="loc_srt_SegmentGeographicalDomain_483080bf-6bc2-49e9-9914-873dbb0dac2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_df8d9a40-b913-4456-b98b-183081ecf2a8" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_483080bf-6bc2-49e9-9914-873dbb0dac2a" xlink:to="loc_country_US_df8d9a40-b913-4456-b98b-183081ecf2a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_04a58e45-68fb-42a0-aec7-27ef29e1ad9f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_b7745aba-d9b3-453c-bcb9-1b1afd4a3d57" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_04a58e45-68fb-42a0-aec7-27ef29e1ad9f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_04a58e45-68fb-42a0-aec7-27ef29e1ad9f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_04a58e45-68fb-42a0-aec7-27ef29e1ad9f" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_04a58e45-68fb-42a0-aec7-27ef29e1ad9f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_554fe5a8-74ba-47d9-8e77-20f5a53647d2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_04a58e45-68fb-42a0-aec7-27ef29e1ad9f" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_554fe5a8-74ba-47d9-8e77-20f5a53647d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesReturnsAndAllowancesMember_138f1ac6-0c83-4556-9ceb-649b94a05108" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SalesReturnsAndAllowancesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_554fe5a8-74ba-47d9-8e77-20f5a53647d2" xlink:to="loc_us-gaap_SalesReturnsAndAllowancesMember_138f1ac6-0c83-4556-9ceb-649b94a05108" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_af34350a-c419-457c-a7d3-6e10deee2575" xlink:href="lly-20240630.xsd#lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_38ed2c41-234e-40eb-99a4-82810e1fd14f" xlink:to="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_af34350a-c419-457c-a7d3-6e10deee2575" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyProductDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#RevenueDisaggregationofRevenuebyProductDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyProductDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_ce279ea8-480c-4907-ab99-ea6b94d8a7cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_c535712d-34cb-44dc-a218-1366128bd6af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_ce279ea8-480c-4907-ab99-ea6b94d8a7cb" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_c535712d-34cb-44dc-a218-1366128bd6af" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_91a5799e-a9d2-4fea-b5b4-1083abd63499" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_c535712d-34cb-44dc-a218-1366128bd6af" xlink:to="loc_srt_ProductOrServiceAxis_91a5799e-a9d2-4fea-b5b4-1083abd63499" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_91a5799e-a9d2-4fea-b5b4-1083abd63499_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_91a5799e-a9d2-4fea-b5b4-1083abd63499" xlink:to="loc_srt_ProductsAndServicesDomain_91a5799e-a9d2-4fea-b5b4-1083abd63499_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_91a5799e-a9d2-4fea-b5b4-1083abd63499" xlink:to="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:href="lly-20240630.xsd#lly_CardiometabolicHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:to="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MounjaroMember_90517a60-8c75-4291-ab4c-735f9cbeae9d" xlink:href="lly-20240630.xsd#lly_MounjaroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_MounjaroMember_90517a60-8c75-4291-ab4c-735f9cbeae9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TrulicityMember_d7c1b52f-e5d9-4947-a8e4-7b8371474321" xlink:href="lly-20240630.xsd#lly_TrulicityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_TrulicityMember_d7c1b52f-e5d9-4947-a8e4-7b8371474321" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ZepboundMember_579ac5c8-dca2-4b5b-846f-b915b685752a" xlink:href="lly-20240630.xsd#lly_ZepboundMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_ZepboundMember_579ac5c8-dca2-4b5b-846f-b915b685752a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_JardianceMember_1c6a3a36-641a-4f4e-811b-f0a5c3459051" xlink:href="lly-20240630.xsd#lly_JardianceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_JardianceMember_1c6a3a36-641a-4f4e-811b-f0a5c3459051" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HumalogMember_a46bcf07-63f6-4a7e-8b4e-342d9676a645" xlink:href="lly-20240630.xsd#lly_HumalogMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_HumalogMember_a46bcf07-63f6-4a7e-8b4e-342d9676a645" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HumulinMember_4f293f08-95a2-4211-b308-d36dba1269f2" xlink:href="lly-20240630.xsd#lly_HumulinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_HumulinMember_4f293f08-95a2-4211-b308-d36dba1269f2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BasaglarMember_66875c18-c0d3-4525-ad75-dfd767be56a4" xlink:href="lly-20240630.xsd#lly_BasaglarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_BasaglarMember_66875c18-c0d3-4525-ad75-dfd767be56a4" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BaqsimiMember_09d2751f-eec9-4633-b952-36ca905a1f42" xlink:href="lly-20240630.xsd#lly_BaqsimiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_BaqsimiMember_09d2751f-eec9-4633-b952-36ca905a1f42" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherCardiometabolicHealthMember_4ecc55cb-0b13-4782-b9b6-3db39e9aed08" xlink:href="lly-20240630.xsd#lly_OtherCardiometabolicHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CardiometabolicHealthMember_1aee15e6-3593-4609-808f-becc568360ad" xlink:to="loc_lly_OtherCardiometabolicHealthMember_4ecc55cb-0b13-4782-b9b6-3db39e9aed08" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:href="lly-20240630.xsd#lly_OncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:to="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_VerzenioMember_7d75eda8-f269-40c4-959f-eed3ef6d7320" xlink:href="lly-20240630.xsd#lly_VerzenioMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:to="loc_lly_VerzenioMember_7d75eda8-f269-40c4-959f-eed3ef6d7320" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CyramzaMember_18221055-fe43-4049-8f46-d5c693082ad0" xlink:href="lly-20240630.xsd#lly_CyramzaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:to="loc_lly_CyramzaMember_18221055-fe43-4049-8f46-d5c693082ad0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ErbituxMember_732c24bf-a5f0-4d2d-ad24-1c657e2cbf09" xlink:href="lly-20240630.xsd#lly_ErbituxMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:to="loc_lly_ErbituxMember_732c24bf-a5f0-4d2d-ad24-1c657e2cbf09" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TyvytMember_e64e909e-039b-4d98-a8df-8cb41a9e4c48" xlink:href="lly-20240630.xsd#lly_TyvytMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:to="loc_lly_TyvytMember_e64e909e-039b-4d98-a8df-8cb41a9e4c48" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherOncologyMember_9576035c-4565-4b3a-855e-76c768b3adb9" xlink:href="lly-20240630.xsd#lly_OtherOncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_7642f768-4f53-4455-969e-f994a6cb1388" xlink:to="loc_lly_OtherOncologyMember_9576035c-4565-4b3a-855e-76c768b3adb9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ImmunologyMember_9b386b90-41bc-4eb0-a110-3374deda4d4d" xlink:href="lly-20240630.xsd#lly_ImmunologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:to="loc_lly_ImmunologyMember_9b386b90-41bc-4eb0-a110-3374deda4d4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TaltzMember_b6c97822-a778-4204-9093-b8af3cca8dd0" xlink:href="lly-20240630.xsd#lly_TaltzMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_9b386b90-41bc-4eb0-a110-3374deda4d4d" xlink:to="loc_lly_TaltzMember_b6c97822-a778-4204-9093-b8af3cca8dd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_67a9a9df-f0b7-4764-9684-cafa6eda3a54" xlink:href="lly-20240630.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_9b386b90-41bc-4eb0-a110-3374deda4d4d" xlink:to="loc_lly_OlumiantMember_67a9a9df-f0b7-4764-9684-cafa6eda3a54" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherImmunologyMember_b2d2488e-c0d6-412d-8ad1-4567f547f4fe" xlink:href="lly-20240630.xsd#lly_OtherImmunologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_9b386b90-41bc-4eb0-a110-3374deda4d4d" xlink:to="loc_lly_OtherImmunologyMember_b2d2488e-c0d6-412d-8ad1-4567f547f4fe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_NeuroscienceMember_a630073c-5a21-48dd-b9f2-d8163eaab4cd" xlink:href="lly-20240630.xsd#lly_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:to="loc_lly_NeuroscienceMember_a630073c-5a21-48dd-b9f2-d8163eaab4cd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmgalityMember_9504e3ac-8b05-48fc-85f0-47eaf7601080" xlink:href="lly-20240630.xsd#lly_EmgalityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_a630073c-5a21-48dd-b9f2-d8163eaab4cd" xlink:to="loc_lly_EmgalityMember_9504e3ac-8b05-48fc-85f0-47eaf7601080" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherNeuroscienceMember_8d4409a0-bb79-4e07-b88f-6bf75dd8c012" xlink:href="lly-20240630.xsd#lly_OtherNeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_a630073c-5a21-48dd-b9f2-d8163eaab4cd" xlink:to="loc_lly_OtherNeuroscienceMember_8d4409a0-bb79-4e07-b88f-6bf75dd8c012" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherProductTotalMember_e8ba96f1-6310-4e9c-8536-89bcd264016a" xlink:href="lly-20240630.xsd#lly_OtherProductTotalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_51f323e5-1c23-48b6-9f95-b271c628788d" xlink:to="loc_lly_OtherProductTotalMember_e8ba96f1-6310-4e9c-8536-89bcd264016a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CialisMember_a5136581-acb3-44a8-8400-59229ee2fa84" xlink:href="lly-20240630.xsd#lly_CialisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_e8ba96f1-6310-4e9c-8536-89bcd264016a" xlink:to="loc_lly_CialisMember_a5136581-acb3-44a8-8400-59229ee2fa84" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ForteoMember_d340ae70-3405-47f1-89f9-64266392512b" xlink:href="lly-20240630.xsd#lly_ForteoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_e8ba96f1-6310-4e9c-8536-89bcd264016a" xlink:to="loc_lly_ForteoMember_d340ae70-3405-47f1-89f9-64266392512b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherProductMember_82913a15-276b-4813-a074-435b7b7dda66" xlink:href="lly-20240630.xsd#lly_OtherProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_e8ba96f1-6310-4e9c-8536-89bcd264016a" xlink:to="loc_lly_OtherProductMember_82913a15-276b-4813-a074-435b7b7dda66" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_1d69aeaf-1020-4eec-9c6f-747b50100ae9" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_c535712d-34cb-44dc-a218-1366128bd6af" xlink:to="loc_srt_StatementGeographicalAxis_1d69aeaf-1020-4eec-9c6f-747b50100ae9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_1d69aeaf-1020-4eec-9c6f-747b50100ae9_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_1d69aeaf-1020-4eec-9c6f-747b50100ae9" xlink:to="loc_srt_SegmentGeographicalDomain_1d69aeaf-1020-4eec-9c6f-747b50100ae9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_662384aa-1410-42a2-a19e-52180f048f15" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_1d69aeaf-1020-4eec-9c6f-747b50100ae9" xlink:to="loc_srt_SegmentGeographicalDomain_662384aa-1410-42a2-a19e-52180f048f15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_a8b4af9c-d4ab-45ef-92d2-bf752cf505c7" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_662384aa-1410-42a2-a19e-52180f048f15" xlink:to="loc_country_US_a8b4af9c-d4ab-45ef-92d2-bf752cf505c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_8eaa61fd-7121-4c73-9e80-e84358d3293a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_662384aa-1410-42a2-a19e-52180f048f15" xlink:to="loc_us-gaap_NonUsMember_8eaa61fd-7121-4c73-9e80-e84358d3293a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_81ad7596-00ee-4bb6-a812-da88af91a76f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_ce279ea8-480c-4907-ab99-ea6b94d8a7cb" xlink:to="loc_us-gaap_Revenues_81ad7596-00ee-4bb6-a812-da88af91a76f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyGeographicalAreaDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#RevenueDisaggregationofRevenuebyGeographicalAreaDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationofRevenuebyGeographicalAreaDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_7fc9c1b7-50c9-43fc-b2e1-c92872661cfa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_a7e3942b-81d1-4f06-b116-3116aca5e07f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7fc9c1b7-50c9-43fc-b2e1-c92872661cfa" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_a7e3942b-81d1-4f06-b116-3116aca5e07f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_065e4cf2-d704-4b2a-b959-701e6dd2217f" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a7e3942b-81d1-4f06-b116-3116aca5e07f" xlink:to="loc_srt_StatementGeographicalAxis_065e4cf2-d704-4b2a-b959-701e6dd2217f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_065e4cf2-d704-4b2a-b959-701e6dd2217f_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_065e4cf2-d704-4b2a-b959-701e6dd2217f" xlink:to="loc_srt_SegmentGeographicalDomain_065e4cf2-d704-4b2a-b959-701e6dd2217f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_065e4cf2-d704-4b2a-b959-701e6dd2217f" xlink:to="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_aa2330c4-a225-4437-83b3-a01502302e2a" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:to="loc_country_US_aa2330c4-a225-4437-83b3-a01502302e2a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_e1323f65-7515-4dab-8e5f-b7d64badd6de" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:to="loc_srt_EuropeMember_e1323f65-7515-4dab-8e5f-b7d64badd6de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_JP_350ab497-cf42-4f72-9144-1ce08c0adfd7" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_JP"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:to="loc_country_JP_350ab497-cf42-4f72-9144-1ce08c0adfd7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CN_8a1caa2b-3fdc-4aee-be46-5d0ceecf3437" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_CN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:to="loc_country_CN_8a1caa2b-3fdc-4aee-be46-5d0ceecf3437" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherForeignCountriesMember_4c19c61c-41ce-4929-8187-2305709476ee" xlink:href="lly-20240630.xsd#lly_OtherForeignCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2ed1a46c-9f51-4d6d-8b5a-c097f180160e" xlink:to="loc_lly_OtherForeignCountriesMember_4c19c61c-41ce-4929-8187-2305709476ee" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_f6ac7e41-9d13-44d1-a9eb-9bfaf1c55ac0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7fc9c1b7-50c9-43fc-b2e1-c92872661cfa" xlink:to="loc_us-gaap_Revenues_f6ac7e41-9d13-44d1-a9eb-9bfaf1c55ac0" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3f7e6c6e-7786-42ff-9acd-ce15cc87f29c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3f7e6c6e-7786-42ff-9acd-ce15cc87f29c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_114ab3f2-b54c-49b7-9e56-21c275a2bcf2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3f7e6c6e-7786-42ff-9acd-ce15cc87f29c" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_114ab3f2-b54c-49b7-9e56-21c275a2bcf2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_114ab3f2-b54c-49b7-9e56-21c275a2bcf2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_114ab3f2-b54c-49b7-9e56-21c275a2bcf2" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_114ab3f2-b54c-49b7-9e56-21c275a2bcf2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_31788711-d649-41ee-8e12-fff730a13228" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_114ab3f2-b54c-49b7-9e56-21c275a2bcf2" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_31788711-d649-41ee-8e12-fff730a13228" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_PointBiopharmaGlobalIncMember_5b11db75-b3be-4b4c-b806-9467f69c8b1f" xlink:href="lly-20240630.xsd#lly_PointBiopharmaGlobalIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_31788711-d649-41ee-8e12-fff730a13228" xlink:to="loc_lly_PointBiopharmaGlobalIncMember_5b11db75-b3be-4b4c-b806-9467f69c8b1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember_65fc3a9d-679d-460b-98c7-32f0bdfa4e05" xlink:href="lly-20240630.xsd#lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_31788711-d649-41ee-8e12-fff730a13228" xlink:to="loc_lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember_65fc3a9d-679d-460b-98c7-32f0bdfa4e05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MorphicHoldingIncMember_f3d7b7bd-0a4a-4cf0-85c9-43100b4bb27d" xlink:href="lly-20240630.xsd#lly_MorphicHoldingIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_31788711-d649-41ee-8e12-fff730a13228" xlink:to="loc_lly_MorphicHoldingIncMember_f3d7b7bd-0a4a-4cf0-85c9-43100b4bb27d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3f7e6c6e-7786-42ff-9acd-ce15cc87f29c" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_ea2e944b-f646-4df6-ba3e-6fc8ef4ac2da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7e5e8aa6-7e97-4e9c-82f4-1831d24dd297" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_ea2e944b-f646-4df6-ba3e-6fc8ef4ac2da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_79a893f1-3809-4f64-ba8f-7cd02c82c3f6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_ea2e944b-f646-4df6-ba3e-6fc8ef4ac2da" xlink:to="loc_us-gaap_SubsequentEventMember_79a893f1-3809-4f64-ba8f-7cd02c82c3f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_b3a76eb0-ab9b-4432-a2f4-c83a7fc73b66" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_b3a76eb0-ab9b-4432-a2f4-c83a7fc73b66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_775eebfa-0bf6-484a-9738-088e0b9d4112" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionSharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_BusinessAcquisitionSharePrice_775eebfa-0bf6-484a-9738-088e0b9d4112" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_975ee29a-ec36-4ddf-8d4f-6db119b0a622" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_975ee29a-ec36-4ddf-8d4f-6db119b0a622" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_288e4800-7625-4ff9-8b3d-45fc3899c657" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_288e4800-7625-4ff9-8b3d-45fc3899c657" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_f8ac714d-e003-4951-8b3f-9255b5e7d6e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4f825584-9b58-4507-ae76-1ca62aa851fa" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_f8ac714d-e003-4951-8b3f-9255b5e7d6e8" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ee0959e-4c43-4a21-b91f-2e8e78e5fd1f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ee0959e-4c43-4a21-b91f-2e8e78e5fd1f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_758373a8-ff07-4c31-9bf2-0771d4882642" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ee0959e-4c43-4a21-b91f-2e8e78e5fd1f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_758373a8-ff07-4c31-9bf2-0771d4882642" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_758373a8-ff07-4c31-9bf2-0771d4882642_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_758373a8-ff07-4c31-9bf2-0771d4882642" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_758373a8-ff07-4c31-9bf2-0771d4882642_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0856fe81-73a6-4696-91ec-a6480fe8719f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_758373a8-ff07-4c31-9bf2-0771d4882642" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0856fe81-73a6-4696-91ec-a6480fe8719f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember_b1d444cd-a02c-4ac2-9b11-5b3d0fc20e1a" xlink:href="lly-20240630.xsd#lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0856fe81-73a6-4696-91ec-a6480fe8719f" xlink:to="loc_lly_NexPharmParentHoldCoLLCAndIsoproHoldingsLLCMember_b1d444cd-a02c-4ac2-9b11-5b3d0fc20e1a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_PointBiopharmaGlobalIncMember_0ee28d9e-a61f-463b-9958-8ed35468d70b" xlink:href="lly-20240630.xsd#lly_PointBiopharmaGlobalIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0856fe81-73a6-4696-91ec-a6480fe8719f" xlink:to="loc_lly_PointBiopharmaGlobalIncMember_0ee28d9e-a61f-463b-9958-8ed35468d70b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_ef006081-b4e2-444c-a197-f3e8f6d5187b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_ef006081-b4e2-444c-a197-f3e8f6d5187b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_6f6ee28f-6a20-4adc-a425-4b6e3b77ebcd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_6f6ee28f-6a20-4adc-a425-4b6e3b77ebcd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_e8dd261d-1d75-48a1-915a-e71d1981eb7b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_Goodwill_e8dd261d-1d75-48a1-915a-e71d1981eb7b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_03709605-e9a9-45f6-9353-03971ba8aae6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_03709605-e9a9-45f6-9353-03971ba8aae6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_aef5c951-b99e-44bb-b7b0-0947947df1d0" xlink:href="lly-20240630.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsLiabilitiesNet_aef5c951-b99e-44bb-b7b0-0947947df1d0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_bf1bb2fc-07b1-428e-ac42-673e7ecf7561" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_bf1bb2fc-07b1-428e-ac42-673e7ecf7561" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BusinessCombinationCashAcquiredAbstract_022695ef-df26-48ca-9464-b6fc611e8566" xlink:href="lly-20240630.xsd#lly_BusinessCombinationCashAcquiredAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_lly_BusinessCombinationCashAcquiredAbstract_022695ef-df26-48ca-9464-b6fc611e8566" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAcquiredFromAcquisition_fcf552cb-8457-4516-9d23-5fccfd00d26a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAcquiredFromAcquisition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_BusinessCombinationCashAcquiredAbstract_022695ef-df26-48ca-9464-b6fc611e8566" xlink:to="loc_us-gaap_CashAcquiredFromAcquisition_fcf552cb-8457-4516-9d23-5fccfd00d26a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_6258d766-5bfe-4751-a59a-083b8ddcbb20" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_4135655b-beba-4b1a-9a22-036dc42bf95f" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_6258d766-5bfe-4751-a59a-083b8ddcbb20" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsandOtherArrangementsNetProductRevenueDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#CollaborationsandOtherArrangementsNetProductRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsandOtherArrangementsNetProductRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1a1fddb8-9ac4-4ab5-a46e-dce876f0ed35" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_50553530-a8b8-4635-8517-f019ed51aff6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1a1fddb8-9ac4-4ab5-a46e-dce876f0ed35" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_50553530-a8b8-4635-8517-f019ed51aff6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_46daee0d-a230-4c45-9803-67423318a498" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_50553530-a8b8-4635-8517-f019ed51aff6" xlink:to="loc_srt_ProductOrServiceAxis_46daee0d-a230-4c45-9803-67423318a498" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_46daee0d-a230-4c45-9803-67423318a498_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_46daee0d-a230-4c45-9803-67423318a498" xlink:to="loc_srt_ProductsAndServicesDomain_46daee0d-a230-4c45-9803-67423318a498_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_46daee0d-a230-4c45-9803-67423318a498" xlink:to="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_JardianceMember_2930e188-94dd-44de-b42d-c39b62c55ad2" xlink:href="lly-20240630.xsd#lly_JardianceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:to="loc_lly_JardianceMember_2930e188-94dd-44de-b42d-c39b62c55ad2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BasaglarMember_af587bfc-a7f8-40af-92c2-58f8dd056d4b" xlink:href="lly-20240630.xsd#lly_BasaglarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:to="loc_lly_BasaglarMember_af587bfc-a7f8-40af-92c2-58f8dd056d4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TrajentaBIMember_adaf1df2-d70e-49b2-80b8-970d35bf9819" xlink:href="lly-20240630.xsd#lly_TrajentaBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:to="loc_lly_TrajentaBIMember_adaf1df2-d70e-49b2-80b8-970d35bf9819" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_ad881caf-43cf-43ef-8d6b-0aa4e6373897" xlink:href="lly-20240630.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:to="loc_lly_OlumiantMember_ad881caf-43cf-43ef-8d6b-0aa4e6373897" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_TyvytMember_d1a7db42-e9e8-4921-a03b-7f23c2e46a59" xlink:href="lly-20240630.xsd#lly_TyvytMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4cd626b1-9454-48ec-a2b8-fe03c370b31a" xlink:to="loc_lly_TyvytMember_d1a7db42-e9e8-4921-a03b-7f23c2e46a59" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_4bd31bac-1815-4a14-8f77-34d071512e60" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1a1fddb8-9ac4-4ab5-a46e-dce876f0ed35" xlink:to="loc_us-gaap_Revenues_4bd31bac-1815-4a14-8f77-34d071512e60" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsandOtherArrangementsNarrativeDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#CollaborationsandOtherArrangementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsandOtherArrangementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_0463b403-e92d-4d94-b367-97be26bcd357" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:to="loc_us-gaap_TypeOfArrangementAxis_0463b403-e92d-4d94-b367-97be26bcd357" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0463b403-e92d-4d94-b367-97be26bcd357_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_0463b403-e92d-4d94-b367-97be26bcd357" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0463b403-e92d-4d94-b367-97be26bcd357_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_34e2a268-e06c-4f51-bc85-eb53ba722d56" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_0463b403-e92d-4d94-b367-97be26bcd357" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_34e2a268-e06c-4f51-bc85-eb53ba722d56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_334b9130-6d54-4021-a8fc-c3b32b7c1196" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RoyaltyAgreementTermsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_34e2a268-e06c-4f51-bc85-eb53ba722d56" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_334b9130-6d54-4021-a8fc-c3b32b7c1196" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_f36f0d28-5855-484d-8417-1c4fff76298a" xlink:href="lly-20240630.xsd#lly_MilestonePaymentsSalesBasedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_34e2a268-e06c-4f51-bc85-eb53ba722d56" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_f36f0d28-5855-484d-8417-1c4fff76298a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_b60b8ff1-472f-4f3d-8d73-4184c7f96856" xlink:href="lly-20240630.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_34e2a268-e06c-4f51-bc85-eb53ba722d56" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_b60b8ff1-472f-4f3d-8d73-4184c7f96856" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:to="loc_srt_ProductOrServiceAxis_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c" xlink:to="loc_srt_ProductsAndServicesDomain_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d811e0a0-1dbd-4801-b789-b4a3a6aebc91" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_c8bb95b9-8b59-4501-93e0-1478ce9e0d1c" xlink:to="loc_srt_ProductsAndServicesDomain_d811e0a0-1dbd-4801-b789-b4a3a6aebc91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OlumiantMember_3e63eb20-1e9c-4df7-9c76-0019a6b77f35" xlink:href="lly-20240630.xsd#lly_OlumiantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d811e0a0-1dbd-4801-b789-b4a3a6aebc91" xlink:to="loc_lly_OlumiantMember_3e63eb20-1e9c-4df7-9c76-0019a6b77f35" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EbglyssMember_30f34829-bdff-4999-9bd7-654e5bdf66bf" xlink:href="lly-20240630.xsd#lly_EbglyssMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d811e0a0-1dbd-4801-b789-b4a3a6aebc91" xlink:to="loc_lly_EbglyssMember_30f34829-bdff-4999-9bd7-654e5bdf66bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OrforglipronMember_3cc6d82d-48cd-4bbc-99eb-5fbf5a4bab5c" xlink:href="lly-20240630.xsd#lly_OrforglipronMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d811e0a0-1dbd-4801-b789-b4a3a6aebc91" xlink:to="loc_lly_OrforglipronMember_3cc6d82d-48cd-4bbc-99eb-5fbf5a4bab5c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_bdaf1637-386d-4685-a3a1-d5f0b75a1726" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:to="loc_dei_LegalEntityAxis_bdaf1637-386d-4685-a3a1-d5f0b75a1726" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_bdaf1637-386d-4685-a3a1-d5f0b75a1726_default" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_bdaf1637-386d-4685-a3a1-d5f0b75a1726" xlink:to="loc_dei_EntityDomain_bdaf1637-386d-4685-a3a1-d5f0b75a1726_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_96c02aac-09a4-44f7-87ba-20b2026d0a22" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_bdaf1637-386d-4685-a3a1-d5f0b75a1726" xlink:to="loc_dei_EntityDomain_96c02aac-09a4-44f7-87ba-20b2026d0a22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_RocheMember_e1954122-dabf-460a-87e3-c58056da233d" xlink:href="lly-20240630.xsd#lly_RocheMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_96c02aac-09a4-44f7-87ba-20b2026d0a22" xlink:to="loc_lly_RocheMember_e1954122-dabf-460a-87e3-c58056da233d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ChugaiMember_037b1177-e072-4217-abe7-1f4ae03f1099" xlink:href="lly-20240630.xsd#lly_ChugaiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_96c02aac-09a4-44f7-87ba-20b2026d0a22" xlink:to="loc_lly_ChugaiMember_037b1177-e072-4217-abe7-1f4ae03f1099" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_aa418e19-cc39-4d26-b70b-c127c3953d26" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_aa418e19-cc39-4d26-b70b-c127c3953d26" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_aa418e19-cc39-4d26-b70b-c127c3953d26_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_aa418e19-cc39-4d26-b70b-c127c3953d26" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_aa418e19-cc39-4d26-b70b-c127c3953d26_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_99109ec6-6d6d-40c0-b65b-67338b35bd50" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_aa418e19-cc39-4d26-b70b-c127c3953d26" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_99109ec6-6d6d-40c0-b65b-67338b35bd50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_4f5c6646-05a6-4468-92e5-c4a3b4b901ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_99109ec6-6d6d-40c0-b65b-67338b35bd50" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_4f5c6646-05a6-4468-92e5-c4a3b4b901ea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ac0301d6-df05-428e-88be-5c0f4f7b654b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_54e26d14-aae1-47b1-afc5-40e813dc496a" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ac0301d6-df05-428e-88be-5c0f4f7b654b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_ac0301d6-df05-428e-88be-5c0f4f7b654b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ac0301d6-df05-428e-88be-5c0f4f7b654b" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_ac0301d6-df05-428e-88be-5c0f4f7b654b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_b9ae0f7f-a98c-4716-92d4-de95f8a5a134" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_ac0301d6-df05-428e-88be-5c0f4f7b654b" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_b9ae0f7f-a98c-4716-92d4-de95f8a5a134" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BaqsimiMember_e05549e8-e856-4c5b-bbc1-bce0db2a7acb" xlink:href="lly-20240630.xsd#lly_BaqsimiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_b9ae0f7f-a98c-4716-92d4-de95f8a5a134" xlink:to="loc_lly_BaqsimiMember_e05549e8-e856-4c5b-bbc1-bce0db2a7acb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_a5a4d752-af6c-45c6-b553-fa5e6b7b18a9" xlink:href="lly-20240630.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_a5a4d752-af6c-45c6-b553-fa5e6b7b18a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_c33e8e48-a09e-4370-85b1-25c906aa95cd" xlink:href="lly-20240630.xsd#lly_CollaborativeArrangementRightsAndObligationsRightsObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsRightsObligations_c33e8e48-a09e-4370-85b1-25c906aa95cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_07f36263-dffb-40a2-9afc-462bd9b70fd1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_07f36263-dffb-40a2-9afc-462bd9b70fd1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_cccd8a2b-0025-4518-985e-eea876befaa2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_cccd8a2b-0025-4518-985e-eea876befaa2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived_1b5bcc57-b102-4a63-8b37-b970d5462ffe" xlink:href="lly-20240630.xsd#lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_lly_DisposalGroupIncludingDiscontinuedOperationMilestonePaymentsToBeReceived_1b5bcc57-b102-4a63-8b37-b970d5462ffe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_ee3ebd12-795b-4668-8301-a54ead6bf16c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a637cc3f-c2a0-4f7e-9f74-b8b2b4933467" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_ee3ebd12-795b-4668-8301-a54ead6bf16c" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_18268a90-000f-42ef-b322-b68023082ec3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:to="loc_us-gaap_DebtInstrumentAxis_18268a90-000f-42ef-b322-b68023082ec3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_18268a90-000f-42ef-b322-b68023082ec3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_18268a90-000f-42ef-b322-b68023082ec3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_18268a90-000f-42ef-b322-b68023082ec3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_18268a90-000f-42ef-b322-b68023082ec3" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A4.5NotesDue2027Member_679aeb96-151f-4f83-a582-7a57d51a0abb" xlink:href="lly-20240630.xsd#lly_A4.5NotesDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A4.5NotesDue2027Member_679aeb96-151f-4f83-a582-7a57d51a0abb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A4.5NotesDue2029Member_610433a2-bff9-4239-a1fc-45053984cfcc" xlink:href="lly-20240630.xsd#lly_A4.5NotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A4.5NotesDue2029Member_610433a2-bff9-4239-a1fc-45053984cfcc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A4.7NotesDue2034Member_bc7c2a99-32aa-428f-bcdf-263a503bacf5" xlink:href="lly-20240630.xsd#lly_A4.7NotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A4.7NotesDue2034Member_bc7c2a99-32aa-428f-bcdf-263a503bacf5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A5.0NotesDue2054Member_e3dc3a5f-cd53-4690-ae8c-584f8caa7e24" xlink:href="lly-20240630.xsd#lly_A5.0NotesDue2054Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A5.0NotesDue2054Member_e3dc3a5f-cd53-4690-ae8c-584f8caa7e24" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A5.1NotesDue2064Member_503c1a65-b90a-46b6-9428-b6873b0bad7d" xlink:href="lly-20240630.xsd#lly_A5.1NotesDue2064Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A5.1NotesDue2064Member_503c1a65-b90a-46b6-9428-b6873b0bad7d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SeniorNotesDue20272029203420542064Member_36e9d4fe-0eb1-441a-919c-e6eceffd1e5e" xlink:href="lly-20240630.xsd#lly_SeniorNotesDue20272029203420542064Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_SeniorNotesDue20272029203420542064Member_36e9d4fe-0eb1-441a-919c-e6eceffd1e5e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A50NotesDue2026Member_a2f16786-23bc-4707-8e33-f6fb3960f49f" xlink:href="lly-20240630.xsd#lly_A50NotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A50NotesDue2026Member_a2f16786-23bc-4707-8e33-f6fb3960f49f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A47NotesDue2033Member_dba693b8-3aab-429e-8678-f75d1173a2b3" xlink:href="lly-20240630.xsd#lly_A47NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A47NotesDue2033Member_dba693b8-3aab-429e-8678-f75d1173a2b3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A4875NotesDue2053Member_2779ca82-4741-405d-8ca5-c2e1fb654239" xlink:href="lly-20240630.xsd#lly_A4875NotesDue2053Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A4875NotesDue2053Member_2779ca82-4741-405d-8ca5-c2e1fb654239" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_A495NotesDue2063Member_8b418b9f-5040-4b59-878e-921d27227f1b" xlink:href="lly-20240630.xsd#lly_A495NotesDue2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_A495NotesDue2063Member_8b418b9f-5040-4b59-878e-921d27227f1b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SeniorNotesDue202620332053And2063Member_e8ec593d-e53e-4196-a071-27ed1f8f1ce9" xlink:href="lly-20240630.xsd#lly_SeniorNotesDue202620332053And2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1ef200d8-7f87-4e00-8dc2-e249ec08007b" xlink:to="loc_lly_SeniorNotesDue202620332053And2063Member_e8ec593d-e53e-4196-a071-27ed1f8f1ce9" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_4f417916-4004-43de-b362-cf060de6e521" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_4f417916-4004-43de-b362-cf060de6e521" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4f417916-4004-43de-b362-cf060de6e521_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_4f417916-4004-43de-b362-cf060de6e521" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4f417916-4004-43de-b362-cf060de6e521_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d8b5d2ef-0bb0-4bdf-8d1d-558862e79b9f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_4f417916-4004-43de-b362-cf060de6e521" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d8b5d2ef-0bb0-4bdf-8d1d-558862e79b9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_64f0a0c7-36fe-4ea8-97ff-72cb0959e6fa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_d8b5d2ef-0bb0-4bdf-8d1d-558862e79b9f" xlink:to="loc_us-gaap_SeniorNotesMember_64f0a0c7-36fe-4ea8-97ff-72cb0959e6fa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ForeignCurrencyDenominatedDebtMember_4cbf2532-a47e-49e4-864f-1584b6020209" xlink:href="lly-20240630.xsd#lly_ForeignCurrencyDenominatedDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_d8b5d2ef-0bb0-4bdf-8d1d-558862e79b9f" xlink:to="loc_lly_ForeignCurrencyDenominatedDebtMember_4cbf2532-a47e-49e4-864f-1584b6020209" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_bc6e2593-8a12-436e-bed5-277619127baa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_bc6e2593-8a12-436e-bed5-277619127baa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_bc6e2593-8a12-436e-bed5-277619127baa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bc6e2593-8a12-436e-bed5-277619127baa" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_bc6e2593-8a12-436e-bed5-277619127baa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bc6e2593-8a12-436e-bed5-277619127baa" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SwapU.S.DollarsToEuroMember_e55b056e-1ced-46ed-8be1-c7e415d17485" xlink:href="lly-20240630.xsd#lly_SwapU.S.DollarsToEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:to="loc_lly_SwapU.S.DollarsToEuroMember_e55b056e-1ced-46ed-8be1-c7e415d17485" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SwapSwissFrancsToU.S.DollarsMember_26a70a22-10c8-4fce-a049-4044c6586638" xlink:href="lly-20240630.xsd#lly_SwapSwissFrancsToU.S.DollarsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:to="loc_lly_SwapSwissFrancsToU.S.DollarsMember_26a70a22-10c8-4fce-a049-4044c6586638" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SellEuroMember_e077a118-9fae-4442-bbd3-dcebf49987a1" xlink:href="lly-20240630.xsd#lly_SellEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:to="loc_lly_SellEuroMember_e077a118-9fae-4442-bbd3-dcebf49987a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_SellChineseYuanMember_de11fef5-99da-49c3-980a-c550b7cafd34" xlink:href="lly-20240630.xsd#lly_SellChineseYuanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:to="loc_lly_SellChineseYuanMember_de11fef5-99da-49c3-980a-c550b7cafd34" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_8631f058-5bc0-487f-8c80-9c856ed15231" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d98a6dfd-a3c7-41ae-8cff-2ebf096817e5" xlink:to="loc_us-gaap_InterestRateSwapMember_8631f058-5bc0-487f-8c80-9c856ed15231" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_e7ce2760-7062-4f87-8639-775bd274681b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_a619c85b-6b5c-4ea9-a395-3bd7f8acb19d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_e7ce2760-7062-4f87-8639-775bd274681b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_aa287c3a-8688-443d-a35f-5044bb452644" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e7ce2760-7062-4f87-8639-775bd274681b" xlink:to="loc_us-gaap_CashFlowHedgingMember_aa287c3a-8688-443d-a35f-5044bb452644" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_5998d564-9ff4-432c-8842-4296b60f49b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_1342dda5-5677-435f-a8e3-7a6bd6c5191c" xlink:to="loc_us-gaap_HedgingDesignationAxis_5998d564-9ff4-432c-8842-4296b60f49b1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_5998d564-9ff4-432c-8842-4296b60f49b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_5998d564-9ff4-432c-8842-4296b60f49b1" xlink:to="loc_us-gaap_HedgingDesignationDomain_5998d564-9ff4-432c-8842-4296b60f49b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_db3f72e7-d5f6-4c3f-986c-e77632df5508" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_5998d564-9ff4-432c-8842-4296b60f49b1" xlink:to="loc_us-gaap_HedgingDesignationDomain_db3f72e7-d5f6-4c3f-986c-e77632df5508" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_adb9aaa7-3608-43f1-a0b3-2234ba538423" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_db3f72e7-d5f6-4c3f-986c-e77632df5508" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_adb9aaa7-3608-43f1-a0b3-2234ba538423" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_7d1ab5dd-1cde-4168-b0dc-c7e7025761f0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_7d1ab5dd-1cde-4168-b0dc-c7e7025761f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments_824b9c74-016d-4ec8-8ff8-31ade3c2c25e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommittments_824b9c74-016d-4ec8-8ff8-31ade3c2c25e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod_97b29cb3-80df-4b67-8833-d46ab844eb90" xlink:href="lly-20240630.xsd#lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_lly_FairValueInvestmentsEntitiesThatCalculateNetAssetValuePerShareUnfundedCommitmentsPaymentPeriod_97b29cb3-80df-4b67-8833-d46ab844eb90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_ProceedsFromSaleOfEquityAndAvailableForSaleSecurities_13629400-20e0-4306-9cfb-fc022066b825" xlink:href="lly-20240630.xsd#lly_ProceedsFromSaleOfEquityAndAvailableForSaleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_lly_ProceedsFromSaleOfEquityAndAvailableForSaleSecurities_13629400-20e0-4306-9cfb-fc022066b825" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_f0472366-4b74-4096-8935-1efd24c0b607" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_f0472366-4b74-4096-8935-1efd24c0b607" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_31eb6d00-7fb3-42b0-a0ba-ea6cc00047c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_31eb6d00-7fb3-42b0-a0ba-ea6cc00047c0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_8c4b8761-cd97-4ccc-89e2-3acaad34b315" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_8c4b8761-cd97-4ccc-89e2-3acaad34b315" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_dde4c5c3-e672-4202-8d65-28616fe4300c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_dde4c5c3-e672-4202-8d65-28616fe4300c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_6f19c325-ab4e-413a-a5e2-f909067de595" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_6f19c325-ab4e-413a-a5e2-f909067de595" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_6300dd48-9a68-4be6-a085-c1154edb3144" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_6300dd48-9a68-4be6-a085-c1154edb3144" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_329a8400-bb15-48c4-835e-0d2171c27a06" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_LongTermDebt_329a8400-bb15-48c4-835e-0d2171c27a06" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_112afe8f-a795-491c-99a5-7400827560f3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_112afe8f-a795-491c-99a5-7400827560f3" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_81b0c569-1c7f-4f0d-a5a7-a51e0eca9da9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_81b0c569-1c7f-4f0d-a5a7-a51e0eca9da9" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_faad4236-d642-4a8e-9874-d7cb341f7119" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_faad4236-d642-4a8e-9874-d7cb341f7119" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_62dd07cf-401a-4470-8a03-8bf0e539fc8d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_62dd07cf-401a-4470-8a03-8bf0e539fc8d" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_1eaff2e5-74d2-4376-8e3d-c27311a94d86" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_d78b88d9-f0e9-4629-a12f-0d051dd233c0" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_1eaff2e5-74d2-4376-8e3d-c27311a94d86" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofFairValueMeasurementDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsScheduleofFairValueMeasurementDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofFairValueMeasurementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_74ce2b69-6850-45f1-ad62-7470c6498c88" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_74ce2b69-6850-45f1-ad62-7470c6498c88" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_d60e482c-b2d3-4486-8a7b-760462236f6c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_74ce2b69-6850-45f1-ad62-7470c6498c88" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_d60e482c-b2d3-4486-8a7b-760462236f6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_d60e482c-b2d3-4486-8a7b-760462236f6c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_d60e482c-b2d3-4486-8a7b-760462236f6c" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_d60e482c-b2d3-4486-8a7b-760462236f6c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_d60e482c-b2d3-4486-8a7b-760462236f6c" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_16c7eedc-66e2-42c6-bbff-fe3ba3250a6d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_16c7eedc-66e2-42c6-bbff-fe3ba3250a6d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_c4afb8e7-439b-4527-b78c-f20f60714a13" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_c4afb8e7-439b-4527-b78c-f20f60714a13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_b9bff424-5772-4982-89d9-cc47cb3a293d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_b9bff424-5772-4982-89d9-cc47cb3a293d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_8aafd4e8-fcfe-4be9-ae66-bedbad137d70" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_d917e4d7-e55a-4300-b595-ae599e0d74ef" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_8aafd4e8-fcfe-4be9-ae66-bedbad137d70" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5a17cc05-072e-4992-8a8c-4a220e301a89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_74ce2b69-6850-45f1-ad62-7470c6498c88" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5a17cc05-072e-4992-8a8c-4a220e301a89" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5a17cc05-072e-4992-8a8c-4a220e301a89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5a17cc05-072e-4992-8a8c-4a220e301a89" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5a17cc05-072e-4992-8a8c-4a220e301a89_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8e82f484-eb3a-42f1-aed1-ae5858649725" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_5a17cc05-072e-4992-8a8c-4a220e301a89" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8e82f484-eb3a-42f1-aed1-ae5858649725" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_8b8376a8-ec73-40b6-988f-fc62845d3dd1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8e82f484-eb3a-42f1-aed1-ae5858649725" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_8b8376a8-ec73-40b6-988f-fc62845d3dd1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_fa382cc5-37dd-459c-aa38-18506a0d13b0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8e82f484-eb3a-42f1-aed1-ae5858649725" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_fa382cc5-37dd-459c-aa38-18506a0d13b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_54d3eef2-f874-4e24-914c-84bdb0e818e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8e82f484-eb3a-42f1-aed1-ae5858649725" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_54d3eef2-f874-4e24-914c-84bdb0e818e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_41b83b8a-81d8-4007-a7b1-9a7125a3499f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_74ce2b69-6850-45f1-ad62-7470c6498c88" xlink:to="loc_us-gaap_FinancialInstrumentAxis_41b83b8a-81d8-4007-a7b1-9a7125a3499f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_41b83b8a-81d8-4007-a7b1-9a7125a3499f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_41b83b8a-81d8-4007-a7b1-9a7125a3499f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_41b83b8a-81d8-4007-a7b1-9a7125a3499f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_41b83b8a-81d8-4007-a7b1-9a7125a3499f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_4af507d4-d035-4be8-874b-9df967f4ba12" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_4af507d4-d035-4be8-874b-9df967f4ba12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_d5cb1503-555a-4489-83df-fa1093944d43" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_d5cb1503-555a-4489-83df-fa1093944d43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_82256a03-b2ea-4d7c-97bb-d8d22b7626fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MortgageBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_82256a03-b2ea-4d7c-97bb-d8d22b7626fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_bf59b6e3-9c5c-4f11-9f03-b67d5fe9efb5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_bf59b6e3-9c5c-4f11-9f03-b67d5fe9efb5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_04879199-b359-4b34-82b7-b1bbc5bd27ec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_04879199-b359-4b34-82b7-b1bbc5bd27ec" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_OtherEquitySecuritiesMember_15036619-94ff-46bc-923f-2d77cb1d60b3" xlink:href="lly-20240630.xsd#lly_OtherEquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_lly_OtherEquitySecuritiesMember_15036619-94ff-46bc-923f-2d77cb1d60b3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_MarketableSecuritiesMember_5df71906-988a-429f-a7ea-bd70409df93b" xlink:href="lly-20240630.xsd#lly_MarketableSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f78a70c4-4122-42b4-b057-b633a6e33205" xlink:to="loc_lly_MarketableSecuritiesMember_5df71906-988a-429f-a7ea-bd70409df93b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_0e0043fb-e15d-4805-8bf0-5ff8c3136be5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_0e0043fb-e15d-4805-8bf0-5ff8c3136be5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_dd9e7fda-84fe-4e70-99b6-94e03f402b5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_dd9e7fda-84fe-4e70-99b6-94e03f402b5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_06326b71-b1da-489d-9c2c-ec18c25d65dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_06326b71-b1da-489d-9c2c-ec18c25d65dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_fa1475cc-1b91-4da8-b462-92b713cffd2b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_fa1475cc-1b91-4da8-b462-92b713cffd2b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_e6e43fd0-f73f-4163-8c03-df6cf3da8c27" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_e6e43fd0-f73f-4163-8c03-df6cf3da8c27" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_c42c9033-2609-4df9-b8ba-f70473e37d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_EquityMethodInvestments_c42c9033-2609-4df9-b8ba-f70473e37d5f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_99fe395b-ef27-494e-b03b-849f4402618f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9b6fe27a-0d3a-4340-940d-a42d4b3612b3" xlink:to="loc_us-gaap_LongTermInvestments_99fe395b-ef27-494e-b03b-849f4402618f" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofShorttermandLongtermClassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_497d2947-0d3f-4646-a022-9911a94537b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_7d33937a-d9a2-4126-89d1-b9b16b2f6a1b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_497d2947-0d3f-4646-a022-9911a94537b3" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_7d33937a-d9a2-4126-89d1-b9b16b2f6a1b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_7d33937a-d9a2-4126-89d1-b9b16b2f6a1b" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_e9298142-3368-4fd8-b13f-963f24050e68" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_3ca3c8d6-c86c-4f6f-aee6-ca7df6a9d750" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_e9298142-3368-4fd8-b13f-963f24050e68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3875726a-a912-4ad7-be98-6459bc5301e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_e9298142-3368-4fd8-b13f-963f24050e68" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3875726a-a912-4ad7-be98-6459bc5301e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_b2b04ef1-8dde-4346-b3a4-861b9f1fd300" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_e9298142-3368-4fd8-b13f-963f24050e68" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_b2b04ef1-8dde-4346-b3a4-861b9f1fd300" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_7667266f-23dc-447f-808e-a8944ee2b151" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_e9298142-3368-4fd8-b13f-963f24050e68" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_7667266f-23dc-447f-808e-a8944ee2b151" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_7d33937a-d9a2-4126-89d1-b9b16b2f6a1b" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_11666f16-c926-432b-ba1b-4db38b7bddaf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_3ea15bd3-6edb-4d9c-b8d0-70dc65a9cb4a" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_11666f16-c926-432b-ba1b-4db38b7bddaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_9e6e6199-1a4a-49f0-8b46-52bd2a064413" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_11666f16-c926-432b-ba1b-4db38b7bddaf" xlink:to="loc_us-gaap_CommercialPaperMember_9e6e6199-1a4a-49f0-8b46-52bd2a064413" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_28e2356a-08de-42f6-88a8-179431a11c5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_7d33937a-d9a2-4126-89d1-b9b16b2f6a1b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_28e2356a-08de-42f6-88a8-179431a11c5f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_28e2356a-08de-42f6-88a8-179431a11c5f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_28e2356a-08de-42f6-88a8-179431a11c5f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_28e2356a-08de-42f6-88a8-179431a11c5f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b35f4ac4-3dad-44bb-b0f6-deb281f2d2ed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_28e2356a-08de-42f6-88a8-179431a11c5f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b35f4ac4-3dad-44bb-b0f6-deb281f2d2ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_c971687b-60bc-453f-beb5-e43d62e0b5e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b35f4ac4-3dad-44bb-b0f6-deb281f2d2ed" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_c971687b-60bc-453f-beb5-e43d62e0b5e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_69e06035-8cc9-4eb9-b606-ffff6b5b709c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b35f4ac4-3dad-44bb-b0f6-deb281f2d2ed" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_69e06035-8cc9-4eb9-b606-ffff6b5b709c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_2cc9362c-bb59-4edb-b75b-2b583bc3a805" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b35f4ac4-3dad-44bb-b0f6-deb281f2d2ed" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_2cc9362c-bb59-4edb-b75b-2b583bc3a805" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaper_0d770814-4e33-4b40-ac87-1c902a26ae40" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommercialPaper"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_497d2947-0d3f-4646-a022-9911a94537b3" xlink:to="loc_us-gaap_CommercialPaper_0d770814-4e33-4b40-ac87-1c902a26ae40" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_e93dd0ce-d2ce-4e8d-9cf7-e159b3a666b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_497d2947-0d3f-4646-a022-9911a94537b3" xlink:to="loc_us-gaap_LongTermDebt_e93dd0ce-d2ce-4e8d-9cf7-e159b3a666b2" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofForeignCurrencyForwardCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsLineItems_4132b806-0ce7-4e9e-800b-f57daf4c35db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OffsettingAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTable_ed4fa20c-aeb1-41af-89d3-7e3178eb2afe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OffsettingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_4132b806-0ce7-4e9e-800b-f57daf4c35db" xlink:to="loc_us-gaap_OffsettingAssetsTable_ed4fa20c-aeb1-41af-89d3-7e3178eb2afe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_131f1080-8701-4af0-9bf3-730d4dfef4fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingAssetsTable_ed4fa20c-aeb1-41af-89d3-7e3178eb2afe" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_131f1080-8701-4af0-9bf3-730d4dfef4fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_131f1080-8701-4af0-9bf3-730d4dfef4fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_131f1080-8701-4af0-9bf3-730d4dfef4fc" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_131f1080-8701-4af0-9bf3-730d4dfef4fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_131f1080-8701-4af0-9bf3-730d4dfef4fc" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyEuroSellUsDollarMember_34954c02-869a-4984-99b7-ece02891b746" xlink:href="lly-20240630.xsd#lly_BuyEuroSellUsDollarMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:to="loc_lly_BuyEuroSellUsDollarMember_34954c02-869a-4984-99b7-ece02891b746" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyUsdSellEuroMember_e62f5143-1272-40a4-a084-0ad02e510517" xlink:href="lly-20240630.xsd#lly_BuyUsdSellEuroMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:to="loc_lly_BuyUsdSellEuroMember_e62f5143-1272-40a4-a084-0ad02e510517" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_eed82930-c20a-4b2b-9393-400671fe51c1" xlink:href="lly-20240630.xsd#lly_BuyUSdollarSellJapaneseYenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_eed82930-c20a-4b2b-9393-400671fe51c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_BuyGBPSellUSDMember_f8788fb6-482c-4f91-9f61-a4ed619591c1" xlink:href="lly-20240630.xsd#lly_BuyGBPSellUSDMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0833a1d3-b17f-4d58-bb54-15531d6ba944" xlink:to="loc_lly_BuyGBPSellUSDMember_f8788fb6-482c-4f91-9f61-a4ed619591c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_99828235-5402-4fed-8d92-08ae0abcb57c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_4132b806-0ce7-4e9e-800b-f57daf4c35db" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_99828235-5402-4fed-8d92-08ae0abcb57c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_88c30863-aadb-4193-8d84-d0ac43481b77" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_4132b806-0ce7-4e9e-800b-f57daf4c35db" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_88c30863-aadb-4193-8d84-d0ac43481b77" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofEffectofRiskManagementDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsScheduleofEffectofRiskManagementDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofEffectofRiskManagementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7fd1bfb-eb3e-4334-b0de-569dbac8a5f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7fd1bfb-eb3e-4334-b0de-569dbac8a5f9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_5d380ba0-c809-44b9-a0d7-a964be258752" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7fd1bfb-eb3e-4334-b0de-569dbac8a5f9" xlink:to="loc_us-gaap_HedgingDesignationAxis_5d380ba0-c809-44b9-a0d7-a964be258752" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_5d380ba0-c809-44b9-a0d7-a964be258752_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_5d380ba0-c809-44b9-a0d7-a964be258752" xlink:to="loc_us-gaap_HedgingDesignationDomain_5d380ba0-c809-44b9-a0d7-a964be258752_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_d323a051-be1a-4de2-aa72-f88c3e9218f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_5d380ba0-c809-44b9-a0d7-a964be258752" xlink:to="loc_us-gaap_HedgingDesignationDomain_d323a051-be1a-4de2-aa72-f88c3e9218f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e296cc5a-c775-425f-8777-2145e1290bea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_d323a051-be1a-4de2-aa72-f88c3e9218f9" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e296cc5a-c775-425f-8777-2145e1290bea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_c2f2fb7f-4107-42c1-a8dc-848b84c96b8e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_d323a051-be1a-4de2-aa72-f88c3e9218f9" xlink:to="loc_us-gaap_NondesignatedMember_c2f2fb7f-4107-42c1-a8dc-848b84c96b8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d7fd1bfb-eb3e-4334-b0de-569dbac8a5f9" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_71203bdb-bbbf-4bbe-97bb-d1f00ba7f633" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_HedgedFixedRateDebtMember_78b52aa4-44ed-4b99-8ad8-1d7ab94bfa8d" xlink:href="lly-20240630.xsd#lly_HedgedFixedRateDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:to="loc_lly_HedgedFixedRateDebtMember_78b52aa4-44ed-4b99-8ad8-1d7ab94bfa8d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_fbdab336-713a-4866-936c-0c5db55ef926" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:to="loc_us-gaap_InterestRateContractMember_fbdab336-713a-4866-936c-0c5db55ef926" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_d337b997-99c6-4346-aed7-3ae25ec8d87a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_d337b997-99c6-4346-aed7-3ae25ec8d87a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_36fd3445-8159-422d-82a1-a927e30c5172" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:to="loc_us-gaap_ForeignExchangeContractMember_36fd3445-8159-422d-82a1-a927e30c5172" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_d6122a67-f12b-4483-9a8f-173845edd86c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5256a456-d3ab-4d34-a92c-00dca57228e8" xlink:to="loc_us-gaap_InterestRateSwapMember_d6122a67-f12b-4483-9a8f-173845edd86c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_FairValueHedgeAbstract_4c79cf16-6651-40ef-acac-7bce49a1a2c8" xlink:href="lly-20240630.xsd#lly_FairValueHedgeAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_lly_FairValueHedgeAbstract_4c79cf16-6651-40ef-acac-7bce49a1a2c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_2a48c9a4-5ff4-4cba-98a2-4e2379c9f49a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_4c79cf16-6651-40ef-acac-7bce49a1a2c8" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_2a48c9a4-5ff4-4cba-98a2-4e2379c9f49a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_b7efe5a3-c92b-4073-a732-4d234cd94912" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_4c79cf16-6651-40ef-acac-7bce49a1a2c8" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_b7efe5a3-c92b-4073-a732-4d234cd94912" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_CashFlowHedgeAbstract_11a0c09b-da04-4a27-838d-21a57085a1e5" xlink:href="lly-20240630.xsd#lly_CashFlowHedgeAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_lly_CashFlowHedgeAbstract_11a0c09b-da04-4a27-838d-21a57085a1e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_36c29b3b-5f84-4ad2-893c-71dba213f8b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CashFlowHedgeAbstract_11a0c09b-da04-4a27-838d-21a57085a1e5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_36c29b3b-5f84-4ad2-893c-71dba213f8b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_b6ae8f27-2165-4012-ab79-3ed12efff160" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_b6ae8f27-2165-4012-ab79-3ed12efff160" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_DerivativeInstrumentsGainLossRecognized_5201429d-d5c0-4234-8303-289f779817cb" xlink:href="lly-20240630.xsd#lly_DerivativeInstrumentsGainLossRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_lly_DerivativeInstrumentsGainLossRecognized_5201429d-d5c0-4234-8303-289f779817cb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_6d47f9ad-3c97-4326-b39c-d07a79909e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_6d47f9ad-3c97-4326-b39c-d07a79909e5f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_86b27830-6a6a-41d0-8257-18e79143e403" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_828fc921-8c53-4f00-95d5-74144c105198" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_86b27830-6a6a-41d0-8257-18e79143e403" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleofRiskManagementInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7636de73-a26f-40c4-8443-38a1cd8e4f7c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7636de73-a26f-40c4-8443-38a1cd8e4f7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_7636de73-a26f-40c4-8443-38a1cd8e4f7c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7636de73-a26f-40c4-8443-38a1cd8e4f7c" xlink:to="loc_us-gaap_HedgingRelationshipDomain_7636de73-a26f-40c4-8443-38a1cd8e4f7c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_e4f17a47-39b3-4501-890c-1408c824fdc2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7636de73-a26f-40c4-8443-38a1cd8e4f7c" xlink:to="loc_us-gaap_HedgingRelationshipDomain_e4f17a47-39b3-4501-890c-1408c824fdc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_26637224-2b4e-4afe-9176-db799d911187" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e4f17a47-39b3-4501-890c-1408c824fdc2" xlink:to="loc_us-gaap_FairValueHedgingMember_26637224-2b4e-4afe-9176-db799d911187" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_f76b4f65-9cf6-4215-a7e5-b33980dca759" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e4f17a47-39b3-4501-890c-1408c824fdc2" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_f76b4f65-9cf6-4215-a7e5-b33980dca759" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_b74fd637-c5e8-4f93-96e8-63ff0afa9fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e4f17a47-39b3-4501-890c-1408c824fdc2" xlink:to="loc_us-gaap_CashFlowHedgingMember_b74fd637-c5e8-4f93-96e8-63ff0afa9fb2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_803126ef-e1fe-418a-a494-8048c0a249d7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_803126ef-e1fe-418a-a494-8048c0a249d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_803126ef-e1fe-418a-a494-8048c0a249d7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_803126ef-e1fe-418a-a494-8048c0a249d7" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_803126ef-e1fe-418a-a494-8048c0a249d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2fd15625-a056-4144-b550-70e0ed1c1267" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_803126ef-e1fe-418a-a494-8048c0a249d7" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2fd15625-a056-4144-b550-70e0ed1c1267" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_5f58ddd4-fe64-47d0-b263-0fde0c61a9fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2fd15625-a056-4144-b550-70e0ed1c1267" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_5f58ddd4-fe64-47d0-b263-0fde0c61a9fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_bd3b5432-6278-483c-b0d3-28a786a094ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2fd15625-a056-4144-b550-70e0ed1c1267" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_bd3b5432-6278-483c-b0d3-28a786a094ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_6ae78581-3b4c-46c3-a3b7-e49990226923" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2fd15625-a056-4144-b550-70e0ed1c1267" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_6ae78581-3b4c-46c3-a3b7-e49990226923" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_486579a9-a547-49cd-bc81-859be9383a36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_486579a9-a547-49cd-bc81-859be9383a36" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_486579a9-a547-49cd-bc81-859be9383a36_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_486579a9-a547-49cd-bc81-859be9383a36" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_486579a9-a547-49cd-bc81-859be9383a36_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_4d864789-acd5-4d4d-920a-74bacec1e286" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_486579a9-a547-49cd-bc81-859be9383a36" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_4d864789-acd5-4d4d-920a-74bacec1e286" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_1917175c-4806-4848-a56b-71977f5c7986" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4d864789-acd5-4d4d-920a-74bacec1e286" xlink:to="loc_us-gaap_InterestRateContractMember_1917175c-4806-4848-a56b-71977f5c7986" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_3ac26a4a-0fad-4c67-a0b8-7208b0c0d98f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4d864789-acd5-4d4d-920a-74bacec1e286" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_3ac26a4a-0fad-4c67-a0b8-7208b0c0d98f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_bb8848b1-c94d-4a28-931a-c0c270bd9aed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4d864789-acd5-4d4d-920a-74bacec1e286" xlink:to="loc_us-gaap_ForeignExchangeContractMember_bb8848b1-c94d-4a28-931a-c0c270bd9aed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_e848b16e-2b35-433e-89d1-7f9075f945de" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:to="loc_us-gaap_HedgingDesignationAxis_e848b16e-2b35-433e-89d1-7f9075f945de" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_e848b16e-2b35-433e-89d1-7f9075f945de_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_e848b16e-2b35-433e-89d1-7f9075f945de" xlink:to="loc_us-gaap_HedgingDesignationDomain_e848b16e-2b35-433e-89d1-7f9075f945de_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_3d2e1ce1-7f41-46c1-999c-defc12ac9e92" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_e848b16e-2b35-433e-89d1-7f9075f945de" xlink:to="loc_us-gaap_HedgingDesignationDomain_3d2e1ce1-7f41-46c1-999c-defc12ac9e92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_547ee7ab-4db5-4a03-bbfa-f801e0014197" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_3d2e1ce1-7f41-46c1-999c-defc12ac9e92" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_547ee7ab-4db5-4a03-bbfa-f801e0014197" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_7bcedc62-30b4-4390-946c-8ed2111183e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_3d2e1ce1-7f41-46c1-999c-defc12ac9e92" xlink:to="loc_us-gaap_NondesignatedMember_7bcedc62-30b4-4390-946c-8ed2111183e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0d6561a2-01cf-42ca-b608-17748e760695" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_b69399cf-d6eb-4b34-8c9f-ae58880924e4" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0d6561a2-01cf-42ca-b608-17748e760695" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0d6561a2-01cf-42ca-b608-17748e760695_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0d6561a2-01cf-42ca-b608-17748e760695" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0d6561a2-01cf-42ca-b608-17748e760695_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_30cc7ce5-ed5c-4e75-860c-9a54227e9ba5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_0d6561a2-01cf-42ca-b608-17748e760695" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_30cc7ce5-ed5c-4e75-860c-9a54227e9ba5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_c60faf74-a80c-43eb-b89d-f3ef41787131" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_30cc7ce5-ed5c-4e75-860c-9a54227e9ba5" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_c60faf74-a80c-43eb-b89d-f3ef41787131" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_33b3dead-1d88-4aa0-a443-299d44ef0022" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_30cc7ce5-ed5c-4e75-860c-9a54227e9ba5" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_33b3dead-1d88-4aa0-a443-299d44ef0022" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_5951ad2e-e99f-4a9e-9b53-d1d5e9093b90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_30cc7ce5-ed5c-4e75-860c-9a54227e9ba5" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_5951ad2e-e99f-4a9e-9b53-d1d5e9093b90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_91ed365d-d527-4df3-beef-4817f856f0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_91ed365d-d527-4df3-beef-4817f856f0e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityCurrentStatementOfFinancialPositionExtensibleEnumeration_b0e0635f-2dc6-437c-b7f5-37239bb570e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilityCurrentStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_DerivativeLiabilityCurrentStatementOfFinancialPositionExtensibleEnumeration_b0e0635f-2dc6-437c-b7f5-37239bb570e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_ea5a5319-aca4-4126-a09f-7d13d9f68b9f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_ea5a5319-aca4-4126-a09f-7d13d9f68b9f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_f6b5cb07-ea62-4d4f-9cc9-01eab4ca5951" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_f6b5cb07-ea62-4d4f-9cc9-01eab4ca5951" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_f58b2c0d-a83a-47ed-9146-e243c03fdf85" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_f58b2c0d-a83a-47ed-9146-e243c03fdf85" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_945db2d6-5314-4677-8cdf-4b7a51069dee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_945db2d6-5314-4677-8cdf-4b7a51069dee" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_9effe096-3f21-4117-9be0-0079598163f2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_a41e03c4-dae9-4662-9f78-21f8a4d94a69" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_9effe096-3f21-4117-9be0-0079598163f2" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsComponentsofNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_9bd0419c-ae08-47e6-8ae8-a496411dabe7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_9bd0419c-ae08-47e6-8ae8-a496411dabe7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_072c6bed-2ffe-42cf-af7c-958a3982630d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_9bd0419c-ae08-47e6-8ae8-a496411dabe7" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_072c6bed-2ffe-42cf-af7c-958a3982630d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_072c6bed-2ffe-42cf-af7c-958a3982630d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_072c6bed-2ffe-42cf-af7c-958a3982630d" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_072c6bed-2ffe-42cf-af7c-958a3982630d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_f5abe58e-0a6b-473a-80a1-980f417c93de" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_072c6bed-2ffe-42cf-af7c-958a3982630d" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_f5abe58e-0a6b-473a-80a1-980f417c93de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_c1849bc8-1542-4f54-b904-061c123d2554" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_f5abe58e-0a6b-473a-80a1-980f417c93de" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_c1849bc8-1542-4f54-b904-061c123d2554" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_a55c5675-38e4-4947-a8e1-35d13a9f1f83" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_f5abe58e-0a6b-473a-80a1-980f417c93de" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_a55c5675-38e4-4947-a8e1-35d13a9f1f83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_02227b34-6c24-4a69-a851-f56203d54d93" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_02227b34-6c24-4a69-a851-f56203d54d93" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_badee4d6-690c-4565-9edf-94f5410419f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_badee4d6-690c-4565-9edf-94f5410419f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_cb3b569f-1b14-4eb6-9db2-584e27e449b4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_cb3b569f-1b14-4eb6-9db2-584e27e449b4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_d9ade130-09fe-41cb-a4af-5ee5ae47fc09" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_d9ade130-09fe-41cb-a4af-5ee5ae47fc09" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_95be8c26-fa03-4444-aacc-71bf10de190d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_95be8c26-fa03-4444-aacc-71bf10de190d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_059fc8f1-7a66-4a2d-b18c-eb1bbe67180c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_d3378344-2eb2-4009-83d5-f9684b869453" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_059fc8f1-7a66-4a2d-b18c-eb1bbe67180c" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#ContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_705e842b-e73f-4210-a90c-e6019a6d6200" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_dbb3e229-b740-4c99-8814-4c718d488cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_705e842b-e73f-4210-a90c-e6019a6d6200" xlink:to="loc_us-gaap_LossContingenciesTable_dbb3e229-b740-4c99-8814-4c718d488cdf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_0c278767-7529-49e5-959a-16b2aa17184d" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_dbb3e229-b740-4c99-8814-4c718d488cdf" xlink:to="loc_srt_LitigationCaseAxis_0c278767-7529-49e5-959a-16b2aa17184d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0c278767-7529-49e5-959a-16b2aa17184d_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_0c278767-7529-49e5-959a-16b2aa17184d" xlink:to="loc_srt_LitigationCaseTypeDomain_0c278767-7529-49e5-959a-16b2aa17184d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_537b51fc-e6a8-47c5-8521-a9160f1a5044" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_0c278767-7529-49e5-959a-16b2aa17184d" xlink:to="loc_srt_LitigationCaseTypeDomain_537b51fc-e6a8-47c5-8521-a9160f1a5044" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmgalityPatentLitigationMember_65003685-1a58-4f87-9b62-b08359f951f7" xlink:href="lly-20240630.xsd#lly_EmgalityPatentLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_537b51fc-e6a8-47c5-8521-a9160f1a5044" xlink:to="loc_lly_EmgalityPatentLitigationMember_65003685-1a58-4f87-9b62-b08359f951f7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmployeeLitigationJuly2018RulingMember_453b42eb-5ad7-4c9a-8aaa-76e39e39c4bf" xlink:href="lly-20240630.xsd#lly_EmployeeLitigationJuly2018RulingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_537b51fc-e6a8-47c5-8521-a9160f1a5044" xlink:to="loc_lly_EmployeeLitigationJuly2018RulingMember_453b42eb-5ad7-4c9a-8aaa-76e39e39c4bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_EmployeeLitigationJuly2019RulingMember_62a744f5-4558-4830-825a-cdb503e4623f" xlink:href="lly-20240630.xsd#lly_EmployeeLitigationJuly2019RulingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_537b51fc-e6a8-47c5-8521-a9160f1a5044" xlink:to="loc_lly_EmployeeLitigationJuly2019RulingMember_62a744f5-4558-4830-825a-cdb503e4623f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_68cb7a0a-69e7-417b-8390-265ef68051e4" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_dbb3e229-b740-4c99-8814-4c718d488cdf" xlink:to="loc_srt_StatementGeographicalAxis_68cb7a0a-69e7-417b-8390-265ef68051e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_68cb7a0a-69e7-417b-8390-265ef68051e4_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_68cb7a0a-69e7-417b-8390-265ef68051e4" xlink:to="loc_srt_SegmentGeographicalDomain_68cb7a0a-69e7-417b-8390-265ef68051e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_ddd7abb4-b6f5-4198-8b57-929f06085e05" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_68cb7a0a-69e7-417b-8390-265ef68051e4" xlink:to="loc_srt_SegmentGeographicalDomain_ddd7abb4-b6f5-4198-8b57-929f06085e05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_BR_a3251034-2019-4f2a-97f2-0c23fb50a4c6" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_BR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_ddd7abb4-b6f5-4198-8b57-929f06085e05" xlink:to="loc_country_BR_a3251034-2019-4f2a-97f2-0c23fb50a4c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_LossContingencyNumberOfPatents_52f5686b-7b7a-467c-bc13-8ce999806c4c" xlink:href="lly-20240630.xsd#lly_LossContingencyNumberOfPatents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_705e842b-e73f-4210-a90c-e6019a6d6200" xlink:to="loc_lly_LossContingencyNumberOfPatents_52f5686b-7b7a-467c-bc13-8ce999806c4c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_1effff1d-8517-4049-9ac6-94739a652ca6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyDamagesAwardedValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_705e842b-e73f-4210-a90c-e6019a6d6200" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_1effff1d-8517-4049-9ac6-94739a652ca6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossAOCIDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#OtherComprehensiveIncomeLossAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_c87cb70a-596e-4af3-8f4e-61765d92dba8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_113da8ae-7303-46e4-a448-91e10f1c13b4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_c87cb70a-596e-4af3-8f4e-61765d92dba8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_113da8ae-7303-46e4-a448-91e10f1c13b4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_ac86c4df-c286-42dd-8197-8dc20d896702" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_113da8ae-7303-46e4-a448-91e10f1c13b4" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_ac86c4df-c286-42dd-8197-8dc20d896702" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ac86c4df-c286-42dd-8197-8dc20d896702_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_ac86c4df-c286-42dd-8197-8dc20d896702" xlink:to="loc_us-gaap_EquityComponentDomain_ac86c4df-c286-42dd-8197-8dc20d896702_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c961a952-fb2f-4b24-ac99-dc86772ef6ee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_ac86c4df-c286-42dd-8197-8dc20d896702" xlink:to="loc_us-gaap_EquityComponentDomain_c961a952-fb2f-4b24-ac99-dc86772ef6ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c961a952-fb2f-4b24-ac99-dc86772ef6ee" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_560ab026-c4ee-4c68-9c80-1f812d72ae8e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_560ab026-c4ee-4c68-9c80-1f812d72ae8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_27872a80-f2d8-4a52-ac99-0a805170911f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_27872a80-f2d8-4a52-ac99-0a805170911f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_d3827604-cd38-47ae-a10d-bad44e4d6da8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_d3827604-cd38-47ae-a10d-bad44e4d6da8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_7fdad811-2cc3-458b-94a2-3a1a9bb54307" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_bed411f5-2a10-4316-b4dd-6d87f1a49843" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_7fdad811-2cc3-458b-94a2-3a1a9bb54307" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_c87cb70a-596e-4af3-8f4e-61765d92dba8" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a4fb0d09-956e-4d05-a03e-9ba8a7c5c544" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a4fb0d09-956e-4d05-a03e-9ba8a7c5c544" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_3a9a3831-dfc6-43f3-899a-d62b3644ca0a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_3a9a3831-dfc6-43f3-899a-d62b3644ca0a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_b39df70d-17fc-45bc-8374-7d1b82332262" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_b39df70d-17fc-45bc-8374-7d1b82332262" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_4e462cb8-bdb4-41ff-9230-e5a3187ca491" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_63caab3e-a374-4c32-930e-3a4caf84d89a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_4e462cb8-bdb4-41ff-9230-e5a3187ca491" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5cd9c6c0-6f46-46b9-b81b-2ab78a69a9dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#OtherComprehensiveIncomeLossTaxEffectDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTaxEffectDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e0629c77-a23a-4491-83da-12ae9453586d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_96814a98-7789-4b0e-bc3d-029e2c7bde56" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e0629c77-a23a-4491-83da-12ae9453586d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_96814a98-7789-4b0e-bc3d-029e2c7bde56" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_83f9068f-d487-4a6c-a938-4427b33d1237" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_96814a98-7789-4b0e-bc3d-029e2c7bde56" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_83f9068f-d487-4a6c-a938-4427b33d1237" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_83f9068f-d487-4a6c-a938-4427b33d1237_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_83f9068f-d487-4a6c-a938-4427b33d1237" xlink:to="loc_us-gaap_EquityComponentDomain_83f9068f-d487-4a6c-a938-4427b33d1237_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_83f9068f-d487-4a6c-a938-4427b33d1237" xlink:to="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_5b7a10d2-e330-4fe5-aade-0d2671ec0cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_5b7a10d2-e330-4fe5-aade-0d2671ec0cdf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_3fd56d44-9e20-4883-8419-b7585bca50e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_3fd56d44-9e20-4883-8419-b7585bca50e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_d3554d6e-8cba-4e6c-b0e9-a739b3458669" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_d3554d6e-8cba-4e6c-b0e9-a739b3458669" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_b922f185-cfc4-4bff-a1e1-c811c83c3278" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6136287e-7fa2-46ee-890b-cd6b1dba15ed" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_b922f185-cfc4-4bff-a1e1-c811c83c3278" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_4aec9d21-4282-46ae-9a5c-0cc74919c313" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e0629c77-a23a-4491-83da-12ae9453586d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_4aec9d21-4282-46ae-9a5c-0cc74919c313" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="simple" xlink:href="lly-20240630.xsd#OtherComprehensiveIncomeLossReclassificationDetails"/>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossReclassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_91275794-48b1-48fc-9b70-96bdb8d2232e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_91275794-48b1-48fc-9b70-96bdb8d2232e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_bfcb14f9-b6d3-44da-8940-42ac5976affc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_91275794-48b1-48fc-9b70-96bdb8d2232e" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_bfcb14f9-b6d3-44da-8940-42ac5976affc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_bfcb14f9-b6d3-44da-8940-42ac5976affc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_bfcb14f9-b6d3-44da-8940-42ac5976affc" xlink:to="loc_us-gaap_EquityComponentDomain_bfcb14f9-b6d3-44da-8940-42ac5976affc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a35d4b72-7aee-4451-8841-867a9205b318" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_bfcb14f9-b6d3-44da-8940-42ac5976affc" xlink:to="loc_us-gaap_EquityComponentDomain_a35d4b72-7aee-4451-8841-867a9205b318" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6feda8e6-9d1d-4c1c-8274-9edb6e6fa82c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a35d4b72-7aee-4451-8841-867a9205b318" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6feda8e6-9d1d-4c1c-8274-9edb6e6fa82c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_3b4ee3b3-b1ab-4e18-b01a-d02aace51674" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6feda8e6-9d1d-4c1c-8274-9edb6e6fa82c" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_3b4ee3b3-b1ab-4e18-b01a-d02aace51674" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_60a2e7c9-9063-4f59-bbe8-1b5047cd1794" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_6feda8e6-9d1d-4c1c-8274-9edb6e6fa82c" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_60a2e7c9-9063-4f59-bbe8-1b5047cd1794" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_baa279ff-e6f1-4d51-994d-c57e07f8a497" xlink:href="lly-20240630.xsd#lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a35d4b72-7aee-4451-8841-867a9205b318" xlink:to="loc_lly_AccumulatedGainLossNetCashFlowHedgeAndForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_baa279ff-e6f1-4d51-994d-c57e07f8a497" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1a58e5c5-4488-415a-843c-4d994d4aef6c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_91275794-48b1-48fc-9b70-96bdb8d2232e" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1a58e5c5-4488-415a-843c-4d994d4aef6c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_1a58e5c5-4488-415a-843c-4d994d4aef6c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1a58e5c5-4488-415a-843c-4d994d4aef6c" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_1a58e5c5-4488-415a-843c-4d994d4aef6c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_a5ebb0fb-b8a1-4153-841f-d6f998e92f19" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_1a58e5c5-4488-415a-843c-4d994d4aef6c" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_a5ebb0fb-b8a1-4153-841f-d6f998e92f19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_755ecaf7-2e6c-40a7-a32d-6830268b8209" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_a5ebb0fb-b8a1-4153-841f-d6f998e92f19" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_755ecaf7-2e6c-40a7-a32d-6830268b8209" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_ed4bacad-7e22-42ce-84c5-73e31d7dac5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_ed4bacad-7e22-42ce-84c5-73e31d7dac5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_98ac46e4-da95-46cd-baf2-5a9c636c24ff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_98ac46e4-da95-46cd-baf2-5a9c636c24ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_5d19b923-f633-4b74-a14c-a45bffa4e96b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_5d19b923-f633-4b74-a14c-a45bffa4e96b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_cf2014a7-b4d9-441c-90e4-f61b3ee79077" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_b86fd903-cb20-4219-92bd-3a71085c2e8a" xlink:to="loc_us-gaap_ProfitLoss_cf2014a7-b4d9-441c-90e4-f61b3ee79077" xlink:type="arc" order="3"/>
  </link:definitionLink>
</link:linkbase>
